Sequence alignment of the amino-terminal domain of the proteins <i>B. licheniformis</i> 749/I BlaR1 (BlBlaR-NTD) and <i>S. aureus</i> RN4220 BlaR1 (SaBlaR-NTD) and <i>S. aureus</i> MRSA252 MecR (SaMecR-NTD).
<p>The conserved residues are highlighted in red and the loop and transmembrane segments are marked: the transmembrane segments (TM1 to 4) in orange; the extracellular loops B1 (M<sup>1</sup>-P<sup>8</sup>) and L2 (P<sup>53</sup>-S<sup>115</sup>) in green and the cytoplasmic loops L1 (K<sup>27</sup>-T<sup>35</sup>) and L3 (Y<sup>134</sup>-K<sup>322</sup>) in blue. The site of cleavage, situated between the R<sup>293</sup> and R<sup>294</sup> in <i>S. aureus</i> BlaR1, is indicated by an arrow.</p
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