Sparse and Redundant Representations for Inverse Problems and Recognition

Sparse and redundant representation of data enables the description of signals as linear combinations of a few atoms from a dictionary. In this dissertation, we study applications of sparse and redundant representations in inverse problems and object recognition. Furthermore, we propose two novel imaging modalities based on the recently introduced theory of Compressed Sensing (CS). This dissertation consists of four major parts. In the first part of the dissertation, we study a new type of deconvolution algorithm that is based on estimating the image from a shearlet decomposition. Shearlets provide a multi-directional and multi-scale decomposition that has been mathematically shown to represent distributed discontinuities such as edges better than traditional wavelets. We develop a deconvolution algorithm that allows for the approximation inversion operator to be controlled on a multi-scale and multi-directional basis. Furthermore, we develop a method for the automatic determination of the threshold values for the noise shrinkage for each scale and direction without explicit knowledge of the noise variance using a generalized cross validation method. In the second part of the dissertation, we study a reconstruction method that recovers highly undersampled images assumed to have a sparse representation in a gradient domain by using partial measurement samples that are collected in the Fourier domain. Our method makes use of a robust generalized Poisson solver that greatly aids in achieving a significantly improved performance over similar proposed methods. We will demonstrate by experiments that this new technique is more flexible to work with either random or restricted sampling scenarios better than its competitors. In the third part of the dissertation, we introduce a novel Synthetic Aperture Radar (SAR) imaging modality which can provide a high resolution map of the spatial distribution of targets and terrain using a significantly reduced number of needed transmitted and/or received electromagnetic waveforms. We demonstrate that this new imaging scheme, requires no new hardware components and allows the aperture to be compressed. Also, it presents many new applications and advantages which include strong resistance to countermesasures and interception, imaging much wider swaths and reduced on-board storage requirements. The last part of the dissertation deals with object recognition based on learning dictionaries for simultaneous sparse signal approximations and feature extraction. A dictionary is learned for each object class based on given training examples which minimize the representation error with a sparseness constraint. A novel test image is then projected onto the span of the atoms in each learned dictionary. The residual vectors along with the coefficients are then used for recognition. Applications to illumination robust face recognition and automatic target recognition are presented

3D exemplar-based image inpainting in electron microscopy

In electron microscopy (EM) a common problem is the non-availability of data, which causes artefacts in reconstructions. In this thesis the goal is to generate artificial data where missing in EM by using exemplar-based inpainting (EBI). We implement an accelerated 3D version tailored to applications in EM, which reduces reconstruction times from days to minutes. We develop intelligent sampling strategies to find optimal data as input for reconstruction methods. Further, we investigate approaches to reduce electron dose and acquisition time. Sparse sampling followed by inpainting is the most promising approach. As common evaluation measures may lead to misinterpretation of results in EM and falsify a subsequent analysis, we propose to use application driven metrics and demonstrate this in a segmentation task. A further application of our technique is the artificial generation of projections in tiltbased EM. EBI is used to generate missing projections, such that the full angular range is covered. Subsequent reconstructions are significantly enhanced in terms of resolution, which facilitates further analysis of samples. In conclusion, EBI proves promising when used as an additional data generation step to tackle the non-availability of data in EM, which is evaluated in selected applications. Enhancing adaptive sampling methods and refining EBI, especially considering the mutual influence, promotes higher throughput in EM using less electron dose while not lessening quality.Ein häufig vorkommendes Problem in der Elektronenmikroskopie (EM) ist die Nichtverfügbarkeit von Daten, was zu Artefakten in Rekonstruktionen führt. In dieser Arbeit ist es das Ziel fehlende Daten in der EM künstlich zu erzeugen, was durch Exemplar-basiertes Inpainting (EBI) realisiert wird. Wir implementieren eine auf EM zugeschnittene beschleunigte 3D Version, welche es ermöglicht, Rekonstruktionszeiten von Tagen auf Minuten zu reduzieren. Wir entwickeln intelligente Abtaststrategien, um optimale Datenpunkte für die Rekonstruktion zu erhalten. Ansätze zur Reduzierung von Elektronendosis und Aufnahmezeit werden untersucht. Unterabtastung gefolgt von Inpainting führt zu den besten Resultaten. Evaluationsmaße zur Beurteilung der Rekonstruktionsqualität helfen in der EM oft nicht und können zu falschen Schlüssen führen, weswegen anwendungsbasierte Metriken die bessere Wahl darstellen. Dies demonstrieren wir anhand eines Beispiels. Die künstliche Erzeugung von Projektionen in der neigungsbasierten Elektronentomographie ist eine weitere Anwendung. EBI wird verwendet um fehlende Projektionen zu generieren. Daraus resultierende Rekonstruktionen weisen eine deutlich erhöhte Auflösung auf. EBI ist ein vielversprechender Ansatz, um nicht verfügbare Daten in der EM zu generieren. Dies wird auf Basis verschiedener Anwendungen gezeigt und evaluiert. Adaptive Aufnahmestrategien und EBI können also zu einem höheren Durchsatz in der EM führen, ohne die Bildqualität merklich zu verschlechtern

Mathematical Challenges in Electron Microscopy

Development of electron microscopes first started nearly 100 years ago and they are now a mature imaging modality with many applications and vast potential for the future. The principal feature of electron microscopes is their resolution; they can be up to 1000 times more powerful than a visible light microscope and resolve even the smallest atoms. Furthermore, electron microscopes are also sensitive to many material properties due to the very rich interactions between electrons and other matter. Because of these capabilities, electron microscopy is used in applications as diverse as drug discovery, computer chip manufacture, and the development of solar cells. In parallel to this, the mathematical field of inverse problems has also evolved dramatically. Many new methods have been introduced to improve the recovery of unknown structures from indirect data, typically an ill-posed problem. In particular, sparsity promoting functionals such as the total variation and its extensions have been shown to be very powerful for recovering accurate physical quantities from very little and/or poor quality data. While sparsity-promoting reconstruction methods are powerful, they can also be slow, especially in a big-data setting. This trade-off forms an eternal cycle as new numerical tools are found and more powerful models are developed. The work presented in this thesis aims to marry the tools of inverse problems with the problems of electron microscopy: bringing state-of-the-art image processing techniques to bear on challenges specific to electron microscopy, developing new optimisation methods for these problems, and modelling new inverse problems to extend the capabilities of existing microscopes. One focus is the application of a directional total variation to overcome the limited angle problem in electron tomography, another is the proposal of a new inverse problem for the reconstruction of 3D strain tensor fields from electron microscopy diffraction data. The remaining contributions target numerical aspects of inverse problems, from new algorithms for non-convex problems to convex optimisation with adaptive meshes.Cantab Capital Institute for Mathematics of Informatio

Advanced Techniques for Ground Penetrating Radar Imaging

Ground penetrating radar (GPR) has become one of the key technologies in subsurface sensing and, in general, in non-destructive testing (NDT), since it is able to detect both metallic and nonmetallic targets. GPR for NDT has been successfully introduced in a wide range of sectors, such as mining and geology, glaciology, civil engineering and civil works, archaeology, and security and defense. In recent decades, improvements in georeferencing and positioning systems have enabled the introduction of synthetic aperture radar (SAR) techniques in GPR systems, yielding GPR–SAR systems capable of providing high-resolution microwave images. In parallel, the radiofrequency front-end of GPR systems has been optimized in terms of compactness (e.g., smaller Tx/Rx antennas) and cost. These advances, combined with improvements in autonomous platforms, such as unmanned terrestrial and aerial vehicles, have fostered new fields of application for GPR, where fast and reliable detection capabilities are demanded. In addition, processing techniques have been improved, taking advantage of the research conducted in related fields like inverse scattering and imaging. As a result, novel and robust algorithms have been developed for clutter reduction, automatic target recognition, and efficient processing of large sets of measurements to enable real-time imaging, among others. This Special Issue provides an overview of the state of the art in GPR imaging, focusing on the latest advances from both hardware and software perspectives

Sensor Signal and Information Processing II

In the current age of information explosion, newly invented technological sensors and software are now tightly integrated with our everyday lives. Many sensor processing algorithms have incorporated some forms of computational intelligence as part of their core framework in problem solving. These algorithms have the capacity to generalize and discover knowledge for themselves and learn new information whenever unseen data are captured. The primary aim of sensor processing is to develop techniques to interpret, understand, and act on information contained in the data. The interest of this book is in developing intelligent signal processing in order to pave the way for smart sensors. This involves mathematical advancement of nonlinear signal processing theory and its applications that extend far beyond traditional techniques. It bridges the boundary between theory and application, developing novel theoretically inspired methodologies targeting both longstanding and emergent signal processing applications. The topic ranges from phishing detection to integration of terrestrial laser scanning, and from fault diagnosis to bio-inspiring filtering. The book will appeal to established practitioners, along with researchers and students in the emerging field of smart sensors processing

Elevation and Deformation Extraction from TomoSAR

3D SAR tomography (TomoSAR) and 4D SAR differential tomography (Diff-TomoSAR) exploit multi-baseline SAR data stacks to provide an essential innovation of SAR Interferometry for many applications, sensing complex scenes with multiple scatterers mapped into the same SAR pixel cell. However, these are still influenced by DEM uncertainty, temporal decorrelation, orbital, tropospheric and ionospheric phase distortion and height blurring. In this thesis, these techniques are explored. As part of this exploration, the systematic procedures for DEM generation, DEM quality assessment, DEM quality improvement and DEM applications are first studied. Besides, this thesis focuses on the whole cycle of systematic methods for 3D & 4D TomoSAR imaging for height and deformation retrieval, from the problem formation phase, through the development of methods to testing on real SAR data. After DEM generation introduction from spaceborne bistatic InSAR (TanDEM-X) and airborne photogrammetry (Bluesky), a new DEM co-registration method with line feature validation (river network line, ridgeline, valley line, crater boundary feature and so on) is developed and demonstrated to assist the study of a wide area DEM data quality. This DEM co-registration method aligns two DEMs irrespective of the linear distortion model, which improves the quality of DEM vertical comparison accuracy significantly and is suitable and helpful for DEM quality assessment. A systematic TomoSAR algorithm and method have been established, tested, analysed and demonstrated for various applications (urban buildings, bridges, dams) to achieve better 3D & 4D tomographic SAR imaging results. These include applying Cosmo-Skymed X band single-polarisation data over the Zipingpu dam, Dujiangyan, Sichuan, China, to map topography; and using ALOS L band data in the San Francisco Bay region to map urban building and bridge. A new ionospheric correction method based on the tile method employing IGS TEC data, a split-spectrum and an ionospheric model via least squares are developed to correct ionospheric distortion to improve the accuracy of 3D & 4D tomographic SAR imaging. Meanwhile, a pixel by pixel orbit baseline estimation method is developed to address the research gaps of baseline estimation for 3D & 4D spaceborne SAR tomography imaging. Moreover, a SAR tomography imaging algorithm and a differential tomography four-dimensional SAR imaging algorithm based on compressive sensing, SAR interferometry phase (InSAR) calibration reference to DEM with DEM error correction, a new phase error calibration and compensation algorithm, based on PS, SVD, PGA, weighted least squares and minimum entropy, are developed to obtain accurate 3D & 4D tomographic SAR imaging results. The new baseline estimation method and consequent TomoSAR processing results showed that an accurate baseline estimation is essential to build up the TomoSAR model. After baseline estimation, phase calibration experiments (via FFT and Capon method) indicate that a phase calibration step is indispensable for TomoSAR imaging, which eventually influences the inversion results. A super-resolution reconstruction CS based study demonstrates X band data with the CS method does not fit for forest reconstruction but works for reconstruction of large civil engineering structures such as dams and urban buildings. Meanwhile, the L band data with FFT, Capon and the CS method are shown to work for the reconstruction of large manmade structures (such as bridges) and urban buildings

Design patterns and software techniques for large-scale, open and reproducible data reduction

The preparation for the construction of the Square Kilometre Array, and the introduction of its operational precursors, such as LOFAR and MeerKAT, mark the beginning of an exciting era for astronomy. Impressive new data containing valuable science just waiting for discovery is already being generated, and these devices will produce far more data than has ever been collected before. However, with every new data instrument, the data rates grow to unprecedented quantities of data, requiring novel new data-processing tools. In addition, creating science grade data from the raw data still requires significant expert knowledge for processing this data. The software used is often developed by a scientist who lacks proper training in software development skills, resulting in the software not progressing beyond a prototype stage in quality. In the first chapter, we explore various organisational and technical approaches to address these issues by providing a historical overview of the development of radioastronomy pipelines since the inception of the field in the 1940s. In that, the steps required to create a radio image are investigated. We used the lessons-learned to identify patterns in the challenges experienced, and the solutions created to address these over the years. The second chapter describes the mathematical foundations that are essential for radio imaging. In the third chapter, we discuss the production of the KERN Linux distribution, which is a set of software packages containing most radio astronomy software currently in use. Considerable effort was put into making sure that the contained software installs appropriately, all items next to one other on the same system. Where required and possible, bugs and portability fixes were solved and reported with the upstream maintainers. The KERN project also has a website, and issue tracker, where users can report bugs and maintainers can coordinate the packaging effort and new releases. The software packages can be used inside Docker and Singularity containers, enabling the installation of these packages on a wide variety of platforms. In the fourth and fifth chapters, we discuss methods and frameworks for combining the available data reduction tools into recomposable pipelines and introduce the Kliko specification and software. This framework was created to enable end-user astronomers to chain and containerise operations of software in KERN packages. Next, we discuss the Common Workflow Language (CommonWL), a similar but more advanced and mature pipeline framework invented by bio-informatics scientists. CommonWL is supported by a wide range of tools already; among other schedulers, visualisers and editors. Consequently, when a pipeline is made with CommonWL, it can be deployed and manipulated with a wide range of tools. In the final chapter, we attempt something unconventional, applying a generative adversarial network based on deep learning techniques to perform the task of sky brightness reconstruction. Since deep learning methods often require a large number of training samples, we constructed a CommonWL simulation pipeline for creating dirty images and corresponding sky models. This simulated dataset has been made publicly available as the ASTRODECONV2019 dataset. It is shown that this method is useful to perform the restoration and matches the performance of a single clean cycle. In addition, we incorporated domain knowledge by adding the point spread function to the network and by utilising a custom loss function during training. Although it was not possible to improve the cleaning performance of commonly used existing tools, the computational time performance of the approach looks very promising. We suggest that a smaller scope should be the starting point for further studies and optimising of the training of the neural network could produce the desired results

Deep learning-based improvement for the outcomes of glaucoma clinical trials

Glaucoma is the leading cause of irreversible blindness worldwide. It is a progressive optic neuropathy in which retinal ganglion cell (RGC) axon loss, probably as a consequence of damage at the optic disc, causes a loss of vision, predominantly affecting the mid-peripheral visual field (VF). Glaucoma results in a decrease in vision-related quality of life and, therefore, early detection and evaluation of disease progression rates is crucial in order to assess the risk of functional impairment and to establish sound treatment strategies. The aim of my research is to improve glaucoma diagnosis by enhancing state of the art analyses of glaucoma clinical trial outcomes using advanced analytical methods. This knowledge would also help better design and analyse clinical trials, providing evidence for re-evaluating existing medications, facilitating diagnosis and suggesting novel disease management. To facilitate my objective methodology, this thesis provides the following contributions: (i) I developed deep learning-based super-resolution (SR) techniques for optical coherence tomography (OCT) image enhancement and demonstrated that using super-resolved images improves the statistical power of clinical trials, (ii) I developed a deep learning algorithm for segmentation of retinal OCT images, showing that the methodology consistently produces more accurate segmentations than state-of-the-art networks, (iii) I developed a deep learning framework for refining the relationship between structural and functional measurements and demonstrated that the mapping is significantly improved over previous techniques, iv) I developed a probabilistic method and demonstrated that glaucomatous disc haemorrhages are influenced by a possible systemic factor that makes both eyes bleed simultaneously. v) I recalculated VF slopes, using the retinal never fiber layer thickness (RNFLT) from the super-resolved OCT as a Bayesian prior and demonstrated that use of VF rates with the Bayesian prior as the outcome measure leads to a reduction in the sample size required to distinguish treatment arms in a clinical trial