Wiley Journal Package: UNL Download Activity by Subject

Because the field of librarianship has been reconsidering its relationship to commercial academic publishers and their \u27Big Deal\u27 journal packages, the authors decided to review the University of Nebraska-Lincoln\u27s usage of Wiley\u27s package. In this report, the authors looked into whether UNL\u27s downloads by subject were such that subscribing to a number of hypothetical smaller, subject-specific packages, rather than to the entire Wiley package, might be a viable strategy

Maksimalisasi Peran Nanoteknologi Sediaan Proniosom Dalam Sistem Penghantaran Obat Tertarget

Nanoteknologi merupakan ilmu yang berfokus pada ukuran antara 1-100 nm. Peran nanoteknologi dalam pengobatan berdasarkan pengembangan penelitian dalam biomedis sudah sampai pada nanoteknologi yang berfokus pada deteksi molekul yang terkait. Peran nanoteknologi dalam dalam pengobatan tertarget adalah kombinasi antara nanoteknologi dan biologi molekuler mengarahkan perkembangan formulasi obat menuju nanobioteknologi. Selain itu, sediaan dari nanoteknologi ini pun menjadi baru seperti proniosom. Proniosom ini asalah suatu vesikel yang terbuat dari surfaktan yang berbentuk serbuk kering maupun liquud kristalin padat yang dapat mencegah senyawa obat polar maupun nonpolar. Proniosomo secara fisik itu stabil selama penyimpanan dan transportasi dalam nanoteknologi. Metode pembuatan proniosom dilakukan dengan SEM (Scanning Elektron Microsopy), metode slurry, metode pelapisan semprotan dan metode pemisahan fase co-aservatif. Review artikel ini menyajikan bagaimana peran nanoteknologi  sediaan proniosom dalam sistem penghantaran obat yang tertarget seperti agen terapeutik, targetting group dan sistem pembawa

The Role of AI in Drug Discovery: Challenges, Opportunities, and Strategies

Artificial intelligence (AI) has the potential to revolutionize the drug discovery process, offering improved efficiency, accuracy, and speed. However, the successful application of AI is dependent on the availability of high-quality data, the addressing of ethical concerns, and the recognition of the limitations of AI-based approaches. In this article, the benefits, challenges and drawbacks of AI in this field are reviewed, and possible strategies and approaches for overcoming the present obstacles are proposed. The use of data augmentation, explainable AI, and the integration of AI with traditional experimental methods, as well as the potential advantages of AI in pharmaceutical research are also discussed. Overall, this review highlights the potential of AI in drug discovery and provides insights into the challenges and opportunities for realizing its potential in this field. Note from the human-authors: This article was created to test the ability of ChatGPT, a chatbot based on the GPT-3.5 language model, to assist human authors in writing review articles. The text generated by the AI following our instructions (see Supporting Information) was used as a starting point, and its ability to automatically generate content was evaluated. After conducting a thorough review, human authors practically rewrote the manuscript, striving to maintain a balance between the original proposal and scientific criteria. The advantages and limitations of using AI for this purpose are discussed in the last section.Comment: 11 pages, 1 figur

Research engagement for Australia: measuring research engagement between universities and end users

ATSE believes that realising the benefits of Australia’s world-class research system requires translation of its outputs into economic and societal benefits.The effective translation of research will be at the core of Australia’s future competitiveness and prosperity. Background The Australian Academy of Technological Sciences and Engineering (ATSE) advocates for a future in which technology, engineering and innovation contribute significantly to Australia’s social, economic and environmental wellbeing. The Academy is empowered in its mission by some 800 Fellows drawn from industry, academia, research institutes and government, who represent the brightest and the best in technological sciences and engineering in Australia. The Academy provides robust, independent and trusted evidence-based advice on technological issues of national importance. ATSE fosters national and international collaboration and encourages technology transfer for economic, social and environmental benefit. ATSE believes that realising the benefits of Australia’s world-class research system requires translation of its outputs into economic and societal benefits. The effective translation of research will be at the core of Australia’s future competitiveness and prosperity. Australia undertakes world-class scientific research through universities and other publicly funded research organisations, such as the Commonwealth Scientific and Industrial Research Organisation (CSIRO), the Australian Nuclear Science and Technology Organisation (ANSTO) and the Australian Institute of Marine Science (AIMS). In the Australian university sector, there are effective financial and prestige incentives that focus researchers on producing high quality publications. Excellence in Research for Australia (ERA) encourages a focus on research publication by evaluating research using indicators such as peer review and citation metrics. The Federal Government’s Department of Education and Training rewards this by allocating approximately $65 million per annum based in part on ERA outcomes through the Research Block Grants (RBG). The behaviours that ERA drives in our university sector have been even greater than might be anticipated from this small amount of funding, demonstrating that a metrics-based approach can achieve important behavioural change. While research excellence is desirable in its own right, it is not a sufficient driver of innovation and is only one dimension of the research endeavour. A focus on research excellence is often at the expense of other important activities such as university collaborations with the private and public sectors, entrepreneurial behaviour and knowledge transfer. Indeed, OECD data show that Australian universities and publicly funded research institutes and industry in Australia are less engaged in collaboration than their counterparts in other countries. This is of particular concern for Australia given around 58 per cent of our researchers are employed in the higher education sector

Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various developments to prevent and treat cancer, the side effects of anticancer drugs remain a major concern. Ascorbic acid is an essential vitamin required by our bodies for normal physiological function and also has antioxidant and anticancer activity. Although the body cannot synthesize ascorbic acid, it is abundant in nature through foods and other natural sources and also exists as a nutritional food supplement. In anticancer drug development, ascorbic acid has played an important role by inhibiting the development of cancer through various mechanisms, including scavenging reactive oxygen species (ROS), selectively producing ROS and encouraging their cytotoxicity against tumour cells, preventing glucose metabolism, serving as an epigenetic regulator, and regulating the expression of HIF in tumour cells. Several ascorbic acid analogues have been produced to date for their anticancer and antioxidant activity. The current review summarizes the mechanisms behind ascorbic acid’s antitumor activity, presents a compilation of its derivatives and their biological activity as anticancer agents, and discusses delivery systems such as liposomes, nanoparticles against cancer, and patents on ascorbic acid as anticancer agents

Classifying Australian PhD bibliographic thesis records by ANZSRC field of research codes

This report provides a brief report detailing the methods and approach used to classify the 2007-2009 theses by ANZSRC Fields of Research codes and any recommendations

Nanoemulsions as drug carriers: preclinical evaluation of pulmonary delivered drug-loaded nanocapsules

Los capítulos 3, 4 y 5 están sujetos a confidencialidad por el autor. 71 p.En esta tesis doctoral, se ha utilizado la administración pulmonar y las técnicas de imagen molecular in vivo con el objetivo final de explorar la idoneidad de polímeros y NPs poliméricas basadas en dextrano para estabilizar nanoemulsiones de aceite-en-agua cuya principal función es la encapsulación, transporte y liberación controlada de fármacos poco solubles en agua.Las nanoemulsiones resultantes se han reticulado en la interfase aceite/agua permitiendo mejorar significativamente su estabilidad a largo plazo en agua y PBS. Además, se ha estudiado su (i) capacidad de carga y (ii) liberación controlada de fármacos en presencia de enzimas de tipo lipasa, así como, (iii) su uso para prolongar el tiempo de residencia de dichos fármacos en los pulmones según lo determinado a través de tomografía por emisión de positrones (PET-CT) in vivo.Por otro lado, se ha explorado el uso del anión anfifílico conocido como COSAN, cobalto bis(dicarballuro), para la estabilización de nanoemulsiones y su capacidad para prolongar el tiempo de residencia de fármacos hidrofóbicos en los pulmones

Hybrid protein-polymer nanoparticles loaded with cisplatin: synthesis and characterization

Nowadays, many research related tovhybrid materials and the advances in Reversible-Deactivation Radical Polymerization (RDRP) techniques have enabled the development of responsive materials. These compounds respond to specific stimuli and have been integrating many research projects involving different drug delivery systems. In particular, hybrid conjugates based on protein−polymer have been integrating different formulations already approved by the Food and Drug Administration. In general, protein-polymer conjugates can increase the drug plasmatic half-life, altering the drug biodistribution profile and opening the possibility to reduce the dose administrated, which is a relevant advantage for patients. In this work, poly (N-vinylcaprolactam) (PNVCL) and poly (2-dimethylamino-ethyl methacrylate) (PDMAEMA) polymers were grafted to the surface of a protein model, the bovine serum albumin (BSA), by grafting-from approach, using the Atom Transfer Radical Polymerization (ATRP) technique. Firstly, a macroinitiator (BSA-MI) was successfully obtained and characterized by Sodium dodecyl sulfate polyacrylamide gel electrophoresis and Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry by modifying lysine groups present in the BSA. Then, the BSA-PNVCLco-PDMAEMA hybrid was synthesized using BSA-MI as an initiator. The conjugate production was evaluated, revealing significant changes in the nanoparticles’ molecular mass and zeta potential . Additionally, it is demonstrated that altering the monomers' ratio can further adjust the lower critical solution temperature (LCST) of the protein-polymer conjugates. The results indicate the obtaining of a BSA-PNVCL-coPDMAEMA able to encapsulate approximately 1.9 mg of cisplatin for each 1 mg of the hybrid, making this conjugate a very promising hybrid material with desirable properties for a possible application in smart drug delivery systems