32 research outputs found
Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile
This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluated in vivo at water immersion restraint conditions. The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. Prophylactic single-dose 1 mg/kg treatment with (2-hydroxyphenyl)thioacetyl derivatives of L-lysine and L-proline efficiently decreases up to 86% stress-induced stomach ulceration in rats. Discovered small-molecule antiulcer agents modulate activities of gastric mucosa tissue superoxide dismutase, catalase, and xanthine oxidase in concerted directions. Gastroprotective effect of (2-hydroxyphenyl)thioacetyl derivatives of L-lysine and L-proline at least partially depends on the correction of gastric mucosa oxidative balance
MM-GBSA and MM-PBSA performance in activity evaluation of AMPA receptor positive allosteric modulators
MM-GBSA and MM-PBSA performance in activity evaluation of AMPA receptor positive allosteric modulator
Immobilized Phthalocyanine Aluminum Complexes in Synthesis of α–Aminophosphonates. Phosphorylation of Various Imines
<div><p>GRAPHICAL ABSTRACT</p><p></p></div
Phosphonium-Iodonium Ylides with Heteroatomic Groups in the Synthesis of Annelated P‑Containing Heterocycles
The preparation and chemistry of
novel sulfonyl- and phosphoryl-derived
λ<sup>3</sup>-iodanes are reported. These compounds with three
different heteroatoms attached to a negatively charged C atom represent
potentially useful reagents that combine in one molecule the synthetic
advantages of a phosphonium ylide and an iodonium salt. Specifically,
they can react with a number of acetylenes, leading to hitherto unknown
sulfonyl- and phosphoryl-substituted phosphinolines, phosphininothiophenes,
and a novel type of annelated P-containing heterocycleî—¸phosphininopyrazole
Phosphonium-Iodonium Ylides with Heteroatomic Groups in the Synthesis of Annelated P‑Containing Heterocycles
The preparation and chemistry of
novel sulfonyl- and phosphoryl-derived
λ<sup>3</sup>-iodanes are reported. These compounds with three
different heteroatoms attached to a negatively charged C atom represent
potentially useful reagents that combine in one molecule the synthetic
advantages of a phosphonium ylide and an iodonium salt. Specifically,
they can react with a number of acetylenes, leading to hitherto unknown
sulfonyl- and phosphoryl-substituted phosphinolines, phosphininothiophenes,
and a novel type of annelated P-containing heterocycleî—¸phosphininopyrazole