4,463 research outputs found

    Maz'ya-Shaposhnikova formula in Magnetic Fractional Orlicz-Sobolev spaces

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    In this note we prove the validity of the Maz'ya-Shaposhnikova formula in magnetic fractional Orlicz-Sobolev spaces. This complements a previous study of the limit as s↑1s \uparrow 1 performed by the second author in [21]

    Modeling Mergers of Known Galactic Systems of Binary Neutron Stars

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    We present a study of the merger of six different known galactic systems of binary neutron stars (BNS) of unequal mass with a mass ratio between 0.750.75 and 0.990.99. Specifically, these systems are J1756-2251, J0737-3039A, J1906+0746, B1534+12, J0453+1559 and B1913+16. We follow the dynamics of the merger from the late stage of the inspiral process up to ∌\sim 20 ms after the system has merged, either to form a hyper-massive neutron star (NS) or a rotating black hole (BH), using a semi-realistic equation of state (EOS), namely the seven-segment piece-wise polytropic SLy with a thermal component. For the most extreme of these systems (q=0.75q=0.75, J0453+1559), we also investigate the effects of different EOSs: APR4, H4, and MS1. Our numerical simulations are performed using only publicly available open source code such as, the Einstein Toolkit code deployed for the dynamical evolution and the LORENE code for the generation of the initial models. We show results on the gravitational wave signals, spectrogram and frequencies of the BNS after the merger and the BH properties in the two cases in which the system collapse within the simulated time.Comment: 13 pages, 10 figure

    Commentary: IL-17 in chronic inflammation: From discovery to targeting

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    A recent article titled “IL-17 in chronic inflammation: From discovery to targeting,” by Beringer et al. (2016), greatly reviewed the biology of interleukin-17 (IL-17) family members highlighting the contributions of IL-17 cytokines toward diseases and IL-17-based treatment options. Authors attractively reported how preclinical and clinical studies have provided a solid scientific justification for targeting IL-17 and/or IL-17 receptor (IL-17RA) in human diseases such as inflammatory and autoimmune disorders. Here, I wish to implement the description of the biological properties of IL-17A on the cardiovascular system, the novel underlying mechanisms on platelets aggregation, and thrombus formation, and to report the contribution of IL-17A/IL-17RA axis in the association of autoimmune diseases with cardiovascular risk

    Spectral analysis of gravitational waves from binary neutron star merger remnants

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    In this work we analyze the gravitational wave signal from hypermassive neutron stars formed after the merger of binary neutron star systems, focusing on its spectral features. The gravitational wave signals are extracted from numerical relativity simulations of models already considered by De Pietri et al. [Phys. Rev. D 93, 064047 (2016)], Maione et al. [Classical Quantum Gravity 33, 175009 (2016)], and Feo et al. [Classical Quantum Gravity 34, 034001 (2017)], and allow us to study the effect of the total baryonic mass of such systems (from 2.4M⊙2.4 M_{\odot} to 3M⊙3 M_{\odot}), the mass ratio (up to q=0.77q = 0.77), and the neutron star equation of state, both in equal and highly unequal mass binaries. We use the peaks we find in the gravitational spectrum as an independent test of already published hypotheses of their physical origin and empirical relations linking them with the characteristics of the merging neutron stars. In particular, we highlight the effects of the mass ratio, which in the past was often neglected. We also analyze the temporal evolution of the emission frequencies. Finally, we introduce a modern variant of Prony's method to analyze the gravitational wave postmerger emission as a sum of complex exponentials, trying to overcome some drawbacks of both Fourier spectra and least-squares fitting. Overall, the spectral properties of the postmerger signal observed in our simulation are in agreement with those proposed by other groups. More specifically, we find that the analysis of Bauswein and Stergioulas [Phys. Rev. D 91, 124056 (2015)] is particularly effective for binaries with very low masses or with a small mass ratio and that the mechanical toy model of Takami et al. [Phys. Rev. D 91, 064001 (2015)] provides a comprehensive and accurate description of the early stages of the postmerger.Comment: 19 pages, 6 figure

    Role of Natural Compounds in Inflammation and Inflammatory-Related Diseases

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    The papers reported here will contribute to proposing new insights into the mechanisms of several conditions, as well as suggesting new diagnostic alternatives and therapeutic targets in widespread pathologies such inflammation and inflammatory-based diseases. The discovery of the new is, as always, anchored in recourse to the old

    Choice Points:Creating Clinical Qualitative Research Studies

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    Today, more psychotherapists are seeing the utility of studying their own and others\u27 therapeutic work. With the growing popularity and acceptance of qualitative methods, the research process takes on special significance for the clinician/researcher. Using qualitative methodologies, therapists can conduct studies that are immediately relevant to their therapeutic work. In this paper, I discuss eight decisions or choice points clinician/researchers face when conducting clinical qualitative research studies. The choices I discuss are not all inclusive, yet they are representative of the choices most clinical qualitative projects required