349 research outputs found

    A Survey of Foreign Students’ Cross-cultural Adaptation in Chongqing Normal University—A Case Study of Sri Lankan Students

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    Cross-cultural adaptation research is an important part of study for foreign students. With theories of Searle & Ward and John W. Berry, mainly from two aspects: psychological adaptation and social-cultural adaptation, the research investigates Sri Lankan students’ cross-cultural adaptation in Chongqing Normal University and analyzes the problems of Sri Lankan students’ cross-cultural adaptation in Chongqing Normal University in four aspects: Chinese reading and vocabulary, communication and exchange, adaptation of learning and teaching styles and knowledge of Chinese culture. Combined with the survey and problems of Sri Lankan students’ adaptation, the research will be used to give relevant suggestions to help Sri Lankan students adapt Chinese culture better

    Ground Filtering Algorithms for Airborne LiDAR Data: A Review of Critical Issues

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    This paper reviews LiDAR ground filtering algorithms used in the process of creating Digital Elevation Models. We discuss critical issues for the development and application of LiDAR ground filtering algorithms, including filtering procedures for different feature types, and criteria for study site selection, accuracy assessment, and algorithm classification. This review highlights three feature types for which current ground filtering algorithms are suboptimal, and which can be improved upon in future studies: surfaces with rough terrain or discontinuous slope, dense forest areas that laser beams cannot penetrate, and regions with low vegetation that is often ignored by ground filters

    CSR についての序説的一考察

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    The market mechanism seeking a globally efficient economy continues to develop. On the other hand, problems such as greenhouse effect gas emission, the disparity between regions or between persons, massive unemployment, and encroachment of human right, are taking on critical dimensions. In order to resolve these problems, enterprises have to be the entities contributing to society. Here lies the nexus for contact between CSR (Corporate Social Responsibility) and society. This article views the transformation of the concept of CSR in the process of changes in the relationship between enterprises and society. This is preceded by a brief presentation of CSR based on the economic thought of Karl Polanyi. Finally, this paper suggests the problems CSR needs to tackle in this century

    BOP ビジネスについての一考察

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    There are a variety of social problems that obstruct successful business activity. One example is the recurrences of terrorism with its most obvious cause being poverty. It is estimated that at present about 4 billion people belong to the world\u27s lowest economic strata. This large stratum of poverty has paralyzed markets in developing countries to a standstill, making them incapable of finding a way to progress out of stagnation and acquire sustainable growth. Recently, attention has gathered towards new business models that see business chances existing in social problems and the realization of innovative enterprises that result in solutions.This is called "Base of the Pyramid" or BOP business. Here I describe the potential of BOP business from the point of view of social innovation

    CSR と経営戦略 : 戦略的競争優位を求めて

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    The enterprises recently tend to incorporate the concept of the corporate social responsibility into their business strategy more and more. Accordingly, the CSR is considered as an important one of the factors in business strategy. First, we review the transition of the concept of the business strategy on the study of Hofer and Schendel. We present the theory of Michel Porter which forms the mainstream of the theory of the competitive advantage in the second chapter and finally, clarify his new theory of the competitive advantage which incorporates the concept of the CSR and examines the influences of the CSR on the business strategy of the enterprise

    ソーシャル・イノベーションとソーシャル・エンタープライズ : CSR の拡充に向けての伏線

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    We have a variety of the social problems like the poverty, the human right, environmental problems and so on, especially after 1990\u27s. But they identify that the central government or the municipality at fiscal risk don\u27t have the capability enough to respond to such social problems. Therefore, the enterprises which detect the solution of such social problems in their business recently emerge. We call them the social enterprise. We examine the movements and the development of the social enterprise in this article

    A Hybrid Model Based on Support Vector Machine for Bus Travel-Time Prediction

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    Effective bus travel time prediction is essential in transit operation system. An improved support vector machine (SVM) is applied in this paper to predict bus travel time and then the efficiency of the improved SVM is checked. The improved SVM is the combination of traditional SVM, Grubbs’ test method and an adaptive algorithm for bus travel-time prediction. Since error data exists in the collected data, Grubbs’ test method is used for removing outliers from input data before applying the traditional SVM model. Besides, to decrease the influence of the historical data in different stages on the forecast result of the traditional SVM, an adaptive algorithm is adopted to dynamically decrease the forecast error. Finally, the proposed approach is tested with the data of No. 232 bus route in Shenyang. The results show that the improved SVM has good prediction accuracy and practicality

    Cell cycle-dependent phosphorylation of nucleophosmin and its potential regulation by peptidyl-prolyl cis/trans isomerase

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    Nucleophosmin (NPM) is a ubiquitously expressed phosphoprotein involved in many cellular processes. Phosphorylation is considered the major regulatory mechanism of the NPM protein, associated with diverse cellular events. In this study, we characterized the phosphorylation status of several physiological phosphorylation sites of NPM, especially the newly confirmed in vivo site threonine 95 (Thr95). NPM-Thr95 exhibits a transient and cell cycle-dependent phosphorylation state compared to several other in vivo phosphorylation sites examined, including Ser4, Thr199 and Thr234/Thr237. In addition, we characterized a functional interaction between NPM and the peptidyl-prolyl isomerase Pin1, which specifically bind to each other during mitosis. The demonstration of this binding represents a novel post-phosphorylation regulatory mechanism for NPM that has not been investigated before. Mutated Pin1 putative binding sites result in defected cell division and reduced number of mitotic cells, suggesting that post-phosphorylation is important for NPM in regulating cell cycle progression

    Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice

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    <p>Abstract</p> <p>Background</p> <p>Treatment failure after radiotherapy of head and neck squamous cell carcinoma (HNSCC) could be a significant problem. Our objective is to sensitize SCCVII cells to ionizing radiation <it>in vitro </it>and <it>in vivo </it>through inhibiting ATM expression using antisense oligodeoxynucleotides (AS-ODNs), and investigate the potential mechanism of radiosensitization.</p> <p>Methods</p> <p>We designed and synthesized AS-ODNs that target ATM mRNA to reduce the ATM expression. The influence on the expression of ATM mRNA and protein in SCCVII cells were analysed by real-time quantitative PCR and western blotting respectively. Clonogenic survival assay was performed to detect the survival ability of SCCVII cells after irradiation, while flow cytometry used to analyse the cell cycle and apoptosis. The volume of solid tumors generated with SCCVII cells was measured, and cell apoptosis was analysed by TUNEL assay after irradiation.</p> <p>Results</p> <p>The relative ATM mRNA and protein expression in SCCVII cells treated with ATM AS-ODNs were decreased to 25.7 ± 3.1% and 24.1 ± 2.8% of that in untreated cells respectively (<it>P </it>< 0.05). After irradiation, the survival fraction (SF) of cells treated with ATM AS-ODNs was lower than that of other groups at the same dose of radiation (<it>P </it>< 0.05), while the percentage of cells in G2/M phase decreased and apoptotic rate of cells increased(<it>P </it>< 0.05). The inhibition rate in SCCVII cells solid tumor exposed to X-ray alone was 23.2 ± 2.7%, while it was 56.1 ± 3.8% in the group which irradiated in combination with the treatment of ATM AS-ODNs (<it>P </it>< 0.05). The apoptotic index for the group irradiated in combination with ATM AS-ODNs injection was 19.6 ± 3.2, which was significantly higher than that of others (<it>P </it>< 0.05)</p> <p>Conclusion</p> <p>Inhibition of ATM expression sensitized SCCVII cells to ionizing radiation <it>in vitro </it>and <it>in vivo</it>. The potential mechanism should be the defective G2/M cell cycle checkpoint control and enhanced radiation-induced apoptosis.</p
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