Nonuniform Bessel-Based Radiation Distributions on A Spherically Curved Boundary for Modeling the Acoustic Field of Focused Ultrasound Transducers

Therapeutic focused ultrasound is a technique that can be used with different intensities depending on the application. For instance, low intensities are required in nonthermal therapies, such as drug delivering, gene therapy, etc.; high intensity ultrasound is used for either thermal therapy or instantaneous tissue destruction, for example, in oncologic therapy with hyperthermia and tumor ablation. When an adequate therapy planning is desired, the acoustic field models of curve radiators should be improved in terms of simplicity and congruence at the prefocal zone. Traditional ideal models using uniform vibration distributions usually do not produce adequate results for clamped unbacked curved radiators. In this paper, it is proposed the use of a Bessel-based nonuniform radiation distribution at the surface of a curved radiator to model the field produced by real focused transducers. This proposal is based on the observed complex vibration of curved transducers modified by Lamb waves, which have a non-negligible effect in the acoustic field. The use of Bessel-based functions to approximate the measured vibration instead of using plain measurements simplifies the rationale and expands the applicability of this modeling approach, for example, when the determination of the effects of ultrasound in tissues is required.This research was funded by CONACyT, grant number 257966; CSIC, grant number COOPB20166; ERAnet-EMHE CSIC, grant number 200022; Spanish P.N RETOS, grant number DPI2017-90147-R; and CYTED-Ditecrod Network Ref. 218RT0545.We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)Peer reviewe