Synthesis and biological activity of trinuclear seven-coordinated tin(IV) complexes derived from tridentate ligands and trimesic acid

Abstract

<div><p>The synthesis of trinuclear Sn(IV) complexes <b>5a</b>–<b>h</b> – prepared in a one-pot reaction of 2-amino-4-R-phenol (R=H, Me, Cl, NO₂), 2-pyridine-carboxaldehyde, 1,3,5-benzenetricarboxylic acid (trimesic acid, H₃BTC), and dibutyl and dioctyltin oxides – is described. These compounds were characterized by elemental analysis, mass spectrometry, IR, and multinuclear NMR spectroscopy. The structures of <b>5a</b> and <b>5b</b> were also determined by single-crystal X-ray analysis. The trinuclear tin system is formed by bridges through the carboxylate moieties. The metal centers are seven-coordinate and the coordination polyhedron of tin can be depicted as distorted pentagonal-bipyramidal (PBP), where the equatorial plane consists of three oxygens and two nitrogens and the organic groups occupy the axial positions. The work presented here combines the useful properties of Schiff bases and H₃BTC ligands in the formation of organotin(IV) complexes, and investigates the likely antioxidant (DPPH and TBARS) and anti-inflammatory activity (TPA) of the new substances.</p></div