DeepCare: A Deep Dynamic Memory Model for Predictive Medicine

Personalized predictive medicine necessitates the modeling of patient illness and care processes, which inherently have long-term temporal dependencies. Healthcare observations, recorded in electronic medical records, are episodic and irregular in time. We introduce DeepCare, an end-to-end deep dynamic neural network that reads medical records, stores previous illness history, infers current illness states and predicts future medical outcomes. At the data level, DeepCare represents care episodes as vectors in space, models patient health state trajectories through explicit memory of historical records. Built on Long Short-Term Memory (LSTM), DeepCare introduces time parameterizations to handle irregular timed events by moderating the forgetting and consolidation of memory cells. DeepCare also incorporates medical interventions that change the course of illness and shape future medical risk. Moving up to the health state level, historical and present health states are then aggregated through multiscale temporal pooling, before passing through a neural network that estimates future outcomes. We demonstrate the efficacy of DeepCare for disease progression modeling, intervention recommendation, and future risk prediction. On two important cohorts with heavy social and economic burden -- diabetes and mental health -- the results show improved modeling and risk prediction accuracy.Comment: Accepted at JBI under the new name: "Predicting healthcare trajectories from medical records: A deep learning approach

Adaptive visual sampling

PhDVarious visual tasks may be analysed in the context of sampling from the visual field. In visual psychophysics, human visual sampling strategies have often been shown at a high-level to be driven by various information and resource related factors such as the limited capacity of the human cognitive system, the quality of information gathered, its relevance in context and the associated efficiency of recovering it. At a lower-level, we interpret many computer vision tasks to be rooted in similar notions of contextually-relevant, dynamic sampling strategies which are geared towards the filtering of pixel samples to perform reliable object association. In the context of object tracking, the reliability of such endeavours is fundamentally rooted in the continuing relevance of object models used for such filtering, a requirement complicated by realworld conditions such as dynamic lighting that inconveniently and frequently cause their rapid obsolescence. In the context of recognition, performance can be hindered by the lack of learned context-dependent strategies that satisfactorily filter out samples that are irrelevant or blunt the potency of models used for discrimination. In this thesis we interpret the problems of visual tracking and recognition in terms of dynamic spatial and featural sampling strategies and, in this vein, present three frameworks that build on previous methods to provide a more flexible and effective approach. Firstly, we propose an adaptive spatial sampling strategy framework to maintain statistical object models for real-time robust tracking under changing lighting conditions. We employ colour features in experiments to demonstrate its effectiveness. The framework consists of five parts: (a) Gaussian mixture models for semi-parametric modelling of the colour distributions of multicolour objects; (b) a constructive algorithm that uses cross-validation for automatically determining the number of components for a Gaussian mixture given a sample set of object colours; (c) a sampling strategy for performing fast tracking using colour models; (d) a Bayesian formulation enabling models of object and the environment to be employed together in filtering samples by discrimination; and (e) a selectively-adaptive mechanism to enable colour models to cope with changing conditions and permit more robust tracking. Secondly, we extend the concept to an adaptive spatial and featural sampling strategy to deal with very difficult conditions such as small target objects in cluttered environments undergoing severe lighting fluctuations and extreme occlusions. This builds on previous work on dynamic feature selection during tracking by reducing redundancy in features selected at each stage as well as more naturally balancing short-term and long-term evidence, the latter to facilitate model rigidity under sharp, temporary changes such as occlusion whilst permitting model flexibility under slower, long-term changes such as varying lighting conditions. This framework consists of two parts: (a) Attribute-based Feature Ranking (AFR) which combines two attribute measures; discriminability and independence to other features; and (b) Multiple Selectively-adaptive Feature Models (MSFM) which involves maintaining a dynamic feature reference of target object appearance. We call this framework Adaptive Multi-feature Association (AMA). Finally, we present an adaptive spatial and featural sampling strategy that extends established Local Binary Pattern (LBP) methods and overcomes many severe limitations of the traditional approach such as limited spatial support, restricted sample sets and ad hoc joint and disjoint statistical distributions that may fail to capture important structure. Our framework enables more compact, descriptive LBP type models to be constructed which may be employed in conjunction with many existing LBP techniques to improve their performance without modification. The framework consists of two parts: (a) a new LBP-type model known as Multiscale Selected Local Binary Features (MSLBF); and (b) a novel binary feature selection algorithm called Binary Histogram Intersection Minimisation (BHIM) which is shown to be more powerful than established methods used for binary feature selection such as Conditional Mutual Information Maximisation (CMIM) and AdaBoost

Child's play: activity recognition for monitoring children's developmental progress with augmented toys

The way in which infants play with objects can be indicative of their developmental progress and may serve as an early indicator for developmental delays. However, the observation of children interacting with toys for the purpose of quantitative analysis can be a difficult task. To better quantify how play may serve as an early indicator, researchers have conducted retrospective studies examining the differences in object play behaviors among infants. However, such studies require that researchers repeatedly inspect videos of play often at speeds much slower than real-time to indicate points of interest. The research presented in this dissertation examines whether a combination of sensors embedded within toys and automatic pattern recognition of object play behaviors can help expedite this process. For my dissertation, I developed the Child'sPlay system which uses augmented toys and statistical models to automatically provide quantitative measures of object play interactions, as well as, provide the PlayView interface to view annotated play data for later analysis. In this dissertation, I examine the hypothesis that sensors embedded in objects can provide sufficient data for automatic recognition of certain exploratory, relational, and functional object play behaviors in semi-naturalistic environments and that a continuum of recognition accuracy exists which allows automatic indexing to be useful for retrospective review. I designed several augmented toys and used them to collect object play data from more than fifty play sessions. I conducted pattern recognition experiments over this data to produce statistical models that automatically classify children's object play behaviors. In addition, I conducted a user study with twenty participants to determine if annotations automatically generated from these models help improve performance in retrospective review tasks. My results indicate that these statistical models increase user performance and decrease perceived effort when combined with the PlayView interface during retrospective review. The presence of high quality annotations are preferred by users and promotes an increase in the effective retrieval rates of object play behaviors.Ph.D.Committee Chair: Starner, Thad E.; Committee Co-Chair: Abowd, Gregory D.; Committee Member: Arriaga, Rosa; Committee Member: Jackson, Melody Moore; Committee Member: Lukowicz, Paul; Committee Member: Rehg, James M

Data Mining in Internet of Things Systems: A Literature Review

The Internet of Things (IoT) and cloud technologies have been the main focus of recent research, allowing for the accumulation of a vast amount of data generated from this diverse environment. These data include without any doubt priceless knowledge if could correctly discovered and correlated in an efficient manner. Data mining algorithms can be applied to the Internet of Things (IoT) to extract hidden information from the massive amounts of data that are generated by IoT and are thought to have high business value. In this paper, the most important data mining approaches covering classification, clustering, association analysis, time series analysis, and outlier analysis from the knowledge will be covered. Additionally, a survey of recent work in in this direction is included. Another significant challenges in the field are collecting, storing, and managing the large number of devices along with their associated features. In this paper, a deep look on the data mining for the IoT platforms will be given concentrating on real applications found in the literatur

Pattern Recognition

Pattern recognition is a very wide research field. It involves factors as diverse as sensors, feature extraction, pattern classification, decision fusion, applications and others. The signals processed are commonly one, two or three dimensional, the processing is done in real- time or takes hours and days, some systems look for one narrow object class, others search huge databases for entries with at least a small amount of similarity. No single person can claim expertise across the whole field, which develops rapidly, updates its paradigms and comprehends several philosophical approaches. This book reflects this diversity by presenting a selection of recent developments within the area of pattern recognition and related fields. It covers theoretical advances in classification and feature extraction as well as application-oriented works. Authors of these 25 works present and advocate recent achievements of their research related to the field of pattern recognition

Efficient Sparse Bayesian Learning using Spike-and-Slab Priors

In the context of statistical machine learning, sparse learning is a procedure that seeks a reconciliation between two competing aspects of a statistical model: good predictive power and interpretability. In a Bayesian setting, sparse learning methods invoke sparsity inducing priors to explicitly encode this tradeoff in a principled manner