Attitudes of Undergraduate Students Towards Self-employment in Yemen Public Universities

To the best of the authors’ knowledge, the intention of undergraduate students towards self-employment has not been yet studied in Yemen. We aimed to study the intentions of undergraduate students towards self-employment as a career choice. Since most literature agrees that future intention towards self-employment can be determined by using the Theory of Reasoned Action (TRA), this theory is used as a theoretical framework in this study. A questionnaire survey was completed by a random sample (n = 451) of university students, undergraduate level, at one of the major public universities in Yemen. Results were based on descriptive analysis and multivariate statistical analysis including crosstabs, bivariate correlation and binary logistic regressions. Results of correlation test indicates that there are positive and significant correlations between dependent variable students’ intention to be self-employed and independent variables; entrepreneurial awareness (r = .338, n = 401, P < .00) and attitude (r =.569, n = 401, P < .00), whereas social norms variable, has derived low and not significant correlation value (r = .066, n = 373, P >.20). Binary logistic regression results showed that both variables, entrepreneurial awareness (ß = 2.154, p < 0.005) and attitude (ß = 3.117, p < 0.005), are significantly correlated with the students’ intention to start a business, whereas there is no significant correlation between the social norms and the students’ intention to start a business (ß = – 0.153, p > 0.744). Our study suggests that providing entrepreneurial capabilities among citizens may improve social norms toward entrepreneurship. The study also makes a valuable contribution to the under-researched context of Yemen entrepreneurship. Keywords: Self-employment intention, Undergraduate students, Yemen, Theory of Reasoned Action. DOI: 10.7176/RHSS/10-2-08 Publication date: January 31st 202

Coordinated Regulation by AgrA, SarA, and SarR To Control agr Expression in Staphylococcus aureus

The agr locus of Staphylococcus aureus is composed of two divergent transcripts (RNAII and RNAIII) driven by the P2 and P3 promoters. The P2-P3 intergenic region comprises the SarA/SarR binding sites and the four AgrA boxes to which AgrA binds. We reported here the role of AgrA, SarA, and SarR on agr P2 and P3 transcription. Using real-time reverse transcription (RT)-PCR and promoter fusion studies with selected single, double, triple, and complemented mutants, we showed that AgrA is indispensable to agr P2 and P3 transcription, whereas SarA activates and SarR represses P2 transcription. In vitro runoff transcription assays revealed that AgrA alone promoted transcription from the agr P2 promoter, with SarA enhancing it and SarR inhibiting agr P2 transcription in the presence of AgrA or with SarA and AgrA. Electrophoretic mobility shift assay (EMSA) analysis disclosed that SarR binds more avidly to the agr promoter than SarA and displaces SarA from the agr promoter. Additionally, SarA and AgrA bend the agr P2 promoter, whereas SarR does not. Collectively, these data indicated that AgrA activates agr P2 and P3 promoters while SarA activates the P2 promoter, presumably via bending of promoter DNA to bring together AgrA dimers to facilitate engagement of RNA polymerase (RNAP) to initiate transcription

Entrepreneurial Intentions of Undergraduate Students in Yemen: Applying the Theory of Planned Behaviour

The intention of undergraduate students towards entrepreneurial was not yet studied in Yemen. We aimed to study the intentions of undergraduate students towards an entrepreneurial activity. The cross-sectional study design was used. This study was used the questionnaire developed to test theory of planned behavioral in the field of entrepreneurship. The Cronbach’s alpha test was used to test the reliability. Pearson correlation analysis was used to assess the relationship between study variables. Multiple regression models were applied. All analysis was performed with SPSS. A total of 432 undergraduate students included from the Sana’a University in Yemen. Out of this, 74.5% was male students and 25.5% were female students. The results of correlation test indicate that entrepreneurial intentions have a strong positive correlation with personal attitude (r = .917), subjective norms (r = 0.963) and perceived behavioral (r = 0 .955). A statistically significant association was found between perceived behavioral control (β = 0. 420, p < 0.001), subjective norms (β = 0. 524, p < 0.001) and the intention to start a business. However, non-significant association was found between personal attitude and entrepreneurial intention (β = -0.040; p < 0.169). Our study suggested that providing entrepreneurial capabilities among citizens, may improve societal norms and individual attitudes toward entrepreneurship. However, we could not found a statistically significant association between attitude and entrepreneurial intention. Keywords: Entrepreneurial intention, Undergraduate students, Yemen, Theory of Planned Behaviour DOI: 10.7176/EJBM/11-35-04 Publication date: December 31st 201

Research on the Current Situation of Mental Health in Rural Community and Urban Community

There are few studies on the treatment orientation of psychological counseling and psychotherapy practitioners in China. Additionally, integrative therapy as the first choice is much commoner in less developed areas and among unsupervised practitioners, which reflects the risk of technical confusion relating to the use of integrative therapy in China. The counseling and psychotherapy practitioners are treated as "variables", and researchers are concerned because these "variables" can have a significant impact on the course of treatment and outcomes. Therefore, we analyze the effects of socioeconomic development level on practitioners' treatment orientation. Based on the results, in addition to areas of employment, urban stratification and practitioners’ system factors, gender, age, education, professional background, work hours, and other factors affect psychological counseling and psychological treatment practitioners

The Novel Protease Activities of JMJD5–JMJD6–JMJD7 and Arginine Methylation Activities of Arginine Methyltransferases Are Likely Coupled

The surreptitious discoveries of the protease activities on arginine-methylated targets of a subfamily of Jumonji domain-containing family including JMJD5, JMJD6, and JMJD7 pose several questions regarding their authenticity, function, purpose, and relations with others. At the same time, despite several decades of efforts and massive accumulating data regarding the roles of the arginine methyltransferase family (PRMTs), the exact function of this protein family still remains a mystery, though it seems to play critical roles in transcription regulation, including activation and inactivation of a large group of genes, as well as other biological activities. In this review, we aim to elucidate that the function of JMJD5/6/7 and PRMTs are likely coupled. Besides roles in the regulation of the biogenesis of membrane-less organelles in cells, they are major players in regulating stimulating transcription factors to control the activities of RNA Polymerase II in higher eukaryotes, especially in the animal kingdom. Furthermore, we propose that arginine methylation by PRMTs could be a ubiquitous action marked for destruction after missions by a subfamily of the Jumonji protein family

The CD27L and CTP1L Endolysins Targeting <i>Clostridia</i> Contain a Built-in Trigger and Release Factor

<div><p>The bacteriophage ΦCD27 is capable of lysing <i>Clostridium difficile</i>, a pathogenic bacterium that is a major cause for nosocomial infection. A recombinant CD27L endolysin lyses <i>C. difficile</i> in vitro, and represents a promising alternative as a bactericide. To better understand the lysis mechanism, we have determined the crystal structure of an autoproteolytic fragment of the CD27L endolysin. The structure covers the C-terminal domain of the endolysin, and represents a novel fold that is identified in a number of lysins that target Clostridia bacteria. The structure indicates endolysin cleavage occurs at the stem of the linker connecting the catalytic domain with the C-terminal domain. We also solved the crystal structure of the C-terminal domain of a slow cleaving mutant of the CTP1L endolysin that targets <i>C. tyrobutyricum</i>. Two distinct dimerization modes are observed in the crystal structures for both endolysins, despite a sequence identity of only 22% between the domains. The dimers are validated to be present for the full length protein in solution by right angle light scattering, small angle X-ray scattering and cross-linking experiments using the cross-linking amino acid p-benzoyl-L-phenylalanine (pBpa). Mutagenesis on residues contributing to the dimer interfaces indicates that there is a link between the dimerization modes and the autocleavage mechanism. We show that for the CTP1L endolysin, there is a reduction in lysis efficiency that is proportional to the cleavage efficiency. We propose a model for endolysin triggering, where the extended dimer presents the inactive state, and a switch to the side-by-side dimer triggers the cleavage of the C-terminal domain. This leads to the release of the catalytic portion of the endolysin, enabling the efficient digestion of the bacterial cell wall.</p></div

Comparison of functional outcomes following early and delayed arthroscopic repair for traumatic and non-traumatic rotator cuff injuries

Abstract Background The effects of the timing of surgical repair on the outcomes of traumatic and non-traumatic rotator cuff injuries (RCI) remain elusive. Thus, this study aimed to compare differences in outcomes following the repair of traumatic and non-traumatic RCI at varying time points. Methods The study population comprised 87 patients with traumatic and non-traumatic RCI who underwent arthroscopic rotator cuff repair and were followed up for a minimum of 6 months. Next, the trauma and the non-trauma groups were stratified into subgroups according to the time of injury (early repair: occurring within 3 months; delayed repair: occurring after 3 months). Measurements before and after surgical interventions were compared to evaluate the effect of the duration of RCI on the functional status of patients in the trauma and non-trauma groups. Primary evaluation indices included the Visual Analog Scale (VAS) pain score, American Shoulder and Elbow Surgeons (ASES) score, Constant shoulder function score, and the University of California, Los Angeles (UCLA) shoulder score. Secondary evaluation indices consisted of shoulder range of motion (ROM), postoperative rotator cuff retear rate, and incidence of joint stiffness. Results Among the 40 patients in the trauma group, 22 underwent early repair, whereas the remaining 18 underwent delayed repair. In the non-trauma group consisting of 47 patients, 18 underwent early repair, whereas the remaining 29 underwent delayed repair. The minimum clinical follow-up time was 6 months, with an average follow-up time of 10.2 months. During postoperative follow-up, 1 and 6 patients who underwent early and delayed repair experienced re-tear in the trauma group, respectively. Contrastingly, 3 and 8 patients who underwent early and delayed repair presented with re-tear in the non-trauma group, respectively. Conclusion Early repair of traumatic RCI yielded superior outcomes, including improved range of motion, lower pain symptoms, and lower risk of postoperative re-tears compared to delayed repair. Additionally, non-surgical treatment is recommended as the preferred approach for patients with non-traumatic RCI

Improving text classification using local latent semantic indexing

Latent Semantic Indexing (LSI) has been shown to be extremely useful in information retrieval, but it is not an optimal representation for text classification. It always drops the text classification performance when being applied to the whole training set (global LSI) because this completely unsupervised method ignores class discrimination while only concentrating on representation. Some local LSI methods have been proposed to improve the classification by utilizing class discrimination information. However, their performance improvements over original term vectors are still very limited. In this paper, we propose a new local LSI method called “Local Relevancy Weighted LSI ” to improve text classification by performing a separate Single Value Decomposition (SVD) on the transformed local region of each class. Experimental results show that our method is much better than global LSI and traditional local LSI methods on classification within a much smaller LSI dimension. 1