355,034 research outputs found
X-ray ptychography on low-dimensional hard-condensed matter materials
Tailoring structural, chemical, and electronic (dis-)order in heterogeneous media is one of the transformative opportunities to enable new functionalities and sciences in energy and quantum materials. This endeavor requires elemental, chemical, and magnetic sensitivities at the nano/atomic scale in two- and three-dimensional space. Soft X-ray radiation and hard X-ray radiation provided by synchrotron facilities have emerged as standard characterization probes owing to their inherent element-specificity and high intensity. One of the most promising methods in view of sensitivity and spatial resolution is coherent diffraction imaging, namely, X-ray ptychography, which is envisioned to take on the dominance of electron imaging techniques offering with atomic resolution in the age of diffraction limited light sources. In this review, we discuss the current research examples of far-field diffraction-based X-ray ptychography on two-dimensional and three-dimensional semiconductors, ferroelectrics, and ferromagnets and their blooming future as a mainstream tool for materials sciences
Pharmacokinetic Analysis of Gd-DTPA Enhancement in dynamic three-dimensional MRI of breast lesions
The purpose of this study was to demonstrate that dynamic MRI covering both breasts can provide sensitivity for tumor detection as well as specificity and sensitivity for differentiation of tumor malignancy. Three-dimensional gradient echo scans were used covering both breasts. Before Gd-DTPA bolus injection, two scans were obtained with different flip angles, and after injection, a dynamic series followed. Thirty-two patients were scanned according to this protocol. From these scans, in addition to enhancement, the value of T1 before injection was obtained. This was used to estimate the concentration of Gd-DTPA as well as the pharmacokinetic parameters governing its time course. Signal enhancement in three-dimensional dynamic scanning was shown to be a sensitive basis for detection of tumors. In our series, all but two mam-mographically suspicious lesions did enhance, and in three cases, additional enhancing lesions were found, two of which were in the contralateral breast. The parameter most suited for classification of breast lesions into benign or malignant was shown to be the pharmacokinetically defined permeability k31, which, for that test, gave a sensitivity of 92% and a specificity of 70%. Our three-dimensional dynamic MRI data are sensitive for detection of mammographically occult breast tumors and specific for classification of these as benign or malignant
New evidence of visual space anisotropy with autostereograms
Postprint (published version
Sensitivity analysis of oscillator models in the space of phase-response curves: Oscillators as open systems
Oscillator models are central to the study of system properties such as
entrainment or synchronization. Due to their nonlinear nature, few
system-theoretic tools exist to analyze those models. The paper develops a
sensitivity analysis for phase-response curves, a fundamental one-dimensional
phase reduction of oscillator models. The proposed theoretical and numerical
analysis tools are illustrated on several system-theoretic questions and models
arising in the biology of cellular rhythms
Hyperspectral colon tissue cell classification
A novel algorithm to discriminate between normal and malignant tissue cells of the human colon is presented. The microscopic level images of human colon tissue cells were acquired using hyperspectral imaging technology at contiguous wavelength intervals of visible light. While hyperspectral imagery data provides a wealth of information, its large size normally means high computational processing complexity. Several methods exist to avoid the so-called curse of dimensionality and hence reduce the computational complexity. In this study, we experimented with Principal Component Analysis (PCA) and two modifications of Independent Component Analysis (ICA). In the first stage of the algorithm, the extracted components are used to separate four constituent parts of the colon tissue: nuclei, cytoplasm, lamina propria, and lumen. The segmentation is performed in an unsupervised fashion using the nearest centroid clustering algorithm. The segmented image is further used, in the second stage of the classification algorithm, to exploit the spatial relationship between the labeled constituent parts. Experimental results using supervised Support Vector Machines (SVM) classification based on multiscale morphological features reveal the discrimination between normal and malignant tissue cells with a reasonable degree of accuracy
Sensitivity analysis of circadian entrainment in the space of phase response curves
Sensitivity analysis is a classical and fundamental tool to evaluate the role
of a given parameter in a given system characteristic. Because the phase
response curve is a fundamental input--output characteristic of oscillators, we
developed a sensitivity analysis for oscillator models in the space of phase
response curves. The proposed tool can be applied to high-dimensional
oscillator models without facing the curse of dimensionality obstacle
associated with numerical exploration of the parameter space. Application of
this tool to a state-of-the-art model of circadian rhythms suggests that it can
be useful and instrumental to biological investigations.Comment: 22 pages, 8 figures. Correction of a mistake in Definition 2.1. arXiv
admin note: text overlap with arXiv:1206.414
Neural Dynamics of Motion Processing and Speed Discrimination
A neural network model of visual motion perception and speed discrimination is presented. The model shows how a distributed population code of speed tuning, that realizes a size-speed correlation, can be derived from the simplest mechanisms whereby activations of multiple spatially short-range filters of different size are transformed into speed-tuned cell responses. These mechanisms use transient cell responses to moving stimuli, output thresholds that covary with filter size, and competition. These mechanisms are proposed to occur in the Vl→7 MT cortical processing stream. The model reproduces empirically derived speed discrimination curves and simulates data showing how visual speed perception and discrimination can be affected by stimulus contrast, duration, dot density and spatial frequency. Model motion mechanisms are analogous to mechanisms that have been used to model 3-D form and figure-ground perception. The model forms the front end of a larger motion processing system that has been used to simulate how global motion capture occurs, and how spatial attention is drawn to moving forms. It provides a computational foundation for an emerging neural theory of 3-D form and motion perception.Office of Naval Research (N00014-92-J-4015, N00014-91-J-4100, N00014-95-1-0657, N00014-95-1-0409, N00014-94-1-0597, N00014-95-1-0409); Air Force Office of Scientific Research (F49620-92-J-0499); National Science Foundation (IRI-90-00530
High-Dimensional Stochastic Design Optimization by Adaptive-Sparse Polynomial Dimensional Decomposition
This paper presents a novel adaptive-sparse polynomial dimensional
decomposition (PDD) method for stochastic design optimization of complex
systems. The method entails an adaptive-sparse PDD approximation of a
high-dimensional stochastic response for statistical moment and reliability
analyses; a novel integration of the adaptive-sparse PDD approximation and
score functions for estimating the first-order design sensitivities of the
statistical moments and failure probability; and standard gradient-based
optimization algorithms. New analytical formulae are presented for the design
sensitivities that are simultaneously determined along with the moments or the
failure probability. Numerical results stemming from mathematical functions
indicate that the new method provides more computationally efficient design
solutions than the existing methods. Finally, stochastic shape optimization of
a jet engine bracket with 79 variables was performed, demonstrating the power
of the new method to tackle practical engineering problems.Comment: 18 pages, 2 figures, to appear in Sparse Grids and
Applications--Stuttgart 2014, Lecture Notes in Computational Science and
Engineering 109, edited by J. Garcke and D. Pfl\"{u}ger, Springer
International Publishing, 201
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