The 1990 Johnson Space Center bibliography of scientific and technical papers

Abstracts are presented of scientific and technical papers written and/or presented by L. B. Johnson Space Center (JSC) authors, including civil servants, contractors, and grantees, during the calendar year of 1990. Citations include conference and symposium presentations, papers published in proceedings or other collective works, seminars, and workshop results, NASA formal report series (including contractually required final reports), and articles published in professional journals

"Inventories of Limbo": Post-Minimal Aesthetics in Cinema From the Readymade to Institutional Critique

This dissertation charts the philosophical premises of post-minimalism in the practices of experimental filmmakers and video artists, exploring specific reorientations of cinematic works since the late 1960s. Post-minimalism refers to a myriad of aesthetic transformations initiated by the conceptual art movement, interrogating the ontology of art from a perspective outside its historical bonds to medium, style, and Kantian aesthetic judgment. I examine three strategies in the progression of post-minimal aesthetic practice: the readymade, institutional critique, and seriality. A central goal of this research is to remap entrenched language and ideas in the spheres of the arts and cinema to point to a profound reciprocity between cinematic technology and post-minimal aesthetic intelligence, perception, and judgment. This research moves away from the problems raised by artificially constructed movements and prescriptive categories which inevitably produce important sites of exception, and look instead to the aesthetic engines of post-minimal artmaking offering opportunities for constant renewal, evolution, and refinement. I follow these aesthetic engines like a knights tour in chess, jumping through history, appearing in unexpected places and at unexpected times to draw continuities in the approach to the heretical breaks from modernism found in post-minimal aesthetic intelligence. I will primarily focus on four objects: William E. Jones Tearoom, Robert Smithsons Underground Cinema, Lis Rhodes collaborative intervention into the Film as Film exhibition, and Christian Marclays The Clock. Examining the use of Marcel Duchamps concept of the readymade, and its profound assault on both medium specificity and authorship, I illustrate radical new ethical imperatives in the presentation of found footage filmmaking. My two core chapters grapple with ontological and locative explorations of cinematic architectures and sites. The two projects discussed engage with institutional critique, a philosophical model of artmaking which directly engages the sites, economic infrastructures, administrative imperatives, and power dynamics of the cinema, museum, and gallery. Finally, I examine a case study in contemporary post-minimal practice through Christian Marclays 24-hour installation The Clock, and will explore its relationship to archival projects engaging in the collection, ordering, and hermeneutic approach to 20th century media. I will explore this installation as symptomatic of both a technologically determined grammar of collection for the now immense digital archive, and an archeological inclination for artists to thematize film history

Space Station Human Factors Research Review. Volume 3: Space Station Habitability and Function: Architectural Research

Articles are presented on a space station architectural elements model study, space station group activities habitability module study, full-scale architectural simulation techniques for space stations, and social factors in space station interiors

Telepresence: Joan Jonas and the Emergence of Performance and Video Art in the 1970s

This dissertation is a study of the early career of the American artist Joan Jonas that spans the years 1970-1984. At the turn of the 1970s, Jonas was one of the first artists to pick up a video camera. Exploring “live” video’s unique capacity to mediate the present moment, Jonas actively integrated the technology into her live pieces, which are some of the earliest examples of what was then first called “performance art.” Performance art has often been aligned with presence. In contrast, I argue that what at stake in the proliferation of live artworks by Jonas and others that merged performance and video was not a reserve of unmediated experience, but a presence that was newly technologized: telepresence. As Jonas investigated the novel ability to perform at a distance enabled by electronic media, her work led somewhere surprising: to telegraphy, telepathy, and the earliest telephones—“tele”-technologies that appear long obsolete (or completely fantastical). Evoking optical telegraphs, spirit mediums, speaking trumpets, and science fictional prostheses, Jonas’s early oeuvre reactivates the historical contexts and unrealized potentials surrounding these dead media. In so doing, she illuminates enduring formations of the body, subjectivity, and teletechnology underlying not only the twinned emergence of performance and video art in the 1970s, but also telepresence as a seemingly very contemporary (and increasingly pervasive) category of experience

Aerospace medicine and biology: A cumulative index to a continuing bibliography (supplement 345)

This publication is a cumulative index to the abstracts contained in Supplements 333 through 344 of Aerospace Medicine and Biology: A Continuing Bibliography. Seven indexes are included -- subject, personal author, corporate source, foreign technology, contract number, report number, and accession number

LONGITUDINAL CLONAL LINEAGE DYNAMICS AND FUNCTIONAL CHARACTERIZATION OF PANCREATIC CANCER CHEMO-RESISTANCE AND METASTASIZATION

In recent years, technological advancements, such as next-generation sequencing and single-cell interrogation techniques, have enriched our understanding in tumor heterogeneity. By dissecting tumors and characterizing clonal lineages, we are better understanding the intricacies of tumor evolution. Tumors are represented by the presence of and dynamic interactions amongst clonal lineages. Each lineage and each cell contributes to tumor dynamics through intrinsic and extrinsic mechanisms, and the variable responses of clones to perturbations in the environment, especially therapeutics, underlie disease progression and relapse. Thus, there exists a pressing need to understand the molecular mechanisms that determine the functional heterogeneity of tumor sub-clones to improve clinical outcomes. Clonal replica tumors (CRTs) is an in vivo platform created specifically to enable robust tracing and functional study of clones within a tumor. The establishment of CRTs is built upon our current concept of tumor heterogeneity, intrinsic cancer cell hierarchy and clonal self-renewal properties. The model allows researchers to create large cohorts of tumors in different animals that are identical in their clonal lineage composition (clonal correlation amongst tumors \u3e0.99). CRTs allow simultaneously tracking of tens of thousands of clonal lineages in different animals to provide a high level of resolution and biological reproducibility. CRTs are comprised of barcoded cells that can be identified and quantified. A critical feature is that we have developed a systematic method to isolate and expand essentially any of the clonal lineages present within a CRT in their naïve state; that is, we can characterize each sub-clonal lineage at the molecular and functional levels and correlate these findings with the behavior of the same lineage in vivo and in response to drugs. Here, based on the CRT model and its concept, we studied differential chemo-resistance among clones, where we identified pre-existing upregulation in DNA repair as a mechanism for chemo-resistance. Furthermore, through stringent statistical testing, we demonstrated orthotopic CRTs to be a powerful and robust model to quantitatively track clonal evolution. Specifically, we longitudinally tracked clones in models of pancreatic ductal adenocarcinoma (PDAC) from primary tumor expansion through metastasization, where we captured unexpected clonal dynamics and “alternating clonal dominance” naturally occurring in unperturbed tumors. Moreover, by characterizing pro- and none-metastasizing clones, we were able to identified key clonal intrinsic factors that determined the nature of tumor metastases. Finally, I will discuss distinct clonal evolution patterns that emerged under different environmental pressures, leading to the hypothesis of “tumor clonal fingerprint”, where the characteristic of a tumor could be defined by actively maintained ratio of different tumor lineages, which could provide measurable insights to how we approach treatments

Aerospace medicine and biology: A continuing bibliography with indexes (supplement 385)

This bibliography lists 536 reports, articles and other documents introduced into the NASA Scientific and Technical Information System Database. Subject coverage includes: aerospace medicine and physiology, life support systems and man/system technology, protective clothing, exobiology and extraterrestrial life, planetary biology, and flight crew behavior and performance