Factors that affected the efficacy of nonsurgical periodontal treatment carried out by postgraduate periodontology students

The training of postgraduate students in periodontology has a significant clinical impact. The overall assessment of the efficacy of non-surgical treatment of periodontitis, has value to inform training protocols as well as assess the quality of clinical service delivery. Furthermore, obstacles to successful treatment can be identified. The aim of the study was to determine the effectiveness of non-surgical periodontal treatment, as well as the factors that may determine treatment outcome at the postgraduate clinic in the Periodontology Department at the University of the Western Cape, Tygerberg Dental Hospital, between 2016 and 2018. A cross-sectional record-based study of 100 patients was conducted. Demographic, social, clinical, treatment data were obtained from the hospital files. Periodontal parameters including bleeding index (BI), Pocket Probing depth (PPD), Plaque index (PI), and clinical attachment level (CAL), were recorded at the initial visit (Pre-treatment) and follow-up visits (Post-treatment), and the final treatment outcomes were calculated based on the differences of these parameters’ values between the initial visit and the last follow-up visit. Data were presented as mean and range for continuous variables and as a frequency for categorical variables. Statistical analyses were performed to determine if there was a relationship between the varied factors and treatment outcome with p < 0.05 as statistically significant. The results showed that all 100 patients demonstrated a marked reduction in PPD, PI, BI, and loss of CAL. The overall mean PPD reduction was 0.32 (0.5), the mean reduction in PI and BI were 37.2 (24.08) and 34.61 (22.78), respectively, and the mean clinical attachment gain was 0.42 (0.97) mm. Treatment outcome showed no differencein PPD, PI, BI, and CAL between females, smokers, and patients with systemic conditions compared to males, non smokers, and patients without systemic conditions. On the other hand, patients who underwent more maintenance treatment visits over a period longer than 2 months duration had significantly better outcomes compared to patients who had less than two months of duration of treatment. This study proved the effectiveness of the non-surgical surgical periodontal treatment at the postgraduate periodontal clinic. Treatment duration and frequency of recall visits were the most influential factor impacting the treatment outcome

Continuum Belief, Categorical Belief, and Depression Stigma: Correlational Evidence and Outcomes of an Online Intervention

Continuum belief interventions that erode boundaries between “normal” individuals and individuals with psychiatric problems may help to reduce psychiatric stigma, but a number of questions persist. The magnitude of belief change attributable to the intervention is unclear. Moreover, most studies have executed continuum interventions to reduce stigma of schizophrenia, and all studies have examined intervention effects on only public stigma. This study utilized a large sample (n = 654) to examine effects of a continuum intervention on depression stigma—public stigma in the full sample and self-stigma among participants with a self-reported history of depression. Participants were randomly assigned to one of three intervention groups: (a) the control group, which read material that merely described depression, (b) the continuum group, which read material that attested to a continuum view of depression, or (c) the categorical group, which read material that attested to a categorical view of depression. Correlational analyses demonstrated that preintervention categorical belief positively predicted, and preintervention continuum belief negatively predicted, depression stigma. Moreover, preintervention categorical belief positively predicted, and preintervention continuum belief negatively predicted, self-stigma among participants with a self-reported history of depression. There was scant evidence that the intervention affected public stigma among participants without a history of depression and no evidence that it affected self-stigma among participants with a history of depression. These findings illuminate a number of key priorities for future research on continuum belief intervention and its prospects for stigma reduction

Cognitive processes in categorical and associative priming: a diffusion model analysis

Cognitive processes and mechanisms underlying different forms of priming were investigated using a diffusion model approach. In a series of 6 experiments, effects of prime-target associations and of a semantic and affective categorical match of prime and target were analyzed for different tasks. Significant associative and categorical priming effects were found in standard analyses of response times (RTs) and error frequencies. Results of diffusion model analyses revealed that priming effects of associated primes were mapped on the drift rate parameter (v), while priming effects of a categorical match on a task-relevant dimension were mapped on the extradecisional parameters (t(0) and d). These results support a spreading activation account of associative priming and an explanation of categorical priming in terms of response competition. Implications for the interpretation of priming effects and the use of priming paradigms in cognitive psychology and social cognition are discussed

Genomics analysis on the responses of E. coli cells to varying environmental conditions

The natural living environments of E. coli cells are diverse, varying from mammalian gastrointestinal tracts and soil. Each environment might require distinct metabolic pathways and transporter systems, and long-term evolution has established elaborate regulatory system for E. coli cells to quickly adapt to the changing conditions. Sensing outside stresses and then adopting a different phenotype enable them to take advantage of any possible nutrients and defend against hostile environment. A lot of regulatory mechanisms have been identified by genetic, biochemical and molecular biology methods, and our study aim to build a systematic view on the response of the whole genome to four different environmental conditions. We used statistical tests including Pearson’s tests and Spearman’s tests and multiple testing adjustments to identify feature genes that are induced or repressed significantly across treatment levels. The feature genes identified were partially supported by previous literatures, and some of the novel genes not found in any previous studies may infer a potential research blind spot. Additionally, we compared the correlation tests to the implementation of machine learning algorithms, and discussed the advantage and drawbacks of each method.Statistic

Β-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells

Β-blockers (BB) are a primary treatment for chronic heart disease (CHD), resulting in prognostic and symptomatic benefits. Cardiac cell therapy represents a promising regenerative treatment and, for autologous cell therapy, the patients clinical history may correlate with the biology of resident progenitors and the quality of the final cell product. This study aimed at uncovering correlations between clinical records of biopsy-donor CHD patients undergoing cardiac surgery and the corresponding yield and phenotype of cardiospheres (CSs) and CS-derived cells (CDCs), which are a clinically relevant population for cell therapy, containing progenitors. We describe a statistically significant association between BB therapy and improved CSs yield and CDCs phenotype. We show that BB-CDCs have a reduced fibrotic-like CD90 + subpopulation, with reduced expression of collagen-I and increased expression of cardiac genes, compared to CDCs from non-BB donors. Moreover BB-CDCs had a distinctive microRNA expression profile, consistent with reduced fibrotic features (miR-21, miR-29a/b/c downregulation), and enhanced regenerative potential (miR-1, miR-133, miR-101 upregulation) compared to non-BB. In vitro adrenergic pharmacological treatments confirmed cytoprotective and anti-fibrotic effects of β1-blocker on CDCs. This study shows anti-fibrotic and pro-commitment effects of BB treatment on endogenous cardiac reparative cells, and suggests adjuvant roles of β-blockers in cell therapy applications