29 research outputs found
Frequentist and Bayesian measures of confidence via multiscale bootstrap for testing three regions
A new computation method of frequentist -values and Bayesian posterior
probabilities based on the bootstrap probability is discussed for the
multivariate normal model with unknown expectation parameter vector. The null
hypothesis is represented as an arbitrary-shaped region. We introduce new
parametric models for the scaling-law of bootstrap probability so that the
multiscale bootstrap method, which was designed for one-sided test, can also
computes confidence measures of two-sided test, extending applicability to a
wider class of hypotheses. Parameter estimation is improved by the two-step
multiscale bootstrap and also by including higher-order terms. Model selection
is important not only as a motivating application of our method, but also as an
essential ingredient in the method. A compromise between frequentist and
Bayesian is attempted by showing that the Bayesian posterior probability with
an noninformative prior is interpreted as a frequentist -value of
``zero-sided'' test
Some Properties Of Somerville Multiple Range Subset-Selection Procedure For three Populations
Somerville (1984) has recently proposed a multiple range subset selection procedure for the case when sample means of size n are obtained from k normal populations with common known variance. It is shown here that when k=3 the probability of correct selection 6f this procedure is between that of Gupta\u27s procedure and p* and strong evidence is presented that the expected subset size of the procedure is lower than that of Gupta\u27s procedure uniformly in parameter values for all p* 0,98
Opinions of seven Mainers on various aspects of health-care reform on both the s
Opinions of seven Mainers on various aspects of health-care reform on both the state and national levels
Procedures With Lower Expected Subset Size Than That Of Gupta Subset-Selection Procedure For 3 Normal Populations
Post-European settlement impacts on erosion and land degradation: a case study using farm reservoir sedimentation in the Eastern Cape, South Africa
Alluvial aquifer characterisation and resource assessment of the Molototsi sand river, Limpopo, South Africa
TRANSITION METAL COMPLEXES OF 1,2-BIS(PHENYLSULFINYL) METHANE AND 1,2-BIS(PHENYLSULFINYL) ETHANE
Evidence that Cellulolysis by an Anaerobic Ruminal Fungus Is Catabolite Regulated by Glucose, Cellobiose, and Soluble Starch
The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex
The basal fungus <i>Allomyces
macrogynus</i> (<i>A. macrogynus</i>) produces motile
male gametes displaying well-studied
chemotaxis toward their female counterparts. This chemotaxis is driven
by sirenin, a sexual pheromone released by the female gametes. The
pheromone evokes a large calcium influx in the motile gametes, which
could proceed through the cation channel of sperm (CatSper) complex.
Herein, we report the total synthesis of sirenin in 10 steps and 8%
overall yield and show that the synthetic pheromone activates the
CatSper channel complex, indicated by a concentration-dependent increase
in intracellular calcium in human sperm. Sirenin activation of the
CatSper channel was confirmed using whole-cell patch clamp electrophysiology
with human sperm. Based on this proficient synthetic route and confirmed
activation of CatSper, analogues of sirenin can be designed as blockers
of the CatSper channel that could provide male contraceptive agents