The Relationship between Scoliosis Surgery and Quality of Life

Scoliosis is known as "curvature of the spine" and early diagnosis is very important. It can provide a great advantage to individuals when appropriate treatment or surgery. Today, the surgical treatment of scoliosis curvatures is very successful and an aesthetic and beautiful appearance is formed after the operation. In addition to the aesthetically beautiful appearance, the pain of individuals decreases, and their quality of life increases. This study was conducted to reveal how the quality of life of patients who had scoliosis surgery changed. The population of the study consisted of 121 patients who underwent scoliosis surgery in a private hospital in Istanbul between September 2009 and October 2010. The ages of these patients were 8 and over and 99 patients participated in the study. Data were collected with two tools, namely the information form and the Scoliosis Research Society-22 (SRS-22) scale. The independent variables of the study were demographic and disease characteristics of the cases; The dependent variable was quality of life scores. Information form and scale were applied at least 3 months after scoliosis surgery. The data were evaluated by percentage distributions, t-tests, and ANOVA analysis in a computer environment. A total of 99 patients participated in the study. Of these, 78 people were 78.8% women, and 21 people were 21.2% men. Their ages were between 8 and 20 years old. 62 people, mostly between the ages of 14-19, were 62.2%. 7 people aged at least 20 years and older were 7.1%. Mean SRS-22 and its sub-dimensions, Pain mean 21.84± 2.81, General Appearance Evaluation mean 17.66± 4.69, Spinal Function means 2 0.25± 3.64, Mental health mean 19.46± 2 The mean treatment satisfaction was found to be 9.26± 1.01, and the mean of the SRS-22 scale was 88.47± 10.68. When male and female patients were compared according to the general total mean score, the mean score of the female patients was found to be significantly higher than the mean score of the male patients. There was no difference between the groups in terms of age, education level, number of siblings, consanguineous marriage, place of residence, family type, chronic illness, and sports. The mental health sub-dimension scores of SSK patients were found to be statistically significantly higher than those of bonding and paid patients. Except for the satisfaction with the treatment sub-dimension, it was determined that the mean score of the patients with free movement was significantly higher than the mean score of the patients with partially restricted movement. The mean score of patients with scoliosis in relatives was found to be statistically significantly lower in terms of pain and spinal functions, compared to the mean score of patients whose relatives did not have scoliosis

A Study of Malaria in the Union Territory (U.T.) of Jammu and Kashmir (J & K)

Aim: To find out the status of Malaria in the U.T. of J & K. Methods: The study design included an analysis of the annual reports of the  National Centre for Vector-Borne Diseases Control (NCVBDC) pertaining to the years 2017 and 2018. Results: Rajouri District in the now newly reconstituted U. T. of J & K had the highest Annual Parasite Incidence (API) of Malaria in the U.T. of 0.12 during 2017 which decreased to 0.06 in  2018. Conclusions: If interventions like the treatment of asymptomatic carriers take place, it is expected that the API in the entire U.T. will come down sooner there

A Study of Malaria in Haryana State of India

Background: The Annual Parasite Incidence (API) of Malaria for Haryana had been observed to be decreasing from 2017 to 2018 when it reached 0.11 from 0.20. Methodology: The study design included analysis of the annual report of the Malaria Division of the National Centre for Vector-Borne Diseases Control (NCVBDC) for 2018 and a web search for information on Malaria in Haryana. Results: There is one district, Nuh, which deserves special mention because it’s API was 5.07 in 2015 which came down to 0.02 in 2020. Conclusions: Although Haryana did not reach zero Malaria cases in 2021, it did reach an API of 0.11 during 2018. Therefore, it is a good candidate for being the first state in the country close to being able to achieve near-elimination goals

Investigating the Role of Acacia Nilotica Nanoparticles on Promoting Apoptosis in Human Breast Cancer Cell Line (MDA-MB-231)

MDA-MB-231 is a model of a human breast cancer cell line. It represents a suitable cell line for breast cancer research worldwide, including anti-cancer studies. Natural products are rich in phytochemicals that have anti-cancer, antioxidant and anti-inflammatory effects. The aim of this study was to characterize the Acacia nilotica nanoparticles (AN-NPs) from the extract of Acacia nilotica (AN) using transmission electron microscopy (TEM), zeta sizer, X-ray diffraction (XRD) and Fourier transform infrared (FT-IR). Cytotoxic activity was assessed using the 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The morphological changes of the cells were examined using an inverted microscope. The results showed that at serial concentrations (5, 10, 20, 50 and 70 µg/ml) of AN extract and AN-NPs, a cytotoxic effect and morphological degeneration and damage of the cells were observed. The effect varied depending on the exposure time and AN extract and/or AN-NP concentration on MDA-MB-231. The results showed cytotoxic effects, morphological degeneration, damage and more efficacy against breast cancer cells. We can conclude that AN extract and AN-NP are an effective choice for the development of pharmacological treatments against cancer

Effects of Selenium and Zinc in Aflatoxin B1 Poisoning in Broiler

To test the effect of selenium & zinc in aflatoxin B1 poisoning in broiler, day-old broiler chicks (n=80) were divided into 5 treatment groups with 16 birds each, (T0-control; T1-50ppb AFB1 T2-100ppb AFB1, T3-200ppb AFB1, T4-400ppb AFB1), after treating  3 weeks, 8 birds were sacrificed & rest of the birds continued with AFB1 & started a new treatment with Zn & Se supplements at the dose rate Zn (40, 60, 80 mg/kgbwt) and Se (30, 40, 50 µg/kgbwt) respectively  in T2, T3 & T4  from 3rd week to 5th  week. Experiment was conducted from day 1 to 35 days of age. The broilers were weighed, bled, killed by cervical dislocation .Body weights were significantly decreased (643.66±3.17) by 400ppb aflatoxin B1 (P < 0.05) at 21 days compare to control group T0. Higher concentration aflatoxin B1 (400ppb) in T4 group significantly decreased body weight from T1 (50ppb). Aflatoxin B1 induced a significant increase biochemical parameters such as serum alanine transaminase (ALT) & aspartate transaminase (AST).Significantly elevated level (P < 0.05)  of ALT & AST were observed in T4 (58.2±0.7 & 1185±17) respectively. In case of hematological parameters, the study revealed that it also reduced the level of total erythrocyte count (TLC), total leucocyte count (TLC), hemoglobin, lymphocyte, monocyte & basophil, however it accelerated neutrophil & eosinophil level. Aflatoxin B1 raised weight of liver, spleen & diminished weight of pancreas. Higher concentration extended mortality rate upto 15% in T4 group at 3 weeks. After treating with Zn& Se, growth performances had been improved gradually, it depressed these negative effects of AFB1 in broiler. These effects of AFB1 were ameliorated by supplementation of Zn & Se. It was concluded that aflatoxin contamination (50, 100, 200, 400 ppb) in broiler diet impaired the performance in terms of body weight gain, biochemical, hematological parameter, relative organ weights & livability percentage. Supplementation of zinc & Se in the aflatoxin contaminated diet improved the adverse effects of aflatoxicosis on performance of the broiler chickens. Supplementation. In conclusion, the results demonstrated that mineral treatment (Zn & Se) might be used for correction of aflatoxin B1 in broiler

Malaria in Punjab, State of India: A Brief Overview

Background: The current status of Malaria in Punjab state of India is not known. Objectives: To find out the parameters of Malaria in Punjab state of India. Methods: By examining reports prepared by the National Center for Vector Borne Diseases Control (NCVBDC) and an internet search. Results: It was observed that the Annual Parasite Incidence (API) of Malaria in Punjab came down to low level of 0.02 in 2018 and that there were only 71 Malaria cases during 2021. Conclusions: Punjab state of India is very close to achieving Malaria-elimination goals

Annual Parasite Incidence Study of Malaria in Madhya Pradesh

The Sheopur District of Madhya Pradesh had a very high Annual Parasite Incidence (API) of Malaria during 2017 and 2018. However, if interventions like the treatment of asymptomatic carriers take place, it is expected that the API will come down soon

Reversal Processes by Dynamic Therapies: Pathophysiology, Biomarkers and Integrative Applications for Endometriosis: Case Report

Introduction: This study's goal was to understand the pathophysiology of endometriosis and its epigenetic biomarkers that are useful in proposing integrative therapies for improved health outcomes. Current conventional therapies have been ineffective in treating endometrial abnormalities observed in patients diagnosed with the disease. Patient Concerns: The endogenic treatment protocol that was based on the integrated process of reversal therapy was provided to thirty female participants enrolled in the study. Resulting fertility issues due to the disease renders a significant percentage of this population nulliparous. Literature is exhausted with research to establish relative pathogenicity of the monospecific disease as it corresponds to its molecular characteristics, symptoms, and progression. Diagnosis: Angiogenesis was found to be a characteristic mechanism during the development of endometriosis resulting from a mutation of the GnRH gene thus compromising JEG-3 cell operations. Upregulated immune-related factors and functionally prevalent angiogenesis predisposes this population to acquire abnormal endometrial outcomes. Interventions: A monotherapeutic approach was utilized consisting of a 3 part biomedical treatment protocol applied for 90 days to obtain menstral process improvements by decreasing the incidence of endometriosis and corresponding infertility. Outcomes: Proposed mechanism of action provided by The Tejeda Equation (∑(σX GnRH ⇒ JEG3f )+ (σα ^βER ) ∴ NR3A1 ≥ 300-437pg/ml e (τ +30dy)∆ δEEC) permitted development of applied biomedical treatment protocol Fig.4. The protocols therapeutic matrix addressed all aspects of Bis4 by reversal of the mutated GnRH gene, restoration of JEG-3 cells and diminished endometrial lesions Fig.1. Corresponding results proved favorably. Conclusion: Some significant genetic factors that are critical contributors to endometriosis have remained undiscovered. Continued research will be pursued that can assist in developing alternate diverse treatment strategies for the affected population

Vascular Malformation Involving the Maxillofacial Region: A Case Report

Vascular anomalies constitute some of the most difficult diagnostic and therapeutic enigmas in the head and neck region and most of the congenital vascular malformations were often misdiagnosed and left untreated. These lesions are the result of an embryonic abnormality of the vascular system. Vascular lesions in the maxillofacial region are rare. These lesions can cause facial asymmetry, loose teeth, tinnitus, headache, and bruits and can be complicated by life threatening conditions such as haemorrhage and heart failure. This article presents a case of 25-year old female patient reported to the Department of Oral Medicine and Radiology with a chief complaint of swelling on the left side of the face. Based on the clinical findings and radiological investigations such as USG with Color Doppler, MR Angiography and CBCT the case was diagnosed as slow flow venous malformation involving the left maxillofacial region. So, the present case report depicts that apart from the clinical findings advanced radiological techniques like contrast enhanced Magnetic Resonance Imaging and CBCT will acts as a useful tool for the accurate diagnosis of Vascular Anamolies (VA)

Accessory Splenic Torsion is a Rare Cause of Acute Abdomen: A Case Report and Literature Review

Background: Accessory splenic torsion is an extremely rare condition. Torsion of the accessory spleen may lead to symptoms of acute abdominal pain with accompanying nausea, vomiting, and fever. Without treatment, torsion can lead to significant complications including hemorrhagic shock, peritonitis or rupture. Case Presentation: A 47-year-old female patient was admitted to our hospital with complaints of nausea, vomiting and abdominal pain. An intra-abdominal mass was detected in the imaging findings. The patient was taken into surgery. Torsioned giant accessory spleen was detected. Splenectomy was performed and the patient was discharged at the postoperative second day. Conclusion: In cases with giant accessory spleen, prophylactic splenectomy can be considered in order to avoid possible complications such as torsion, spontaneous rupture, hemorrhage, peritonitis and intestinal obstruction