5,269 research outputs found

    Estimating crack tip position in adhesively bonded joints subjected to mode II quasi‐static loading

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    This study aimed at estimating crack tip position in adhesive bonded joints under mode II quasi-static loading using experimental and numerical approaches. Experimental techniques were utilized and compared, including optical backscatter reflectometry, visual testing, and a novel strategy based on digital image correlation. Additionally, a finite element analysis was employed to identify the numerical crack tip position and the extent of damage within the bondline. This analysis revealed that a significant portion of the crack propagation region in the adhesive is occupied by the fracture process zone. Moreover, optical backscatter reflectometry shows the potential to detect this process zone within the adhesive that the other methods may not detect. This capability is particularly beneficial for detecting damage at early stages.OBR and DIC were used for crack initiation and propagation in ENF joint under mode II.OBR back-face strain demonstrated its ability to detect potential early-stage damage.Trapezoidal TSL outperformed bi-linear TSL in FE crack propagation modeling.A significant portion of crack propagation region was occupied by FPZ in adhesive

    Prevalence of Spinal Muscular Atrophy in the Era of Disease-Modifying Therapies: An Italian Nationwide Survey

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    ObjectiveSpinal muscular atrophy (SMA) is a neurodegenerative disorder caused by mutations in the SMN1 gene. The aim of this study was to assess the prevalence of SMA and treatment prescription in Italy.MethodsAn online survey was distributed to 36 centers identified by the Italian government as referral centers for SMA. Data on the number of patients with SMA subdivided according to age, type, SMN2 copy number, and treatment were collected.ResultsOne thousand two hundred fifty-five patients with SMA are currently followed in the Italian centers with an estimated prevalence of 2.12/100,000. Of the 1,255, 284 were type I, 470 type II, 467 type III, and 15 type IV with estimated prevalence of 0.48, 0.79, 0.79 and 0.02/100,000, respectively. Three patients with SMA 0 and 16 presymptomatic patients were also included. Approximately 85% were receiving one of the available treatments. The percentage of treated patients decreased with decreasing severity (SMA I: 95.77%, SMA II: 85.11%, SMA III: 79.01%).DiscussionThe results provide for the first time an estimate of the prevalence of SMA at the national level and the current distribution of patients treated with the available therapeutical options. These data provide a baseline to assess future changes in relation to the evolving therapeutical scenario

    Cervical pessary for preterm birth prevention after an episode of arrested preterm labor: a retrospective cohort study with targeted maximum likelihood estimation of the average treatment effect

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    OBJECTIVE: To evaluate whether cervical pessary effectively reduces the preterm birth 30.1 gestational weeks. CONCLUSIONS: The positioning of a cervical pessary placement may be evaluated to reduce the risk of a subsequent preterm birth after an episode of arrested preterm labor in pregnant patients with onset of symptoms before 30 gestational weeks