1,046 research outputs found
Manifold Learning in MR spectroscopy using nonlinear dimensionality reduction and unsupervised clustering
Purpose To investigate whether nonlinear dimensionality reduction improves unsupervised classification of 1H MRS brain tumor data compared with a linear method. Methods In vivo single-voxel 1H magnetic resonance spectroscopy (55 patients) and 1H magnetic resonance spectroscopy imaging (MRSI) (29 patients) data were acquired from histopathologically diagnosed gliomas. Data reduction using Laplacian eigenmaps (LE) or independent component analysis (ICA) was followed by k-means clustering or agglomerative hierarchical clustering (AHC) for unsupervised learning to assess tumor grade and for tissue type segmentation of MRSI data. Results An accuracy of 93% in classification of glioma grade II and grade IV, with 100% accuracy in distinguishing tumor and normal spectra, was obtained by LE with unsupervised clustering, but not with the combination of k-means and ICA. With 1H MRSI data, LE provided a more linear distribution of data for cluster analysis and better cluster stability than ICA. LE combined with k-means or AHC provided 91% accuracy for classifying tumor grade and 100% accuracy for identifying normal tissue voxels. Color-coded visualization of normal brain, tumor core, and infiltration regions was achieved with LE combined with AHC. Conclusion Purpose To investigate whether nonlinear dimensionality reduction improves unsupervised classification of 1H MRS brain tumor data compared with a linear method. Methods In vivo single-voxel 1H magnetic resonance spectroscopy (55 patients) and 1H magnetic resonance spectroscopy imaging (MRSI) (29 patients) data were acquired from histopathologically diagnosed gliomas. Data reduction using Laplacian eigenmaps (LE) or independent component analysis (ICA) was followed by k-means clustering or agglomerative hierarchical clustering (AHC) for unsupervised learning to assess tumor grade and for tissue type segmentation of MRSI data. Results An accuracy of 93% in classification of glioma grade II and grade IV, with 100% accuracy in distinguishing tumor and normal spectra, was obtained by LE with unsupervised clustering, but not with the combination of k-means and ICA. With 1H MRSI data, LE provided a more linear distribution of data for cluster analysis and better cluster stability than ICA. LE combined with k-means or AHC provided 91% accuracy for classifying tumor grade and 100% accuracy for identifying normal tissue voxels. Color-coded visualization of normal brain, tumor core, and infiltration regions was achieved with LE combined with AHC. Conclusion The LE method is promising for unsupervised clustering to separate brain and tumor tissue with automated color-coding for visualization of 1H MRSI data after cluster analysis
From neural PCA to deep unsupervised learning
A network supporting deep unsupervised learning is presented. The network is
an autoencoder with lateral shortcut connections from the encoder to decoder at
each level of the hierarchy. The lateral shortcut connections allow the higher
levels of the hierarchy to focus on abstract invariant features. While standard
autoencoders are analogous to latent variable models with a single layer of
stochastic variables, the proposed network is analogous to hierarchical latent
variables models. Learning combines denoising autoencoder and denoising sources
separation frameworks. Each layer of the network contributes to the cost
function a term which measures the distance of the representations produced by
the encoder and the decoder. Since training signals originate from all levels
of the network, all layers can learn efficiently even in deep networks. The
speedup offered by cost terms from higher levels of the hierarchy and the
ability to learn invariant features are demonstrated in experiments.Comment: A revised version of an article that has been accepted for
publication in Advances in Independent Component Analysis and Learning
Machines (2015), edited by Ella Bingham, Samuel Kaski, Jorma Laaksonen and
Jouko Lampine
Hyperspectral Unmixing Overview: Geometrical, Statistical, and Sparse Regression-Based Approaches
Imaging spectrometers measure electromagnetic energy scattered in their
instantaneous field view in hundreds or thousands of spectral channels with
higher spectral resolution than multispectral cameras. Imaging spectrometers
are therefore often referred to as hyperspectral cameras (HSCs). Higher
spectral resolution enables material identification via spectroscopic analysis,
which facilitates countless applications that require identifying materials in
scenarios unsuitable for classical spectroscopic analysis. Due to low spatial
resolution of HSCs, microscopic material mixing, and multiple scattering,
spectra measured by HSCs are mixtures of spectra of materials in a scene. Thus,
accurate estimation requires unmixing. Pixels are assumed to be mixtures of a
few materials, called endmembers. Unmixing involves estimating all or some of:
the number of endmembers, their spectral signatures, and their abundances at
each pixel. Unmixing is a challenging, ill-posed inverse problem because of
model inaccuracies, observation noise, environmental conditions, endmember
variability, and data set size. Researchers have devised and investigated many
models searching for robust, stable, tractable, and accurate unmixing
algorithms. This paper presents an overview of unmixing methods from the time
of Keshava and Mustard's unmixing tutorial [1] to the present. Mixing models
are first discussed. Signal-subspace, geometrical, statistical, sparsity-based,
and spatial-contextual unmixing algorithms are described. Mathematical problems
and potential solutions are described. Algorithm characteristics are
illustrated experimentally.Comment: This work has been accepted for publication in IEEE Journal of
Selected Topics in Applied Earth Observations and Remote Sensin
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