Renaissance mercurial therapy in the mummies of Saint Domenico Maggiore in Naples: a palaeopathological and palaeotoxicological approach

AbstractThis study was designed to evaluate the use of mercury therapy in the Italian noble classes of the Renaissance through the toxicological analysis of hair content. Mercury has stability and a long half-life in hair, representing a great resource not only for forensic toxicological analysis but also for archaeological research on mercurial exposure in past populations. The hair of fourteen mummified individuals of the Aragon and vice-royal court of Naples, buried in the Neapolitan Basilica of Saint Domenico Maggiore (15–18th centuries), was analysed by atomic absorption spectroscopy (AAS) and flame emission spectroscopy (FES). Out of the fourteen individuals, four presented mercury concentrations in the hair washing liquid indicating external perimortem application (in one case clearly linked to embalming, in three cases probably associated with topical therapeutic practices), three showed no traces of mercury, and seven had mercury values in hair ranging from 411 to 47 ppm, which indicate prolonged exposure in life to the metal. The historical identification of most of the mummified bodies with important nobles of Naples has allowed to compare the toxicological analyses with the nosography of the individuals and with the palaeopathological results deriving from the direct study of their bodies. Prolonged exposure in life to the metal was most likely due to mercurial anti-syphilitic therapy, as a consequence of its indiscriminate use in Renaissance therapies and, indirectly, as an effect of the extraordinary spread of venereal syphilis in the Italian upper classes during the "epidemic" phase of the disease

A 16th century Escherichia coli draft genome associated with an opportunistic bile infection

Escherichia coli – one of the most characterized bacteria and a major public health concern – remains invisible across the temporal landscape. Here, we present the meticulous reconstruction of the first ancient E. coli genome from a 16(th) century gallstone from an Italian mummy with chronic cholecystitis. We isolated ancient DNA and reconstructed the ancient E. coli genome. It consisted of one chromosome of 4446 genes and two putative plasmids with 52 genes. The E. coli strain belonged to the phylogroup A and an exceptionally rare sequence type 4995. The type VI secretion system component genes appears to be horizontally acquired from Klebsiella aerogenes, however we could not identify any pathovar specific genes nor any acquired antibiotic resistances. A sepsis mouse assay showed that a closely related contemporary E. coli strain was avirulent. Our reconstruction of this ancient E. coli helps paint a more complete picture of the burden of opportunistic infections of the past

A rhinopristiform sawfish (genus Pristis) from the middle Eocene (Lutetian) of southern Peru and its regional implications

Modern sawfishes Rhinopristiformes: Pristidae are circumglobally distributed in warm waters and are common in proximal marine and even freshwater habitats. The fossil record of modern pristid genera i.e., Pristis and Anoxypristis dates back to the early Eocene and is mostly represented by isolated rostral spines and oral teeth, with phosphatised rostra representing exceptional occurrences. Here, we report on a partial pristid rostrum, exhibiting several articulated rostral spines, from middle Eocene strata of the Paracas Formation Yumaque Member exposed in the southern Peruvian East Pisco Basin. This finely preserved specimen shows anatomical structures that are unlikely to leave a fossil record, e.g., the paracentral grooves that extend along the ventral surface of the rostrum. Based on the morphology of the rostral spines, this fossil sawfish is here identified as belonging to Pristis. To our knowledge, this discovery represents the geologically oldest known occurrence of Pristidae from the Pacific Coast of South America. Although the fossil record of pristids from the East Pisco Basin spans from the middle Eocene to the late Miocene, sawfishes are no longer present in the modern cool, upwelling-influenced coastal waters of southern Peru. Given the ecological preferences of the extant members of Pristis, the occurrence of this genus in the Paracas deposits suggests that middle Eocene nearshore waters in southern Peru were warmer than today. The eventual disappearance of pristids from the coastal waters off southern Peru might be interpreted as reflecting the late Cenozoic trend of strengthening of the Humboldt Current

A rhinopristiform sawfish (Genus pristis) from the middle eocene (lutetian) of southern Peru and its regional implications

Modern sawfishes (Rhinopristiformes: Pristidae) are circumglobally distributed in warm waters and are common in proximal marine and even freshwater habitats. The fossil record of modern pristid genera (i.e., Pristis and Anoxypristis) dates back to the early Eocene and is mostly represented by isolated rostral spines and oral teeth, with phosphatised rostra representing exceptional occurrences. Here, we report on a partial pristid rostrum, exhibiting several articulated rostral spines, from middle Eocene strata of the Paracas Formation (Yumaque Member) exposed in the southern Peruvian East Pisco Basin. This finely preserved specimen shows anatomical structures that are unlikely to leave a fossil record, e.g., the paracentral grooves that extend along the ventral surface of the rostrum. Based on the morphology of the rostral spines, this fossil sawfish is here identified as belonging to Pristis. To our knowledge, this discovery represents the geologically oldest known occurrence of Pristidae from the Pacific Coast of South America. Although the fossil record of pristids from the East Pisco Basin spans from the middle Eocene to the late Miocene, sawfishes are no longer present in the modern cool, upwelling-influenced coastal waters of southern Peru. Given the ecological preferences of the extant members of Pristis, the occurrence of this genus in the Paracas deposits suggests that middle Eocene nearshore waters in southern Peru were warmer than today. The eventual disappearance of pristids from the coastal waters off southern Peru might be interpreted as reflecting the late Cenozoic trend of strengthening of the Humboldt Current

Subdaily meteorological measurements of temperature, direction of the movement of the clouds, and cloud cover in the Late Maunder Minimum by Louis Morin in Paris

We have digitized three meteorological variables (temperature, direction of the movement of the clouds, and cloud cover) from copies of Louis Morin’s original measurements (source: Institute of History/Oeschger Centre for Climate Change Research, University of Bern; Institut de France) and subjected them to quality analysis to make these data available to the scientific community. Our available data cover the period 1665–1713 (temperature beginning in 1676). We compare the early instrumental temperature dataset with statistical methods and proxy data to validate the measurements in terms of inhomogeneities and claim that they are, apart from small inhomogeneities, reliable. The Late Maunder Minimum (LMM) is characterized by cold winters and falls and moderate springs and summers with respect to the reference period of 1961–1990. Winter months show a significantly lower frequency of the westerly direction in the movement of the clouds. This reduction of advection from the ocean leads to a cooling in Paris in winter. The influence of the advection becomes apparent when comparing the last decade of the 17th century (cold) and the first decade of the 18th century (warm). Consequently, the unusually cold winters in the LMM are largely caused by a lower frequency of the westerly direction in the movement of the clouds. An impact analysis reveals that the winter of 1708/09 was a devastating one with respect to consecutive ice days, although other winters are more pronounced (e.g., the winters of 1676/77, 1678/79, 1683/84, 1692/93, 1694/95, and 1696/97) in terms of mean temperature, ice days, cold days, or consecutive cold days. An investigation of the cloud cover data revealed a high discrepancy, with the winter season (DJF, -14.0 %), the spring season (MAM, -20.8 %), the summer season (JJA, -17.9 %), and the fall season (SON, -18.0 %) showing negative anomalies of total cloud cover (TCC) with respect to the 30-year mean of the ERA5 data (1981–2010). Thus, Morin’s measurements of temperature and direction of the movement of the clouds seem to be trustworthy, whereas cloud cover in quantitative terms should be taken with caution

Improving Sustainable Mobility through Modal Rewarding: The GOOD_GO Smart Platform

Private car mobility registers today a h igh accident rate and around 70% of the overall CO2 emissions from transport were generated by road mode split (European Commission, 2016). Moreover, in urban areas they occur 38% of the overall fatalities from road transport, and 23% of the overall CO2 emissions (European Commission, 2013). As a result, a modal shift of at least a part of passenger transport in urban areas, from private car to sustainable transport systems is desirable. This research aims to promote sustainable mobility through two mutually reinforcing "main actions": firstly, there is a r ewarding Open-Source platform, named as GOOD_GO; secondly, there is the SW/HW system connecting to the wide world of private and/or shared bicycles. Through the GOOD_GO platform Web portal and App, a user enters a so called 'social rewarding game' thought to incentive sustainable mobility habits, and gets access to the second item consisting of a system to disincentive bike-theft and based on the passive RFID technology. The low-cost deterrent bike-theft and bike monitoring/tracking system is functional to bring a big number of citizens inside the rewarding game. In 2018, a pilot test has implemented in the city of Livorno (Tuscany, It), and it involved around 1,000 citizens. Results were quite encouraging and today, the cities of Livorno, Pisa and Bolzano will enlarge the incentive system both to home-to-school and home-to-work mobility. The Good_Go platform is an actual M-a-a-S (Mobility-as-a-Service) application, and it becoming a Mobility Management decision system support, jointly with the opportunity of organizing more incentive tenders and rewarding systems types

Architecture and performance of the KM3NeT front-end firmware

The authors acknowledge the financial support of the funding agencies: Agence Nationale de la Recherche (contract ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Paris Ile-de-France Region, France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG, FR-18-1268), Georgia; Deutsche Forschungsgemeinschaft (DFG), Germany; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), PRIN 2017 program (Grant NAT-NET 2017W4HA7S) Italy; Ministry of Higher Education Scientific Research and Professional Training, ICTP through Grant AF-13, Morocco; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; The National Science Centre, Poland (2015/18/E/ST2/00758); National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), Junta de Andalucia (ref. SOMM17/6104/UGR), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119) and GenT (ref. CIDEGENT/2018/034) programs, La Caixa Foundation (ref. LCF/BQ/IN17/11620019), EU: MSC program (ref. 713673), Spain.The KM3NeT infrastructure consists of two deep-sea neutrino telescopes being deployed in the Mediterranean Sea. The telescopes will detect extraterrestrial and atmospheric neutrinos by means of the incident photons induced by the passage of relativistic charged particles through the seawater as a consequence of a neutrino interaction. The telescopes are configured in a three-dimensional grid of digital optical modules, each hosting 31 photomultipliers. The photomultiplier signals produced by the incident Cherenkov photons are converted into digital information consisting of the integrated pulse duration and the time at which it surpasses a chosen threshold. The digitization is done by means of time to digital converters (TDCs) embedded in the field programmable gate array of the central logic board. Subsequently, a state machine formats the acquired data for its transmission to shore. We present the architecture and performance of the front-end firmware consisting of the TDCs and the state machine.French National Research Agency (ANR) ANR-15-CE31-0020Centre National de la Recherche Scientifique (CNRS)Commission Europeenne (FEDER fund), FranceCommission Europeenne (Marie Curie Program), FranceInstitut Universitaire de France (IUF), FranceLabEx UnivEarthS, France ANR-10-LABX-0023 ANR-18-IDEX-0001Paris Ile-de-France Region, FranceShota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268German Research Foundation (DFG)Greek Ministry of Development-GSRTIstituto Nazionale di Fisica Nucleare (INFN) NAT-NET 2017W4HA7SMinistry of Education, Universities and Research (MIUR) NAT-NET 2017W4HA7SPRIN 2017 program Italy NAT-NET 2017W4HA7SMinistry of Higher Education Scientific Research and Professional Training, ICTP, Morocco AF-13Netherlands Organization for Scientific Research (NWO) Netherlands GovernmentNational Science Centre, Poland 2015/18/E/ST2/00758National Authority for Scientific Research (ANCS), RomaniaMinisterio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (MCIU/FEDER), Spain PGC2018-096663-B-C41 PGC2018-096663-A-C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), SpainJunta de Andalucia European Commission SOMM17/6104/UGRGeneralitat Valenciana: Grisolia program, Spain GRISOLIA/2018/119Generalitat Valenciana: GenT program, Spain CIDEGENT/2018/034La Caixa Foundation LCF/BQ/IN17/11620019EU: MSC program, Spain 71367

Social Justice in the EU – Index Report 2016 Social Inclusion Monitor Europe

1. Social justice in the EU – participation opportunities have improved in the majority of EU member states, but are still a long way behind precrisis levels Social justice has improved slightly in the majority of EU member states compared with last year’s Social Justice Index (SJI 2015). It appears that, after years of decline, the majority of countries reached their lowest point between 2012 and 2014. Whether the improvement is a genuine, stable turnaround or just a slight temporary easing will only become apparent in future reports. At least the downward trend observed since 2008 in terms of equal participation opportunities has halted in the majority of member states. However, even seven years after the global economic crisis first hit, participation opportunities in the vast majority of EU states – with a few exceptions – are still noticeably worse than before the crisis. Only five of the 28 EU countries – the Czech Republic, Germany, Luxembourg, the UK, and Poland – are showing moderate improvements in terms of participation opportunities, compared with the situation before the economic and financial crisis