4,137 research outputs found
Renouncing the body. Hegel and thebodily dialectics of self-consciousness
Los lazos políticos y sociales comienzan desde el cuerpo. Contra las lecturas ancladas en la primera Fenomenología del espíritu, este artículo analiza la naturaleza material y corporal del espíritu como segunda naturaleza y su emplazamiento en el desarrollo de la autoconciencia a través de una interpretación inmanente de la Enciclopedia de las Ciencias Filosóficas de Hegel. Se demuestra que la experiencia de la autoconciencia atraviesa dos dialécticas corporales que habilitan la vida política y social: el encuentro mimético entre cuerpos y su colisión en una lucha que culmina en la desigualdad.The body provides the beginning of social and political bonds. Against the interpretations that stay in the first Phenomenology of the spirit, this article analyses the material and bodily nature of the spirit as second nature and its correlation in the development of self-consciousness, by performing an immanent reading of Hegel’s Encyclopaedia of the Philosophical Sciences. The article demonstrates that the self-consciousness’ experience goes through two bodily dialectics that enable social and political life: the mimetic encounter between bodies and its subsequent clash in a struggle that ends in inequality.Fil: de Nicola, Juan Pablo. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Corporations in Modern Political Theory: Positions from Hobbes and Hegel
Nuestro interés en el presente trabajo es, efectivamente, enfocarnos en la temática de las corporaciones, pero centrándonos en dos autores en particular: Thomas Hobbes y Georg Wilhelm Friedrich Hegel. Como se verá, mientras que Hobbes referirá a las corporaciones como empresas, Hegel las aludirá como asociaciones (encargadas de anexar la sociedad civil con el Estado). Es a estos fines que estructuraremos el presente trabajo en tres tiempos. En primer lugar, explicaremos cómo las corporaciones surgen de acuerdo a las teorías de ambos autores. Luego elucidaremos la forma en que las mismas funcionan y se encuentran conformadas. Finalmente, en tercera instancia dilucidaremos la relación que las corporaciones mantienen con el Estado tanto en Hobbes como en Hegel.Our interest in the present work is, indeed, to focus on the subject of corporations, but focusing on two authors in particular: Thomas Hobbes and Georg Wilhelm Friedrich Hegel. As will be seen, while Hobbes will refer to corporations as corporations, Hegel will refer to them as guilds. It is for this purpose that we will structure this paper in three stages. First, we will explain how corporations arise according to the theories of both authors. Then we will elucidate the way in which they function and are formed. Finally, in the third instance, we will elucidate the relationship between corporations and the state in both Hobbes and Hegel.Fil: Ricci Cernadas, Gonzalo. Universidad de Buenos Aires. Facultad de Ciencias Sociales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; Argentin
Hegel and Spinoza: A Possible Encounter Regarding Freedom
Este trabajo analiza una posible vinculación entre los pensamientos políticos de Spinoza y Hegel, utilizando como piedra de toque a la noción de la libertad. Su estructura está puesta en función de un estudio comparativo de acuerdo a tres ejes: la crítica de la libertad entendida como libre arbitrio, la concepción de la libertad como autodeterminación y el vínculo inextricable de la libertad con el Estado. En lugar de la propuesta de Pierre Macherey, que exclama "Hegel o Spinoza", nosotros proclamamos "Hegel y Spinoza".This paper examines a possible bond between the political idea of Spinoza and Hegel, focusing on the notion of freedom as a cornerstone. It is structured in the terms of a comparative study according to three dimensions: the critique of freedom understood as free will, the conception of freedom as self-determination, and the inextricable link between freedom and the State. Instead of Pierre Macherey’s proposal, who claims “Hegel or Spinoza”, we affirm “Hegel and Spinoza”.Fil: Ricci Cernadas, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales; ArgentinaFil: de Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; Argentin
Máquina Ionizadora de Agua para Medicina Alternativa
En este trabajo se ha llevado a cabo el diseño e implementación una máquina ionizadora
de agua para medicina alternativa con el objetivo de presentar una propuesta distinta de
este tipo de dispositivos con la cual se planea un nuevo diseño más compacto y que dé
tanto al operario (especialista) como al paciente más información sobre lo que está pasando
con el agua, tener un control más preciso del funcionamiento y una simplificación en los
controles facilitando así su uso. Esto se logrará realizando pruebas en un ambiente
semicontrolado teniendo en cuenta unas mediciones y cantidades exactas en el proceso de
ionización, esto con el fin de que el usuario/operario al realizar dicho proceso pueda liberar
toxinas, desactivar de manera más eficaz los radicales libres y erradicar impurezas del
sistema linfático del paciente, siendo estos recreados en una clínica donde no se puede
estar durante todo el proceso acompañando al paciente.
El mecanismo se realizó basado en el funcionamiento de una máquina ionizadora comercial
a la cual se le realizaron mejoras significando una disminución en su tamaño y otorgando
un sistema de control de tiempo y pH haciendo necesaria la creación de una carcasa
usando impresión 3D para la adecuación del circuito y periféricos. También fue necesario
el uso de dos fuentes de alimentación para evitar uno de los problemas más comunes con
este tipo de equipos la cual es el daño total o parcial de los componentes controlados por
el microcontrolador.In this work we have carried out the design and implementation of a water ionizing machine
for alternative medicine with the objective of presenting a different proposal of this type of
machines with which a new more compact design is planned and that gives both the operator
(specialist) and the patient more information about what is happening with the water, to have
a more precise control of the operation and a simplification in the controls thus facilitating its
use. This will be achieved by performing tests in a semi-controlled environment considering
exact measurements and quantities in the ionization process, so that the user/operator can
release toxins, deactivate free radicals more effectively and eradicate impurities from the
patient's lymphatic system, these being recreated in a clinic where it is not possible to be
with the patient during the entire process.
The mechanism was made based on the operation of a commercial ionizing machine to
which improvements were made meaning a decrease in its size and providing a time and
pH control system making necessary the creation of a housing using 3D printing for the
adequacy of the circuit and peripherals. It was also necessary to avoid one of the most
common problems with this type of machinery, which is the total or partial damage of the
components controlled by the microcontrolle
The ERα membrane pool modulates the proliferation of pituitary tumours
The molecular mechanisms underlying the ERα nuclear/cytoplasmic pool that modulates pituitary cell proliferation have been widely described, but it is still not clear how ERα is targeted to the plasma membrane. The aim of this study was to analyse ERα palmitoylation and the plasma membrane ERα (mERα) pool, and their participation in E2-triggered membrane-initiated signalling in normal and pituitary tumour cell growth. Cell cultures were prepared from anterior pituitaries of female Wistar rats and tumour GH3 cells, and treated with 10 nM of oestradiol (E2). The basal expression of ERα was higher in tumour GH3 than in normal pituitary cells. Full-length palmitoylated ERα was observed in normal and pituitary tumour cells, demonstrating that E2 stimulation increased both, ERα in plasma membrane and ERα and caveolin-1 interaction after short-term treatment. In addition, the Dhhc7 and Dhhc21 palmitoylases were negatively regulated after sustained stimulation of E2 for 3 h. Although the uptake of BrdU into the nucleus in normal pituitary cells was not modified by E2, a significant increase in the GH3 tumoural cell, as well as ERK1/2 activation, with this effect being mimicked by PPT, a selective antagonist of ERα. These proliferative effects were blocked by ICI 182780 and the global inhibitor of palmitoylation. These findings indicate that ERα palmitoylation modulated the mERα pool and consequently the ERK1/2 pathway, thereby contributing to pituitary tumour cell proliferation. These results suggest that the plasma membrane ERα pool might be related to the proliferative behaviour of prolactinoma and may be a marker of pituitary tumour growth.Fil: Sosa, Liliana del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Centro de Microscopía Electrónica; ArgentinaFil: Petiti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Centro de Microscopía Electrónica; ArgentinaFil: Picech, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Centro de Microscopía Electrónica; ArgentinaFil: Chumpen Ramirez, Sabrina Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Pérez, Pablo Aníbal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Centro de Microscopía Electrónica; ArgentinaFil: de Paul, Ana Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Centro de Microscopía Electrónica; ArgentinaFil: Valdez Taubas, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Guitierrez, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Centro de Microscopía Electrónica; ArgentinaFil: Torres, Alicia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Centro de Microscopía Electrónica; Argentin
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Ion Transport at Polymer–Argyrodite Interfaces
Solid-state electrolytes, particularly polymer/ceramic composite electrolytes, are emerging as promising candidates for lithium-ion batteries due to their high ionic conductivity and mechanical flexibility. The interfaces that arise between the inorganic and organic materials in these composites play a crucial role in ion transport mechanisms. While lithium ions are proposed to diffuse across or parallel to the interface, few studies have directly examined the quantitative impact of these pathways on ion transport and little is known about how they affect the overall conductivity. Here, we present an atomistic study of lithium-ion (Li+) transport across well-defined polymer–argyrodite interfaces. We present a force field for polymer–argyrodite interfacial systems, and we carry out molecular dynamics and enhanced sampling simulations of several composite systems, including poly(ethylene oxide) (PEO)/Li6PS5Cl, hydrogenated nitrile butadiene rubber (HNBR)/Li6PS5Cl, and poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP)/Li6PS5Cl. For the materials considered here, Li-ion exhibits a preference for the ceramic material, as revealed by free energy differences for Li-ion between the inorganic and the organic polymer phase in excess of 13 kBT. The relative free energy profiles of Li-ion for different polymeric materials exhibit similar shapes, but their magnitude depends on the strength of interaction between the polymers and Li-ion: the greater the interaction between the polymer and Li-ions, the smaller the free energy difference between the inorganic and organic materials. The influence of the interface is felt over a range of approximately 1.5 nm, after which the behavior of Li-ion in the polymer is comparable to that in the bulk. Near the interface, Li-ion transport primarily occurs parallel to the interfacial plane, and ion mobility is considerably slower near the interface itself, consistent with the reduced segmental mobility of the polymer in the vicinity of the ceramic material. These findings provide insights into ionic complexation and transport mechanisms in composite systems, and will help improve design of improved solid electrolyte systems
Rapid Weight Loss of Up to Five Percent of the Body Mass in Less Than 7 Days Does Not Affect Physical Performance in Official Olympic Combat Athletes With Weight Classes: A Systematic Review With Meta-Analysis
Given the relevance of the effects that weight loss can generate on the physical performance in athletes, this study performed a systematic review with meta-analysis of the published literature on rapid weight loss (RWL) and examined its impact on the physical performance in Official Olympic combat sports athletes. The “Preferred Reporting Items for Systematic Reviews and Meta-Analysis” (PRISMA) guidelines were followed to ensure an ethical and complete reporting of the findings. PubMed, SPORT Discus, and EBSCO were the electronic databases explored for article retrieval and selection. The following string was applied: “RWL” OR “weight loss” OR “weight reduction” AND “judo” OR “wrestling” or “taekwondo” or “boxing” AND “performance.” Based on the quality analysis, conducted according to the “Tool for the assessment of study quality and reporting in exercise training studies” (TESTEX), ten articles achieved a score >6 points. The meta-analysis showed a significant difference in pre- vs. postweight loss (p = 0.003) and no effects in pre- vs. post-power and strength performance analysis (p > 0.05 for both results). Based on our systematic review and metaanalysis of the literature, RWL up to ≤5% of the body mass in less than 7 days does not influence performance outcomes in Official Olympic combat athletes with weight classes, considering the strength and power measures
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Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
This corrects the article DOI: 10.1038/sdata.2017.179
Epidemiologic Features and Control Measures during Monkeypox Outbreak, Spain, June 2022
During June 2022, Spain was one of the countries most affected worldwide by a multicountry monkeypox outbreak with chains of transmission without identified links to disease-endemic countries. We provide epidemiologic features of cases reported in Spain and the coordinated measures taken to respond to this outbreak.S
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