Magnesiation of N-Heterocycles Using i-PrMgCl · LiCl and Catalytic Diisopropylamine

Abstract

<div><p></p><p>The direct magnesiation of various N-heterocyclic compounds with i-PrMgCl · LiCl and catalytic diisopropylamine allows for preparation of 2-substituted pyrroles, imidazole, indoles, and benzimidazoles, in moderate to good yields. The magnesiated substrates canreadily undergo a Kumada-type coupling with iodo-aryls in the presence of catalytic Pd(PPh₃)₄.</p></div