Government and industry

Performance, cost, and time factors in nasa programs and contract

Apollo 204 Review Board activities Second interim report

Accident investigation of Apollo spacecraf

Apollo 204 Review Board meetings Third interim report

Interim report of Apollo 204 Review Boar

A novel neural prediction error found in anterior cingulate cortex ensembles

The function of the anterior cingulate cortex (ACC) remains controversial, yet many theories suggest a role in behavioral adaptation, partly because a robust event-related potential, the feedback-related negativity (FN), is evoked over the ACC whenever expectations are violated. We recorded from the ACC as rats performed a task identical to one that reliably evokes an FN in humans. A subset of neurons was found that encoded expected outcomes as abstract outcome representations. The degree to which a reward/non-reward outcome representation emerged during a trial depended on the history of outcomes that preceded it. A prediction error was generated on incongruent trials as the ensembles shifted from representing the expected to the actual outcome, at the same time point we have previously reported an FN in the local field potential. The results describe a novel mode of prediction error signaling by ACC neurons that is associated with the generation of an FN

Occupational therapy and multiple sclerosis a study to determine use and perceived need of services

The purposes of this study were to determine the number of PwMS (people with multiple sclerosis) across the lifespan, in the United States, and within a given sample who use occupational therapy (OT) services, to determine the perceived need for OT services among PwMS, and to determine reasons why PwMS might not use OT services including the effect of quality of life. Forty-five PwMS responded to an anonymous, researcher designed survey either online or through the mail. The majority of PwMS who responded to the survey were not using OT services as a part of their treatment for MS for reasons including a lack of knowledge of OT, limited or no health insurance coverage, and lack of referral for OT treatment. Many PwMS who have used OT in the past as a part of their treatment for MS felt that OT was helpful for them. The results of the study suggest there is a marketing dilemma for the profession of occupational therapy. There is a strong need for occupational therapists to market, promote, and advocate for the profession of OT to PwMS and to members of MS treatment teams

Integrating emerging trends in upstream process development: Autosampling, nutrient feedback control, and single use tanks

Key to effective upstream development is the presence of resource-efficient systems for examining complex process options. In this presentation, we report the design and characterization of a 3-L rigid single-use bioreactor (SUB), combined with a completely automated sampling and control system capable of evaluating different metabolic-based feed strategies. Considerations in our development of a custom 3-L SUB, targeted to replace current workhorse glass reactors, encompassed proper technical functionality to flexibility and ease of use. Highlights include: vessel configuration details (impeller, sparger, baffles), perfusion readiness, agitation system design (magnetic bottom drive), and extra sensor ports and feed lines. The SUB was developed through multiple iterations to arrive at the final design, which was characterized experimentally for kLa and by CFD for mixing. The final engineering design is able to support cell density above 100x106 cells/mL. In parallel we pursued an automated system capable of investigating feed strategies tailored to real-time cell metabolite measurements, i.e. with feedback control based upon residual metabolite levels. In the end our customized automated sampling and feed control system allows programmed sampling of both cell-free and cell-containing retains from eight bioreactors, delivery to integrated analyzers, and control of nutrient feed pumps (2 per bioreactor). The system is capable of feedback control to implement individualized feed strategies that incorporate data inputs from the integrated analyzers. Implementation of the custom 3-L SUBs and automated sampling and feed control system has enabled enhanced process development capability, by introducing technology to both improve operational efficiency and facilitate experiments of greater complexit