Sexual dysfunction in subjects treated with inhibitors of 5a-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis

Sexual dysfunction in subjects treated with inhibitors of 5a-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysi

Report on the results of the tree-rings meta-analysis

This manuscript summarises the work done during the first 6 months of the Medit Project, dealing in particular with the tree-rings database developed and analysed within component C1 (“Literature Review and Metadata Collection”). This report summarises the development and analysis of the tree-rings database. An accompanying report (Deliverable No2) summarises the functional traits dataset development and meta-analysi

Consistency between direct trial evidence and Bayesian Mixed Treatment Comparison: Is head-to-head evidence always more reliable?

Objectives: This study aims to highlight the benefits of Bayesian mixed treatment comparison (MTC), within a case study of the efficacy of three treatments (pegfilgrastim, filgrastim and lenograstim) for the prevention of febrile neutropenia (FN) following chemotherapy. Methods: Two published meta-analyses have assessed the relative efficacy of the three treatments based on head-to-head trials. In the present study, all the trials from these meta-analyses were synthesised within a single network in a Bayesian MTC. Following a systematic review, the evidence base was then updated to include further recently-published trials. The metaanalyses and MTC were re-analysed using the updated evidence base. Results: Using data from the previously-published meta-analyses only, the relative risk of FN for pegfilgrastim vs. no treatment was estimated at 0.08 (95% confidence interval: 0.03, 0.18) from the head-to-head trial and 0.27 (95% credible interval: 0.12, 0.60) from the MTC, reflecting strong inconsistency between the results of the direct and indirect methodologies. When subsequently-published head-to-head trials were included, the meta-analysis estimate increased to 0.29 (95% confidence interval: 0.15, 0.55), while the MTC gave a relative risk of 0.34 (95% credible interval: 0.23, 0.54). The initial MTC results were therefore a better predictor of subsequent study results than was the direct trial. The MTC was also able to estimate the probability that there were clinically significant difference in efficacy between the treatments. Conclusions: Bayesian MTC provides clinically relevant information, including a measure of the consistency of direct and indirect evidence. Where inconsistency exists, it should not always be assumed that the direct evidence is more appropriate

The Effect of the Violence Types Encountered by Emergency Nurses on their Burnout Levels: A Systematic Review and Meta-Analysis

The Effect of the Violence Types Encountered by Emergency Nurses on their Burnout Levels: A Systematic Review and Meta-Analysi

Mere exposure effects - Merely total activation?

The mere exposure effect, in which subjects prefer items they have previously been exposed to over unexposed items, is explained as the effect of competitive learning in a connectionist network. This type of unsupervised learning will cause the network to respond more strongly to patterns on which it has been trained. If it is assumed that positive affect is proportional to total activation, then the mere exposure effect is a direct consequence of this process. The addition of a habituation rule, with a dishabituating recovery element, can also explain factors which reduce or enhance the effect. These include the effect of exposure count, display presentation sequence, the complexity of the patterns, the effect of a delay after presentation, and finally, the effects of varying exposure duration. In the case of this last factor, in addition to showing that very short exposure durations can enhance the effect, the model reveals why it may be possible to respond positively to a stimulus that one cannot recall perceiving

Application of Werthner and Klein’s Model in Tourism Context

Web evaluation has become a critical process in DMOs’ performance measurement efforts.  However, Web evaluation research over the past decade has led to diverse approaches and findings rather than a unified understanding of success factors that should be measured in order to gauge a Web site’s performance.  The common success factors and potential additional factors identified in this study provide an important basis for practical Web evaluation implementation and simultaneously serve as a useful input for future research.  The major benefit of this study is the digest of a large volume of key factors into one comprehensive model that can be tested and applied to Web site development and evaluation problems.  This integration helps to identify not only commonalities but also gaps in existing approaches. Keywords: Destination marketing; DMOs’ performance measurement; E-satisfaction; E-loyalty; E-quality; Qualitative meta-analysi

Varian Pahang dan Kalimantan Brugia malayi subperiodik nokturnal (Nematoda: Filarioidea) penyebab filariasis

Cr Siti Utari - Varian Pahang dan Kalimantan Brugia malayi subperiodik nokturnal (Namatoda:Filarioldeal penyebab filariasis Latar belakang: B.malayi subperiodik nokturnal dijumpai sebagai masalah kesehatan, baik di Pahang Timur, Semenanjung, Malaysia Barat maupun di Kakap, Kalimantan Barat, Indonesia. Cacing filaria itu ditularkan oleh nyamuk yang sama, yaitu Mansonia uniformis sebagai vektor utamanya. Tujuan: mengetahui perbedaan pola perilaku mikrofilaria dalam darah tepi di kedua Pahang Timur dan Kalimantan Barat dengan meta analisis statistik pada data yang ada yang telah dipublikasi oleh peneliti terdahulu. Metodologi: menggunakan formula Aikat dan Das untuk meta-analisis. Hasil: mikrofilaria B.malayi masih cenderung ke arah nonperiodik di Pahang Timur dan telah ke arah periodik nokturnal di Kalimantan Barat. Simpulan: B.malayi subperiodik nokturnal menunjukkan sebagai varian (subsub-spesies) yang berbeda.di Pahang Timur, Malaysia dan Kalimantan Barat, Indonesia. Key words: B. Malaya\u27s microfilaria - nonturnally subperiodic - nocturnally periodic - nonperiodic - meta analysi