815,021 research outputs found
Arterial oxygen content is precisely maintained by graded erythrocytotic responses in settings of high/normal serum iron levels, and predicts exercise capacity: an observational study of hypoxaemic patients with pulmonary arteriovenous malformations.
Oxygen, haemoglobin and cardiac output are integrated components of oxygen transport: each gram of haemoglobin transports 1.34 mls of oxygen in the blood. Low arterial partial pressure of oxygen (PaO2), and haemoglobin saturation (SaO2), are the indices used in clinical assessments, and usually result from low inspired oxygen concentrations, or alveolar/airways disease. Our objective was to examine low blood oxygen/haemoglobin relationships in chronically compensated states without concurrent hypoxic pulmonary vasoreactivity.165 consecutive unselected patients with pulmonary arteriovenous malformations were studied, in 98 cases, pre/post embolisation treatment. 159 (96%) had hereditary haemorrhagic telangiectasia. Arterial oxygen content was calculated by SaO2 x haemoglobin x 1.34/100.There was wide variation in SaO2 on air (78.5-99, median 95)% but due to secondary erythrocytosis and resultant polycythaemia, SaO2 explained only 0.1% of the variance in arterial oxygen content per unit blood volume. Secondary erythrocytosis was achievable with low iron stores, but only if serum iron was high-normal: Low serum iron levels were associated with reduced haemoglobin per erythrocyte, and overall arterial oxygen content was lower in iron deficient patients (median 16.0 [IQR 14.9, 17.4]mls/dL compared to 18.8 [IQR 17.4, 20.1]mls/dL, p<0.0001). Exercise tolerance appeared unrelated to SaO2 but was significantly worse in patients with lower oxygen content (p<0.0001). A pre-defined athletic group had higher Hb:SaO2 and serum iron:ferritin ratios than non-athletes with normal exercise capacity. PAVM embolisation increased SaO2, but arterial oxygen content was precisely restored by a subsequent fall in haemoglobin: 86 (87.8%) patients reported no change in exercise tolerance at post-embolisation follow-up.Haemoglobin and oxygen measurements in isolation do not indicate the more physiologically relevant oxygen content per unit blood volume. This can be maintained for SaO2 ≥78.5%, and resets to the same arterial oxygen content after correction of hypoxaemia. Serum iron concentrations, not ferritin, seem to predict more successful polycythaemic responses
Preparation and Characterization of Homogeneous YBCO Single Crystals with Doping Level near the SC-AFM Boundary
High-purity and homogeneous YBa2Cu3Oy single crystals with carrier doping
level near the AFM-SC boundary have been obtained in the oxygen content range
between y = 6.340 and 6.370. The crystals are ortho-II phase at room
temperature and undergo the orthorhombic to tetragonal transition at about
140_Degree_C. They show sharp superconducting transitions, with Tc between 4
and 20 K. Tc changes by 0.8 K when the oxygen content y is changed by 0.001,
and is also sensitive to annealing conditions near room temperature, due to the
dependence of doping on oxygen ordering correlation lengths. Crystals with
oxygen content y lower than 6.345 are non-superconducting.Comment: 6 page
A Study of Magnetic Properties of Solid Oxygen, Oxygen-Argon and Oxygen-Fluorine
To acquire information on the interaction between oxygen molecules in solid phase, studies have been carried out on the magnetic properties of solid oxygen, oxygen-argon and oxygen-fluorine. Review of the studies on the interaction between oxygen molecules is cited. Magnetic susceptibility was measured by the Faraday method as a function of temperature from 12 K to the melting point of them. Pure oxygen both in α and β phase indicates paramagnetism corresponding to long-range antiferromagnetic order. Oxygen -argon mixtures of 92~66 mol% oxygen content indicate large susceptibility corresponding to δ phase, which can be interpreted in terms of the cluster of oxygen molecules in trimer. Small paramagnetism was found for the oxygenfluorine mixture even as dilute as 10 mol% oxygen
content, which may be due to the strong antiferromagnetic
interaction. This can be interpreted in terms of super-exchange interaction between oxygen molecules via fluorine molecule
The effects on arterial haemoglobin oxygen saturation and on shunt of increasing cardiac output with dopamine or dobutamine during one-lung ventilation
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsTheoretically, if the cardiac output were increased in the presence of a given intrapulmonary shunt, the arterial saturation should improve as the venous oxygen extraction per ml of blood decreases if the total oxygen consumption remains constant. Previous work demonstrated that this was not achieved with adrenaline or isoprenaline as increased shunting negated any benefit from improved cardiac output and mixed venous oxygen content. However, pharmacological stimulation of cardiac output and venous oxygen without any increase in shunt should achieve the goal of improved arterial oxygenation. To test this hypothesis, seven pigs were subjected to one-lung ventilation and infused on separate occasions, with dopamine and with dobutamine in random order to increase the cardiac output. The mixed venous oxygen content, shunt fraction, oxygen consumption and arterial oxygen saturation were measured. With both dopamine and dobutamine there was a consistent rise in venous oxygen content. However, with dopamine, the mean shunt rose from 28% to 42% and with dobutamine, the mean shunt rose from 45% to 59% (both changes P<0.01). With dopamine, the mean arterial oxygen saturation fell by 4.7%, and with dobutamine by 2.9%, but neither fall was statistically significant. It is concluded that any benefit to arterial saturation which might occur from a dopamine- or dobutamine-induced increase in mixed venous oxygen content during one-lung ventilation is offset by increased shunting. During one-lung anaesthesia, there would appear to be no benefit to arterial saturation in increasing cardiac output with an infusion of either dopamine or dobutamine.W. J. Russell, M. F. Jameshttp://www.aaic.net.au/Article.asp?D=200331
Oxygen non-stoichiometry in Ru-1212 and Ru-1222 magnetosuperconductors
Here we report the results of thermogravimetric (TG) analysis on the oxygen
non-stoichiometry of RuSr2GdCu2O8 (Ru-1212) and
RuSr2(Gd0.75Ce0.25)2Cu2O10(Ru-1222) samples. With TG annealings carried out in
O2 and Ar atmospheres it was found that the oxygen content in Ru-1212 remains
less affected upon various annealings, while for Ru-1222 wider-range
oxygen-content tuning is possible. When heated in H2/Ar atmosphere the both
phases release oxygen upon breaking down to mixtures of metals (Ru and Cu) and
binary oxides (CeO2, Gd2O3, and SrO) in two distinct steps around 300 and 450
oC. This reductive decomposition reaction carried out in a thermobalance was
utilized in precise oxygen content determination for these phases. It was found
that the 100-atm O2-annealed Ru-1212 sample was nearly stoichiometric, while
the similarly treated Ru-1222 sample was clearly oxygen deficient. X-ray
absorption near-edge (XANES) spectroscopy was applied to estimate the valence
of Ru in the samples. In spite of the fact that the Ru-1212 phase was shown to
possess less oxygen-deficient RuO2 layer, the valence of Ru as probed with
XANES was found to be lower in Ru-1212 than that in Ru-1222.Comment: 11 pages text, 4 pages Figs. To ISS 2002 YOKOHAMA for PHYSICA
Ultimate intrinsic-coercivity samarium-cobalt magnet: An Earth-based feasibility study for space-shuttle missions
Techniques for containerless melting and solidification of the samarium-cobalt alloy without excessive oxidation were developed. The rationale for extending these experiments in a weightless environment is also discussed. The effect of oxygen content from 0.15 to 0.63 weight percent and grain size in the range of 2 to 10 micrometers has been examined on arc-plasma-sprayed SmCo5 magnets. Contrary to expectations, the larger grain sizes tended to improve the coercivities. This was attributed to an increase in homogeneity resulting from higher temperature treatments used to produce larger grain size. No significant differences in coercivity were observed on the basis of oxygen content in the range examined. It is expected that more meaningful data on the relationship between oxygen content and coercivity will be seen when the oxygen content can be lowered to less than 0.1 weight percent
Theoretical analysis of oxygen vacancies in layered sodium cobaltate Na_xCoO_{2-\delta}
Sodium cobaltate with high Na content is a promising thermoelectric material.
It has recently been reported that oxygen vacancies can alter the material
properties, reducing its figure of merit. However, experimental data concerning
the oxygen stoichiometry are contradictory. We therefore studied the formation
of oxygen vacancies in Na_xCoO_2 with first principles calculations, focusing
on x = 0.75. We show that a very low oxygen vacancy concentration is expected
at the temperatures and partial pressures relevant for applications.Comment: 4 page
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