DNA repair, DNA replication and human disorders: A personal journey

I was born in 1946 and grew up in the industrial north-west of England close to the city of Manchester. My parents were German- Jewish refugees, who left Germany fairly early, in 1933. My father helped to establish and was one of the directors of a tannery, which made leather for shoes and handbags. This was part of a group of tanneries established first in Strasbourg by my great-grandfather Ferdinand Oppenheimer. I would describe my childhood and adolescent years as comfortable by general post-war standards. I went to a state primary school and obtained a scholarship to Manchester Grammar School (MGS), a fairly prestigious secondary school. As a child I was always interested in chemistry but had little interest in or knowledge of biology. The educational system in the UK at that time was such that one had to specialise very early and as a consequence I have had no formal biology education since the age of 12, something I have managed to hide reasonably successfully for the rest of my life! In my final two years at MGS I studied just physics, chemistry and mathematics and obtained a scholarship to Pembroke College, Cambridge (England) to study Natural Sciences, with the intention of becoming a chemist. In the second year at Cambridge, one of the options was a course on biochemistry. Having no real idea what this was, I read a book about it in the summer of 1965, and was truly astonished and excited to discover that the basis of life was just a bunch of rather complicated organic chemistry reactions. So I took the biochemistry course in my second year. By the end of that year, I was fed up with chemistry and for my final year I chose to do biochemistry rather than chemistry, a decision I have not regretted. The biochemistry lectures must have been pretty up-to-date, as we were told briefly about the discovery of DNA repair by Dick Setlow [1], a topic that seemed rather esoteric at the time

A presentation of Quantum Logic based on an "and then" connective

When a physicist performs a quantic measurement, new information about the system at hand is gathered. This paper studies the logical properties of how this new information is combined with previous information. It presents Quantum Logic as a propositional logic under two connectives: negation and the "and then" operation that combines old and new information. The "and then" connective is neither commutative nor associative. Many properties of this logic are exhibited, and some small elegant subset is shown to imply all the properties considered. No independence or completeness result is claimed. Classical physical systems are exactly characterized by the commutativity, the associativity, or the monotonicity of the "and then" connective. Entailment is defined in this logic and can be proved to be a partial order. In orthomodular lattices, the operation proposed by Finch (1969) satisfies all the properties studied in this paper. All properties satisfied by Finch's operation in modular lattices are valid in Hilbert Space Quantum Logic. It is not known whether all properties of Hilbert Space Quantum Logic are satisfied by Finch's operation in modular lattices. Non-commutative, non-associative algebraic structures generalizing Boolean algebras are defined, ideals are characterized and a homomorphism theorem is proved.Comment: 28 pages. Submitte

An Apparent Order of Sensory Ability Changes in Human Beings \ud

Examination of records and personal documents of 1309 human beings isolated an apparent order of sensory ability changes, for 154 members of the sample both records and personal documents were available. The five changes in the apparent order are (a) an improvement in auditory perception that always includes an increase in complexity of speech, (b) an improvement in ability to taste or to smell or both and comparative myopia in which the developing human being becomes more near-sighted than he or she has been, (c) an increase in ability to discern and separate aural or visual or aural and visual stimuli simultaneously received, (d) comparative hyperopia, and (e) a marked increase in ability in one or more up to all five of the sensory abilities considered in the research: audition, vision, gustation, olfaction, and touch. Truncation of movement through the order is a salient feature, and the fourth change, comparative hyperopia, may be skipped. If the apparent order is significant and supportable, it may lead to new, productive research in many affected disciplines

Pre-packaged fresh fish - Searching for quality descriptive criteria

32 Proben verpackten Frischfischs in Selbstbedienungspackungen, 16 Seelachs- und 16 Rotbarschproben aus deutschen Supermärkten wurden mit physikalischen, chemischen, mikrobiellen und sensorischen Methoden untersucht. Ziel der Untersuchung war dieWertung von Untersuchungsmethoden zur Qualitätsbestimmung. Es zeigte sich, daß neben der sensorischen Beurteilung die Bestimmung des TVB-N geeignet ist, die Qualität dieser Produkte zu beurteilen

Speech transcription using MED

MED (Media EDitor) is a program designed to facilitate the transcription of digitized soundfiles into textfiles. It was written by Hans Drexler and Daan Broeder, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. [...] The aim of MED is to facilitate the transcription of sound into text using a single program. It works on the principle of the coexistence and interaction of two basic elements, the waveform display window and the text window. [...] This means that you no longer need to use both a sound editor and a word processor at the same time in order to transcribe digitized speech files. Instead, you can directly type the sound you hear (and see) via MED into the text window. Furthermore, you can directly link sound portions of the waveform display window to text portions of the text window, so that you can easily locate and listen to the original source of your transcription once the links have been set. In this function the waveform display window and the text window virtually interact with each other