3,049 research outputs found
Chi-square-based scoring function for categorization of MEDLINE citations
Objectives: Text categorization has been used in biomedical informatics for
identifying documents containing relevant topics of interest. We developed a
simple method that uses a chi-square-based scoring function to determine the
likelihood of MEDLINE citations containing genetic relevant topic. Methods: Our
procedure requires construction of a genetic and a nongenetic domain document
corpus. We used MeSH descriptors assigned to MEDLINE citations for this
categorization task. We compared frequencies of MeSH descriptors between two
corpora applying chi-square test. A MeSH descriptor was considered to be a
positive indicator if its relative observed frequency in the genetic domain
corpus was greater than its relative observed frequency in the nongenetic
domain corpus. The output of the proposed method is a list of scores for all
the citations, with the highest score given to those citations containing MeSH
descriptors typical for the genetic domain. Results: Validation was done on a
set of 734 manually annotated MEDLINE citations. It achieved predictive
accuracy of 0.87 with 0.69 recall and 0.64 precision. We evaluated the method
by comparing it to three machine learning algorithms (support vector machines,
decision trees, na\"ive Bayes). Although the differences were not statistically
significantly different, results showed that our chi-square scoring performs as
good as compared machine learning algorithms. Conclusions: We suggest that the
chi-square scoring is an effective solution to help categorize MEDLINE
citations. The algorithm is implemented in the BITOLA literature-based
discovery support system as a preprocessor for gene symbol disambiguation
process.Comment: 34 pages, 2 figure
Improving average ranking precision in user searches for biomedical research datasets
Availability of research datasets is keystone for health and life science
study reproducibility and scientific progress. Due to the heterogeneity and
complexity of these data, a main challenge to be overcome by research data
management systems is to provide users with the best answers for their search
queries. In the context of the 2016 bioCADDIE Dataset Retrieval Challenge, we
investigate a novel ranking pipeline to improve the search of datasets used in
biomedical experiments. Our system comprises a query expansion model based on
word embeddings, a similarity measure algorithm that takes into consideration
the relevance of the query terms, and a dataset categorisation method that
boosts the rank of datasets matching query constraints. The system was
evaluated using a corpus with 800k datasets and 21 annotated user queries. Our
system provides competitive results when compared to the other challenge
participants. In the official run, it achieved the highest infAP among the
participants, being +22.3% higher than the median infAP of the participant's
best submissions. Overall, it is ranked at top 2 if an aggregated metric using
the best official measures per participant is considered. The query expansion
method showed positive impact on the system's performance increasing our
baseline up to +5.0% and +3.4% for the infAP and infNDCG metrics, respectively.
Our similarity measure algorithm seems to be robust, in particular compared to
Divergence From Randomness framework, having smaller performance variations
under different training conditions. Finally, the result categorization did not
have significant impact on the system's performance. We believe that our
solution could be used to enhance biomedical dataset management systems. In
particular, the use of data driven query expansion methods could be an
alternative to the complexity of biomedical terminologies
Temporal characteristics of the influence of punishment on perceptual decision making in the human brain
Perceptual decision making is the process by which information from sensory systems is combined and used to influence our behavior. In addition to the sensory input, this process can be affected by other factors, such as reward and punishment for correct and incorrect responses. To investigate the temporal dynamics of how monetary punishment influences perceptual decision making in humans, we collected electroencephalography (EEG) data during a perceptual categorization task whereby the punishment level for incorrect responses was parametrically manipulated across blocks of trials. Behaviorally, we observed improved accuracy for high relative to low punishment levels. Using multivariate linear discriminant analysis of the EEG, we identified multiple punishment-induced discriminating components with spatially distinct scalp topographies. Compared with components related to sensory evidence, components discriminating punishment levels appeared later in the trial, suggesting that punishment affects primarily late postsensory, decision-related processing. Crucially, the amplitude of these punishment components across participants was predictive of the size of the behavioral improvements induced by punishment. Finally, trial-by-trial changes in prestimulus oscillatory activity in the alpha and gamma bands were good predictors of the amplitude of these components. We discuss these findings in the context of increased motivation/attention, resulting from increases in punishment, which in turn yields improved decision-related processing
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