Spin structure of spin-1/2 baryon and spinless meson production amplitudes in photo and hadronic reactions

The most general spin structures of the spin-1/2 baryon and spinless meson production operator for both photon and nucleon induced reactions are derived from the partial-wave expansions of these reaction amplitudes. The present method provides the coefficients multiplying each spin operator in terms of the partial-wave matrix elements. The result should be useful in studies of these reactions based on partial-wave analyses, especially, when spin observables are considered.Comment: RevTex 34 pages, revised versio

SCINTILLA A European project for the development of scintillation detectors and new technologies for nuclear security

Europe monitors transits using radiation detectors to prevent illicit trafficking of nuclear materials. The SCINTILLA project aims to develop a toolbox of innovative technologies designed to address different usage cases. This article will review the scope, approach, results of the first benchmark campaign and future plans of the SCINTILLA project.Comment: To appear on the Proceedings of the 13th ICATPP Conference on Astroparticle, Particle, Space Physics and Detectors for Physics Applications, Villa Olmo (Como, Italy), 23--27 October, 2013, to be published by World Scientific (Singapore

Creep modelling of 316H stainless steel over a wide range of stress

Abstract Investigation of material creep behaviour in the diffusion controlled creep regime is often unfeasible because of the long duration associated with low stress levels. On the other side, extrapolation from higher creep rates usually provides inaccurate results because of the sharp change in the data trend as a result of the change in the governing deformation mechanism from dislocation to diffusion type controlled creep. Similarly, extrapolation based on creep models, which have been formulated and validated mainly for dislocation type creep (such power law creep with the creep exponent ranging from 6 to 9), underestimates the actual creep rate significantly. Recently, Bonora and Esposito (2010) developed a mechanism-based model (BE model) capable to account for deformation and damage mechanism occurring in creep. In this work the BE model was applied to AISI 316H stainless steel for which considerable creep data in both dislocation and diffusion temperature/stress controlled regime were available. Using the same data set, the predictive capabilities of several models were compared

Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer. Efficacy in combination with hormonal therapy

Background: Data on efficacy of bevacizumab (B) beyond first-line taxane -including regimen (BT) as first-line treatment are lacking. Although preclinical results that anti-angiogenic agents combined with hormonal therapy (HT) could be active, no clinical data exist about combination of maintenance Bevacizumab (mBev) with HT.Methods: Thirty-five patients who experienced a response after first-line BT, were given mBev at the dose of 15 mg/kg every 3 weeks. Among 30 pts with hormonal receptor-positive metastatic breast cancer (MBC), 20 (66.6%) received HT with mBev (mHTBev). Objective of the study was the outcome and safety of mBev and in two groups of patients receiving HT or not.Results: Complete response and partial response was achieved/maintained in 4 (11.4%) and 13 (37.1%) patients, respectively (overall response rate: 48.5%). Clinical benefit was obtained on 23 patients (65.7%). Median of mBev PFS and clinical benefit were 6.8 months (95% CI: 0.8-12.7) and 17.1 months (95% CI :12.2-21.9), respectively. Median PFS of patients who received mHTBev was longer than mBev without HT (13 months and 4.1 months, respectively, p = 0.05). The most common severe toxicities were proteinuria (11.4%) and hypertension (8.5%). No additional toxicity was observed with HTBev.Conclusion: Maintenance bevacizumab with or without anti-hormonal therapy in patients with hormone receptor positive breast cancer is tolerable and associated with long-term clinical outcome; these results encourage the strategy of prolonging bevacizumab until progression in combination with anti-hormonal agents

The proton structure function F2 in the resonance region

Unique measurement of the proton structure function F2 in a wide two-dimensional region of x and Q**2 has been reported. The accessible kinematics covers entire resonance region up to W=2.5 GeV in the Q**2 interval from 0.1 to 4.5 GeV**2. Obtained data allowed for the first time an evaluation of moments of the structure function F2 directly from experimental data as well as an intensive study of the Bloom-Gilman duality phenomenon.Comment: 6 pages, 4 figures, Proceedings of GDH2002 Conference, 3-6 July 2002, Genova, Italy, to be published in World Scientifi

Hydrological control of soil thickness spatial variability on the initiation of rainfall-induced shallow landslides using a three-dimensional model

Thickness and stratigraphic settings of soils covering slopes potentially control susceptibility to initiation of rainfall-induced shallow landslides due to their local effect on slope hydrological response. Notwithstanding the relevance of the assessment of hazard to shallow landsliding at a distributed scale by approaches based on a coupled modelling of slope hydrological response and slope stability, the spatial variability of soil thickness and stratigraphic settings are factors poorly considered in the literature. Under these premises, this paper advances the well-known case study of rainfall-induced shallow landslides involving ash-fall pyroclastic soils covering the peri-Vesuvian mountains (Campania, southern Italy). In such a unique geomorphological setting, the soil covering is formed by alternating loose ash-fall pyroclastic deposits and paleosols, with high contrasts in hydraulic conductivity and total thickness decreasing as the slope angle increases, thus leading to the establishment of lateral flow and an increase of pore water pressure in localised sectors of the slope where soil horizon thickness is less. In particular, we investigate the effects, on hillslope hydrological regime and slope stability, of irregular bedrock topography, spatial variability of soil thickness and vertical hydraulic heterogeneity of soil horizons, by using a coupled three-dimensional hydrological and a probabilistic infinite slope stability model. The modelling is applied on a sample mountain catchment, located on Sarno Mountains (Campania, southern Italy), and calibrated using physics-based rainfall thresholds derived from the literature. The results obtained under five simulated constant rainfall intensities (2.5, 5, 10, 20 and 40 mm h−1) show an increase of soil pressure head and major failure probability corresponding to stratigraphic and morphological discontinuities, where a soil thickness reduction occurs. The outcomes obtained from modelling match the hypothesis of the formation of lateral throughflow due to the effect of intense rainfall, which leads to the increase of soil water pressure head and water content, up to values of near-saturation, in narrow zones of the slope, such as those of downslope reduction of total soil thickness and pinching out of soil horizons. The approach proposed can be conceived as a further advance in the comprehension of slope hydrological processes at a detailed scale and their effects on slope stability under given rainfall and antecedent soil hydrological conditions, therefore in predicting the most susceptible areas to initiation of rainfall-induced shallow landslides and the related I-D rainfall thresholds. Results obtained demonstrate the occurrence of a slope hydrological response depending on the spatial variability of soil thickness and leading to focus slope instability in specific slope sectors. The approach proposed is conceived to be potentially exportable to other slope environments for which a spatial modelling of soil thickness would be possible

Dermoscopy and methyl aminolevulinate: A study for detection and evaluation of field cancerization

Actinic keratosis (AK) is a keratinocyte intraepidermal neoplasia UV light – induced that frequently appears in sun-exposed areas of the skin. Although historically AK was de fi ned as “ precancerous ” , actually it is considered as the earliest stage of squamous cell carcinoma (SCC) in situ. Since AKs can progress into invasive SCC, their treatment isrecommended. AKsrarely developasa singlelesion;usually multiplelesions commonly affect anen- tire area of chronically actinic damaged skin. This has led to the concept of “ fi eld cancerization ” , an area chroni- cally sun-exposed that surrounds peripherally visible lesions, in which are individualized subclinical alterations. One of the main principles endpoint in the management of AKs is the evaluation and the treatment of fi eld cancerization. In this view, in order to detect and quantify fi eld cancerization, we employed a method based on the topical application of methyl aminolevulinate (MAL) and the detection of the fl uorescence emitted by its metabolite Protoporphyrin IX (PpIX); then, considering the extension and the intensity of measured fl uores- cence, we create a score of fi eld cancerization. The results show that patients underwent to daylight PDT had a reduction of total score, from T0 to T2. Whereas in the group untreated we observed a stability of total score or a slightly worse. So, the method and the score used allows to evaluate with a good approximation the dimension of fi eld cancerization and show the modi fi cation of it after treatment

Predicting lymphoma development in patients with Sjögren's syndrome

ABSTRACTIntroduction: The issue of predicting lymphoma in primary Sjogren's syndrome (pSS) starts from its clinical and biologic essence, i.e., an autoimmune exocrinopathy with sicca syndrome, infl..

Applications of microarrays in anatomy and histology

Just few years ago, molecular studies were performed by identifying and testing a single molecule and/or a sample at a time. To date the technological advances have made possible to design systems able to study simultaneously, in a single experiment, thousands of biological molecules in different samples with important scientific implications. Although not yet commonly used in clinical and diagnostic practice, microarrays represent a fundamental innovation, destined to be ever more present in the panorama of biology and medicine. Their versatility, the possibility of making a large number of tests on relatively small amounts of biological material, the speed at which the examinations can be performed, are factors that open new perspectives, offering opportunities unimaginable until now. With the generic term of microarray are combined technologies and applications very different between them, such as: array of gene expression, for comparative genomic hybridization (array-CGH), for single nucleotide polymorphisms studies (SNP), protein arrays and arrays for methylation studies. The applications of microarray technology in basic research are manifold, including functional characterization of genes, identification of metabolic and physiological processes associated genes, identification of genes that regulate specific pathways or cellular responses to specific stimuli, toxicogenomics and pharmacogenomics. Many of these applications have the potential to address important clinical issues such as the identification of genes related to the abnormal biological behavior, the characterization of gene expression profiles for the prediction of disease progression, prognosis, treatment and understanding the genetic basis of multifactorial diseases such as diabetes, atherosclerosis, and cancer