Total Synthesis of (±)-Sorocenol B Employing Nanoparticle Catalysis
- Publication date
- 2012
- Publisher
Abstract
The total synthesis of (±)-sorocenol B has been accomplished featuring key steps including silver nanoparticle (AgNP)-catalyzed Diels–Alder cycloaddition and late-stage Pd(II)-catalyzed oxidative cyclization. The synthetic natural product exhibited low micromolar cytotoxic activity against a number of human cancer cell lines