The authors review the available data on bone tissue engineering and discuss possible new research areas that could help to make bone tissue engineering a clinical success

Allay

Anderson

Arrington

Blum

Bolander

Bouhadir

Boyne

Brown

Bruder

Cancedda

Caplan

Clemens A van Blitterswijk

Coombes

Coventry

Cowley

Damien

de Boer

de Bruijn

Dennis

Dvorak

Friedenstein

Geesink

Gert J Meijer

Goshima

Hanada

Haynesworth

Horner

James

Joost D de Bruijn

Koole

Krebsbach

Kruyt

Laflamme

Laino

Lane

Levenberg

Lind

Miura

Nefussi

Ohgushi

Oikarinen

Oklund

Pelissier

Peptan

Petite

Prolo

Puelacher

Quarto

Roberts

Robey

Ron Koole

Schalhorn

Schimming

Schliephake

Shang

Strong

Urist

van Gaalen

Wada

Warnke

Yaszemski

Yoshikawa

Yuan

PLoS Medicine

English

PubMed

Meijer, G.J.

de Bruijn, Joost Dick

Koole, R.

van Blitterswijk, Clemens

NARCIS 

Cell-based bone tissue engineering

In 6 patients the potency of bone tissue engineering to reconstruct jaw defects was tested. After a bone marrow aspirate was taken, stem cells were cultured, expanded and grown for 7 days on a bone substitute in an osteogenic culture medium to allow formation of a layer of extracellular bone matrix. At the end of the procedure, this viable bone substitute was not only re-implanted in the patient, but also simultaneously subcutaneously implanted in mice to prove its osteogenic potency. In all patients, a viable bone substitute was successfully constructed, which was proven by bone formation after subcutaneous implantation in mice (ectopic bone formation). However, the same construct was reluctant to form bone in patients with intra-oral osseous defects (orthotopic bone formation). Although biopsies, taken 4 months after reconstructing the intra-oral bone defect, showed bone formation in 3 patients, only in 1 patient bone formation was induced by the tissue-engineered construct. Although bone tissue engineering has proven its value in animal studies, extra effort is needed to make it a predictable method for reconstruction jaw defects in humans. To judge its benefit, it is important to differentiate between bone formation induced by cells from the border of the osseous defect (osteoconduction) in relation to bone matrix produced by the implanted cells (osteogenesis)

Bruijn, J.D. de

Koole, R.A.

Blitterswijk, C.A. van

Cell based bone tissue engineering in jaw defects.

Crossref

Meijer, Gert J.

Koole, Ron

University of Twente Research Information

Cell based bone tissue engineering in jaw defects

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Cell-based bone tissue engineering.

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A comparison of bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) implanted in muscle and bone of dogs at different time periods.

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Caplan A

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Comparison of osteogenic potentials of visceral and subcutaneous adipose-derived cells of rabbits.

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Pelvic instability: A consequence of removing iliac bone for grafting.

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Quantitative comparisons of healing in cranial fresh autografts, frozen autografts and processed autografts, and allografts in canine skull defects.

Regenerating the heart.

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Stimulatory effects of basic ﬁ broblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrowderived mesenchymal stem cells.

The bone inductive capacity of various bone transplanting materials used for treatment of experimental bone defects.

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The history of bone grafts.

Tissue-engineered bone for maxillary sinus augmentation.

Tissue-engineered bone regeneration.

Tissue-engineered bone repair of sheep cranial defects with autologous bone marrow stromal cells.

Use of cultivated osteoprogenitor cells to increase bone formation in segmental mandibular defects: An experimental pilot study in sheep.

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Cell-Based Bone Tissue Engineering

Cell-Based Bone Tissue Engineering

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University of Twente Research Information

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