Moving Margins: Using Marginalia as a Tool for Critical Reflection

Marginalia is the practice of writing notes in the margins of texts as a way to capture ones\u27 thoughts and feelings about the text during reading. It is giving in to the impulse, based on what was read, to stop and record a comment. In this manuscript, we make the connection between marginalia and the visceral responses to text felt by one doctoral student (the second author) taking a course examining language as a place of struggle (hooks, 2004, p. 153). We also demonstrate how marginalia can be used as a qualitative method to document and investigate the way textual interaction facilitates learning. A found poem developed from the marginalia compiled throughout the semester is shared exemplifying the way a critical analysis of personal marginalia can facilitate awareness of transformative processes and highlighting the margins as a transformative space

It's OK not to be OK: Shared Reflections from two PhD Parents in a Time of Pandemic

Adopting an intersectional feminist lens, we explore our identities as single and co‐parents thrust into the new reality of the UK COVID‐19 lockdown. As two PhD students, we present shared reflections on our intersectional and divergent experiences of parenting and our attempts to protect our work and families during a pandemic. We reflect on the social constructions of ‘masculinities’ and ‘emphasized femininities’ as complicated influence on our roles as parents. Finally, we highlight the importance of time and self‐care as ways of managing our shared realities during this uncertain period. Through sharing reflections, we became closer friends in mutual appreciation and solidarity as we learned about each other’s struggles and vulnerabilities

Ferrite attenuator modulation improves antenna performance

Ferrite attenuator inserted into appropriate waveguide reduces the gain of the antenna element which is causing interference. Modulating the ferrite attenuator to change the antenna gain at the receive frequency permits ground tracking until the antenna is no longer needed

Changing the Support of a Spatial Covariate: A Simulation Study

Researchers are increasingly able to capture spatially referenced data on both a response and a covariate more frequently and in more detail. A combination of geostatisical models and analysis of covariance methods may be used to analyze such data. However, very basic questions regarding the effects of using a covariate whose support differs from that of the response variable must be addressed to utilize these methods most efficiently. In this experiment, a simulation study was conducted to assess the following: (i) the gain in efficiency when geostatistical models are used, (ii) the gain in efficiency when analysis of covariance methods are used, and (iii) the effects of including a covariate whose support differs from that of the response variable in the analysis. This study suggests that analyses which both account for spatial structure and exploit information from a covariate are most powerful. Also, the results indicate that the support of the covariate should be as close as possible to the support of the response variable to obtain the most accurate experimental results

Negotiating the Coaching Landscape: Experiences of Black men and women coaches in the United Kingdom

The current article provides a critical examination of the racialised and gendered processes that reinforce disparities in sport coaching by exploring the experiences of Black men and women coaches in the United Kingdom. The findings are based on in-depth qualitative interviews with coaches from two national governing bodies of sport. Using a Critical Race Theory approach and Black feminist lens, the coaches’ narratives illuminate the complex, multifaceted and dynamic ways in which ‘race’, ethnicity and gender are experienced and negotiated by sport coaches. The coaches’ reflections are discussed under three themes: negotiating identities; privilege and blind spots; and systemic discrimination. The narratives from the coaches’ experiences emphasise the need for key stakeholders in sport to recognise the intersectional, structural and relational experiences that facilitate, as well as constrain, the progression of Black coaches in order to challenge racialised and gendered inequalities

‘Because it’s our culture!’ (Re)negotiating the meaning of lobola in Southern African secondary schools

Payment of bridewealth or lobola is a significant element of marriage among the Basotho of Lesotho and the Shona of Zimbabwe. However, the functions and meanings attached to the practice are constantly changing. In order to gauge the interpretations attached to lobola by young people today, this paper analyses a series of focus group discussions conducted among senior students at two rural secondary schools. It compares the interpretations attached by the students to the practice of lobola with academic interpretations (both historical and contemporary). Among young people the meanings and functions of lobola are hotly contested, but differ markedly from those set out in the academic literature. While many students see lobola as a valued part of ‘African culture’, most also view it as a financial transaction which necessarily disadvantages women. The paper then seeks to explain the young people’s interpretations by reference to discourses of ‘equal rights’ and ‘culture’ prevalent in secondary schools. Young people make use of these discourses in (re)negotiating the meaning of lobola, but the limitations of the discourses restrict the interpretations of lobola available to them

Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells

<p>Abstract</p> <p>Background</p> <p>A critical therapeutic challenge in epithelial ovarian carcinoma is the development of chemoresistance among tumor cells following exposure to first line chemotherapeutics. The molecular and genetic changes that drive the development of chemoresistance are unknown, and this lack of mechanistic insight is a major obstacle in preventing and predicting the occurrence of refractory disease. We have recently shown that Regulators of G-protein Signaling (RGS) proteins negatively regulate signaling by lysophosphatidic acid (LPA), a growth factor elevated in malignant ascites fluid that triggers oncogenic growth and survival signaling in ovarian cancer cells. The goal of this study was to determine the role of RGS protein expression in ovarian cancer chemoresistance.</p> <p>Results</p> <p>In this study, we find that RGS2, RGS5, RGS10 and RGS17 transcripts are expressed at significantly lower levels in cells resistant to chemotherapy compared with parental, chemo-sensitive cells in gene expression datasets of multiple models of chemoresistance. Further, exposure of SKOV-3 cells to cytotoxic chemotherapy causes acute, persistent downregulation of RGS10 and RGS17 transcript expression. Direct inhibition of RGS10 or RGS17 expression using siRNA knock-down significantly reduces chemotherapy-induced cell toxicity. The effects of cisplatin, vincristine, and docetaxel are inhibited following RGS10 and RGS17 knock-down in cell viability assays and phosphatidyl serine externalization assays in SKOV-3 cells and MDR-HeyA8 cells. We further show that AKT activation is higher following RGS10 knock-down and RGS 10 and RGS17 overexpression blocked LPA mediated activation of AKT, suggesting that RGS proteins may blunt AKT survival pathways.</p> <p>Conclusions</p> <p>Taken together, our data suggest that chemotherapy exposure triggers loss of RGS10 and RGS17 expression in ovarian cancer cells, and that loss of expression contributes to the development of chemoresistance, possibly through amplification of endogenous AKT signals. Our results establish RGS10 and RGS17 as novel regulators of cell survival and chemoresistance in ovarian cancer cells and suggest that their reduced expression may be diagnostic of chemoresistance.</p