3 research outputs found
Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs
Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require
complicated revision procedures that are troublesome to patients and costly to the healthcare system.
Innovative approaches to tackle infections are urgently needed. We investigated the histological
response of novel free P2O5 glass-ceramic rods implanted in the jaws of beagle dogs. Due to the
particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body
environment and the immature bone formation during the fourth months of implantation maintained
the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle
dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent
bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue
engineeringThis work was supported by the Spanish Ministry of Science and Innovation (MICINN) under the projects
MAT2012-38645. A.P. Tomsia work was supported by the National Institutes of Health/National Institute of
Dental and Craniofacial Research (NIH/NIDCR) Grant No. 1R01DE015633S
Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs
Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P 2 O 5 glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering.This work was supported by the Spanish Ministry of Science and Innovation (MICINN) under the projects MAT2012-38645. A.P. Tomsia work was supported by the National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) Grant No. 1R01DE015633.Peer Reviewe