A note on a gauge-gravity relation and functional determinants

We present a refinement of a recently found gauge-gravity relation between one-loop effective actions: on the gauge side, for a massive charged scalar in 2d dimensions in a constant maximally symmetric electromagnetic field; on the gravity side, for a massive spinor in d-dimensional (Euclidean) anti-de Sitter space. The inclusion of the dimensionally regularized volume of AdS leads to complete mapping within dimensional regularization. In even-dimensional AdS, we get a small correction to the original proposal; whereas in odd-dimensional AdS, the mapping is totally new and subtle, with the `holographic trace anomaly' playing a crucial role.Comment: 6 pages, io

Southern occupational therapies: Emerging identities, epistemologies and practices

Indexación: Web of Science; Scielo.For over a decade, debates in occupational therapy have extended into the profession's theoretical foundations as well as epistemological underpinnings thereof A series of proposals have emerged from around the world that aim to link the definition of occupational therapy, its knowledge and practices to contemporary social, political, cultural and economic conditions. Contributing to this is the increasing precariousness of the global social life, the economic crises of many social systems, and the deterioration of the ecological environment. The current paper critically reflects on the historical conditions that shape the institution of occupational therapy, particularly in the regions of South America and Africa. This involves a political, ethical, and epistemological rethinking of the foundations that underpin identities, knowledge and practices of occupational therapy and their effects on society. These foundations may favour processes of exclusion and ahistorical and individualist views of human occupation, as opposed to social perspectives expressed in collective occupations and human rights promoting practices. The authors propose to problematise the construction of a professional identity, knowledge and practices of occupational therapy, emphasising the need for a liberating discipline, committed to and acting alongside people and communities who are in situations of social exclusion. This implies the necessary positioning of occupational therapy within social transformation.http://ref.scielo.org/z57kz

Modeling field evaporation degradation of metallic surfaces by first principles calculations: A case study for Al, Au, Ag, and Pd

Indexación: Scopus.Under the effects of an extreme electric field, the atoms on a metallic surface evaporate by breaking their bonds with the surface. In this work, we present the effects of a high electric field, by the use of computational simulations, for different metallic surface chemistries: Al, Au, Ag, and Pd. To model this bond breaking procedrure (i.e. field evaporation), we use density functional theory through the Quantum-Espresso (QE) simulation package, which incorporates the electric fields by adding a saw-like funcion into the Hamiltonian. This approach, known as dipole correction, was applied to all simulations as is implemented in the QE package. In this work, we calculate the evaporation field (Fe ) for all metallic species, which corresponds to the mean field at which atoms can break their bonds from the surface and evaporate. This result is compared with experimantal data from Atom Probe Tomography (APT) and computational data from prior simulations. © Published under licence by IOP Publishing Ltd.This work was supported by the Proyecto FONDECYT Iniciación 11130501. JP Also acknowledges partial support from Proyecto FONDECYT Regular 1140514 and Proyecto UAB-775. CL acknowledges support from Proyecto FONDECYT Iniciación 11150279, Proyecto PAI-79140025, and Proyecto DI-1350-16/R.https://iopscience.iop.org/article/10.1088/1742-6596/1043/1/01203

Heme oxygenase-1 as a modulator of intestinal inflammation development and progression

Indexación: Scopus.Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO. Inflammatory Bowel Diseases, which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), are one of the most studied ailments associated to HMOX1 effects. However, microbiota imbalances and infections are also important factors influencing the occurrence of acute and chronic intestinal inflammation, where HMOX1 activity may play a major role. As part of this article we discuss the immune modulatory capacity of HMOX1 during IBD, as well during the infections and interactions with the microbiota that contribute to this inflammatory disease. © 2018 Sebastián, Salazar, Coronado-Arrázola, Schultz, Vallejos, Berkowitz, álvarez-Lobos, Riedel, Kalergis and Bueno.https://www.frontiersin.org/articles/10.3389/fimmu.2018.01956/ful

The Araucaria Project. First Cepheid Distance to the Sculptor Group Galaxy NGC 7793 from Variables discovered in a Wide-Field Imaging Survey

We have detected, for the first time, Cepheid variables in the Sculptor Group spiral galaxy NGC 7793. From wide-field images obtained in the optical V and I bands on 56 nights in 2003-2005, we have discovered 17 long-period (24-62 days) Cepheids whose periods and mean magnitudes define tight period-luminosity relations. We use the (V-I) Wesenheit index to determine a reddening-free true distance modulus to NGC 7793 of 27.68 ± 0.05 mag (internal error) ± 0.08 mag (systematic error). The comparison of the reddened distance moduli in V and I with the one derived from the Wesenheit magnitude indicates that the Cepheids in NGC 7793 are affected by an average total reddening of E(B-V)=0.08 mag, 0.06 of which is produced inside the host galaxy. As in the earlier Cepheid studies of the Araucaria Project, the reported distance is tied to an assumed LMC distance modulus of 18.50. The quoted systematic uncertainty takes into account effects like blending and possible inhomogeneous filling of the Cepheid instability strip on the derived distance. The reported distance value does not depend on the (unknown) metallicity of the Cepheids according to recent theoretical and empirical results. Our Cepheid distance is shorter, but within the errors consistent with the distance to NGC 7793 determined earlier with the TRGB and Tully-Fisher methods.The NGC 7793 distance of 3.4 Mpc is almost identical to the one our project had found from Cepheid variables for NGC 247, another spiral member of the Sculptor Group located close to NGC 7793 on the sky. Two other conspicuous spiral galaxies in the Sculptor Group, NGC 55 and NGC 300, are much nearer (1.9 Mpc), confirming the picture of a very elongated structure of the Sculptor Group in the line of sight put forward by Jerjen et al. and others

¿Existe alguna relación entre la capacidad de movimiento funcional y el estado ponderal? Un estudio en escolares españoles

Indexación: Scopus.Background: to examine relations between functional movement patterns and weight status in Spanish primary school children and to determine the differences between sexes. Methods: three hundred and thirty-three, 6-13 years old children (164 boys and 169 girls), participated in this study. The main outcome measures were the body mass index (BMI) and the Functional Movement Screen™ (FMS). Children were classified as normal weight (NW), overweight (OV) or obese (OB) according to international cut-offs. Results: total FMS score was negatively correlated with BMI (p < 0.001). FMS score was different between children from NW, OV and OB groups (p = 0.001), lower with the increased BMI (p < 0.001 between all groups). Significant differences (p < 0.05) between NW, OV and OB were found in deep squat, hurdle step, in-line lunge, shoulder mobility, straight leg-raise and push-up tests. As for the sex differences, girls obtained higher scores (p < 0.05) in in-line lunge, shoulder mobility and straight leg-raise, whereas boys did it in push-up (p = 0.044) test. Conclusions: these results confirm that total FMS score significantly and inversely correlates with BMI in a group of 333 school-age children. As for the sex differences, girls outperform boys in movements requiring flexibility and balance, whilst boys outperform girls in tests where muscular strength is required. © 2018 SENPE and Arán Ediciones S.L.Introducción: examinar la relación entre los patrones de movimiento funcional y el estado ponderal en escolares españoles, determinando también la infl uencia de la variable sexo. Métodos: trescientos treinta y tres niños de 6-13 años de edad (164 niños y 169 niñas), participaron voluntariamente en este estudio. Las variables objeto de estudio fueron el índice de masa corporal (IMC) y la batería de test Functional Movement ScreenTM (FMS). Los niños fueron clasifi cados como normopeso (NW), sobrepeso (OV) y obesos (OB) de acuerdo con los puntos de corte internacionales. Resultados: la puntuación total en el FMS correlacionó de forma negativa y signifi cativa con el IMC (p < 0,001). La puntuación en FMS fue diferente entre las categorías de peso (p = 0,001), hallando un peor rendimiento en FMS conforme aumenta el IMC (p < 0,001 entre todos los grupos). Se hallaron diferencias signifi cativas (p < 0,05) entre NW, OV y OB en los test de deep squat, hurdle step, in-line lunge, shoulder mobility, straight leg-raise and push-up. En cuanto a las diferencias por sexo, las chicas obtuvieron puntuaciones más altas en FMS (p < 0,05) en los test in-line lunge, shoulder mobility and straight leg-raise; mientras los chicos obtuvieron puntuaciones superiores en el test de push-up (p = 0,044). Conclusiones: los resultados confi rman que la puntuación total en el FMS correlaciona signifi cativa y negativamente con el IMC en este grupo de 333 escolares. En cuanto a la infl uencia del sexo, las chicas obtuvieron mayor puntuación que los chicos en los test que requerían fl exibilidad y equilibrio, mientras los chicos fueron superiores en los test en los que predominaba la fuerza muscular.https://www.nutricionhospitalaria.org/index.php/articles/01670/show#

Chocolate, Air Pollution and Children's Neuroprotection: What Cognition Tools should be at Hand to Evaluate Interventions?

Indexación: Web of ScienceMillions of children across the world are exposed to multiple sources of indoor and outdoor air pollutants, including high concentrations of fine particulate matter (PM2.5) and ozone (O-3). The established link between exposure to PM2.5, brain structural, volumetric and metabolic changes, severe cognitive deficits (1.5-2 SD from average IQ) in APOE 4 heterozygous females with >75 - <94% BMI percentiles, and the presence of Alzheimer's disease (AD) hallmarks in urban children and young adults necessitates exploration of ways to protect these individuals from the deleterious neural effects of pollution exposure. Emerging research suggests that cocoa interventions may be a viable option for neuroprotection, with evidence suggesting that early cocoa interventions could limit the risk of cognitive and developmental concerns including: endothelial dysfunction, cerebral hypoperfusion, neuroinflammation, and metabolic detrimental brain effects. Currently, however, it is not clear how early we should implement consumption of cocoa to optimize its neuroprotective effects. Moreover, we have yet to identify suitable instruments for evaluating cognitive responses to these interventions in clinically healthy children, teens, and young adults. An approach to guide the selection of cognitive tools should take into account neuropsychological markers of cognitive declines in patients with Alzheimer's neuropathology, the distinct patterns of memory impairment between early and late onset AD, and the key literature associating white matter integrity and poor memory binding performance in cases of asymptomatic familial AD. We highlight potential systemic and neural benefits of cocoa consumption. We also highlight Working Memory Capacity (WMC) and attention control tasks as opened avenues for exploration in the air pollution scenario. Exposures to air pollutants during brain development have serious brain consequences in the short and long term and reliable cognition tools should be at hand to evaluate interventions.http://journal.frontiersin.org/article/10.3389/fphar.2016.00232/ful

SinEx DB: a database for single exon coding sequences in mammalian genomes

Indexación: Web of Science.Eukaryotic genes are typically interrupted by intragenic, noncoding sequences termed introns. However, some genes lack introns in their coding sequence (CDS) and are generally known as 'single exon genes' (SEGs). In this work, a SEG is defined as a nuclear, protein-coding gene that lacks introns in its CDS. Whereas, many public databases of Eukaryotic multi-exon genes are available, there are only two specialized databases for SEGs. The present work addresses the need for a more extensive and diverse database by creating SinEx DB, a publicly available, searchable database of predicted SEGs from 10 completely sequenced mammalian genomes including human. SinEx DB houses the DNA and protein sequence information of these SEGs and includes their functional predictions (KOG) and the relative distribution of these functions within species. The information is stored in a relational database built with My SQL Server 5.1.33 and the complete dataset of SEG sequences and their functional predictions are available for downloading. SinEx DB can be interrogated by: (i) a browsable phylogenetic schema, (ii) carrying out BLAST searches to the in-house SinEx DB of SEGs and (iii) via an advanced search mode in which the database can be searched by key words and any combination of searches by species and predicted functions. SinEx DB provides a rich source of information for advancing our understanding of the evolution and function of SEGs.https://academic.oup.com/database/article-lookup/doi/10.1093/database/baw09

Expresión diferencial de genes en Pyropia columbina (Bangiales, Rhodophyta) bajo hidratación y desecación natural

Indexación: Web of Science; Scielo.RESUMEN. En Zonas Costeras rocosas, la desecación es gatillada porción Cambios Diarios en los Niveles de marea, y la Evidencia indica experimental de Me Distribución de las algas en la zona intermareal no está Relacionada estafa do palabra capacidad, párr tolerar la desecación. En Este Contexto, la Presencia de Pyropia columbina en la zona alta del intermareal sí Explica Por Su excepcional tolerancia fisiológica a la desecación. Este Estudio explora las Vías Metabólicas involucradas en la tolerancia a la desecación en P. columbina, un Través de la Caracterización de do transcriptoma Bajo Condiciones de hidratación contrastantes. Se obtuvó 1410 TER provenientes de dos Librerías de substracción de ADNc de frondas Naturalmente hidratadas y desecadas. Los transcriptomas de emba Librerías contienen transcritos de Diversas Rutas Metabólicas Relacionadas a la tolerancia. Entre el los transcritos expresados ​​15% estan involucrados en la Síntesis de Proteínas, do Procesamiento y degradacion, 14,4% Asociados un Fotosíntesis y cloroplasto, el 13,1% una mitocondrial Respiración and function, 10,6% al metabolism de la Pared Celular y 7,5% a la Actividad ANTIOXIDANTE, Proteínas chaperonas y factors de Defensa (catalasa, tiorredoxina, Proteínas de choque térmico, P450 citocromo). In Ambás Librerías sí DESTACA La Presencia De genes / Proteínas no descritos en algas. Proporciona Información This El Primer Trabajo molecular Que Estudia la tolerancia a desecación en P. columbina y Sus Resultados Ayudan a explicar los patrones clásicos de Distribución descritos párr algas en la zona intermareal. Palabras clave: Pyropia, desecación porción Estrés, EST, macroalgas, transcriptómica, Proteínas.ABSTRACT. In rocky shores, desiccation is triggered by daily tide changes, and experimental evidence suggests that local distribution of algal species across the intertidal rocky zone is related to their capacity to tolerate desiccation. In this context, the permanence of Pyropia columbina in the high intertidal rocky zone is explained by its exceptional physiological tolerance to desiccation. This study explored the metabolic pathways involved in tolerance to desiccation in the Chilean P. columbina, by characterizing its transcriptome under contrasting conditions of hydration. We obtained 1,410 ESTs from two subtracted cDNA libraries in naturally hydrated and desiccated fronds. Results indicate that transcriptome from both libraries contain transcripts from diverse metabolic pathways related to tolerance. Among the transcripts differentially expressed, 15% appears involved in protein synthesis, processing and degradation, 14.4% are related to photosynthesis and chloroplast, 13.1% to respiration and mitochondrial function (NADH dehydrogenase and cytochrome c oxidase proteins), 10.6% to cell wall metabolism, and 7.5% are involved in antioxidant activity, chaperone and defense factors (catalase, thioredoxin, heat shock proteins, cytochrome P450). Both libraries highlight the presence of genes/proteins never described before in algae. This information provides the first molecular work regarding desiccation tolerance in P. columbina, and helps, to some extent, explaining the classical patterns of ecological distribution described for algae across the intertidal zone.http://ref.scielo.org/jm5rc

Conserved quantities for a charged rotating black holes in 5D Einstein-Maxwell-Chern-Simons theory

Indexación: Scopus.In this work, we compute the conserved quantities of a charged rotating black hole which appears as the solution of Einstein-Maxwell action in five dimensions coupled to a Chern-Simons term for U(1) field. The addition of the Chern-Simons term will modify the Maxwell equations and the definition of charge but not the Einstein field equations. Upon the addition of suitable boundary terms for the pure gravity sector of the theory, which depend on the extrinsic and intrinsic curvatures (Kounterterms), we obtain the correct conserved quantities of the solution. © Published under licence by IOP Publishing Ltd.We thank Giorgos Anastasiou and David Rivera-Betancour for insightful discussions. This work was funded in part by FONDECYT Grant 1131075, UNAB Grant DI-1336-16/RG and CONICYT Grant DPI 20140115.https://iopscience.iop.org/article/10.1088/1742-6596/1043/1/01202