2 research outputs found
Gradient waveform design for tensor-valued encoding in diffusion MRI
Diffusion encoding along multiple spatial directions per signal acquisition
can be described in terms of a b-tensor. The benefit of tensor-valued diffusion
encoding is that it unlocks the "shape of the b-tensor" as a new encoding
dimension. By modulating the b-tensor shape, we can control the sensitivity to
microscopic diffusion anisotropy which can be used as a contrast mechanism; a
feature that is inaccessible by conventional diffusion encoding. Since imaging
methods based on tensor-valued diffusion encoding are finding an increasing
number of applications we are prompted to highlight the challenge of designing
the optimal gradient waveforms for any given application. In this review, we
first establish the basic design objectives in creating field gradient
waveforms for tensor-valued diffusion MRI. We also survey additional design
considerations related to limitations imposed by hardware and physiology,
potential confounding effects that cannot be captured by the b-tensor, and
artifacts related to the diffusion encoding waveform. Throughout, we discuss
the expected compromises and tradeoffs with an aim to establish a more complete
understanding of gradient waveform design and its impact on accurate
measurements and interpretations of data.Comment: Invited review, submitted in May 2020 to the Journal of Neuroscience
Methods. 46 pages, 9 figures, 35 equation
A 4D Basis and Sampling Scheme for the Tensor Encoded Multi-Dimensional Diffusion MRI Signal
International audienceWe propose a 4-dimensional (4D) basis and sampling scheme, along with a corresponding reconstruction algorithm, for the measurement and reconstruction of the b-tensor encoded diffusion signal in diffusion magnetic resonance imaging (MRI). This is only the second basis proposed for representing the b-tensor encoded diffusion signal and the first to allow for planar tensor measurements. We design a sampling scheme that attains an efficient number of samples, equal to the degrees of freedom required to represent the diffusion signal in the proposed 4D basis. The properties of the diffusion signal are studied to provide recommendations on how many b-tensor measurements to use. Evaluation of the proposed scheme using Monte Carlo simulations of the diffusion signal is done to show that the proposed scheme gives accurate interpolation of the signal