Investigando o papel mediador da agilidade organizacional no efeito do capital intelectual sobre o desempenho do enfermeiro no Hospital Shahid Beheshti de Yasuj

Aim and literature: organizations face an environment which is characterized by increasing complexity and globalization and dynamism in the ultra-competitive era. So, the main aim of the present study is analyzing the effect of intellectual capital on nurses' job performance by considering the mediating role of organizational agility.The present research is an applied, descriptive, survey and correlative research in terms of its aim and methodology which was conducted in 2017 periodically. The statistical population of this study included the nurses of Shahid Beheshti Hospital of Yasuj. They were 320 persons at the time of study. The sample size was 174 persons which were selected by a stratified- randomized method. The standard questionnaire was used for gathering information. The validity and reliability of this questionnaire was confirmed. Pearson correlation test, structural equations modeling and bootstrap test were used for analyzing the relationship between variables, measuring the fit of the research model and testing the hypotheses by SPSS and Smart Pls software respectively. Results suggested that the proposed model of research has a good fit and these results are in accordance with positive and significant effect of intellectual capital on nurses' job performance. Findings of this research also showed that intellectual capital has a direct, positive and significant effect on nurses' job performance with the moderating role of agility. The results showed that hospital agility can be an important factor in improving the nurses' job performance and thus strengthening the intellectual capital of the hospital.Objetivo y literatura: las organizaciones se enfrentan a un entorno caracterizado por el aumento de la complejidad y la globalización y el dinamismo en la era ultracompetitiva. Por lo tanto, el objetivo principal del presente estudio es analizar el efecto del capital intelectual en el desempeño laboral de las enfermeras al considerar el papel mediador de la agilidad organizacional.  La presente investigación es una investigación aplicada, descriptiva, encuesta y correlativa en términos de su objetivo y metodología que se llevó a cabo en 2017 periódicamente. La población estadística de este estudio incluyó a las enfermeras del Hospital Shahid Beheshti de Yasuj. Eran 320 personas en el momento del estudio. El tamaño de la muestra fue de 174 personas que fueron seleccionadas por un método estratificado y aleatorizado. El cuestionario estándar se usó para recopilar información. La validez y fiabilidad de este cuestionario fue confirmada. La prueba de correlación de Pearson, el modelado de ecuaciones estructurales y la prueba de arranque se usaron para analizar la relación entre variables, medir el ajuste del modelo de investigación y probar las hipótesis mediante el software SPSS y Smart Pls, respectivamente. los resultados sugirieron que el modelo propuesto de investigación encaja bien y estos resultados están de acuerdo con el efecto positivo y significativo del capital intelectual en el desempeño laboral de las enfermeras. Los resultados de esta investigación también mostraron que el capital intelectual tiene un efecto directo, positivo y significativo en el desempeño laboral de las enfermeras con el papel moderador de la agilidad. Los resultados mostraron que la agilidad hospitalaria puede ser un factor importante para mejorar el desempeño laboral de las enfermeras y así fortalecer el capital intelectual del hospital.O objetivo principal do presente estudo é avaliar o comprometimento organizacional de professores do ensino médio baseado na teoria de Herzberg sobre a motivação dos fatores. Um método de pesquisa descritiva é usado neste estudo. A população estatística deste estudo inclui os professores da escola secundária da administração educacional da cidade de Jahrom. Havia 330 pessoas no momento do estudo. O tamanho da amostra foi de 178 pessoas, de acordo com a tabela de Kerjesi-Morgan, e a amostragem foi realizada por método estratificado e randomizado. Dois problemas de comprometimento organizacional (Allen e Meyer) e motivação foram utilizados pelas razões dos fatores (expectativa de trabalho) (Lussier) para coletar informações. A validade e confiabilidade dos questionários foram confirmadas. indicadores SIRS como média e desvio padrão, amostra teste t, coeficiente de correlação de Pearson, t-teste em amostras independentes, análise de regressão multivariada e análise de variância através das partes de estatística descritiva e estatística inferencial para analisar os dados respectivamente. Os resultados dos dados analisados mostraram que existe uma relação significativa entre fatores de higiene motivacional e comprometimento organizacional. Não há diferença significativa entre os fatores de higiene de professores do sexo masculino e feminino, mas a taxa de fatores de higiene das professoras é maior do que a dos professores do sexo masculino. Tampouco há uma diferença significativa entre o comprometimento da organização do professor, mas a taxa de professores com mais do que a categoria de professores com bacharelado e mestrado em artes

Effect of conjugated linoleic acid, vitamin E and their combination on lipid profiles and blood pressure of Iranian adults with active rheumatoid arthritis

The aim of this study was to assess the impact of conjugated linoleic acids (CLAs), vitamin E, and combination of these nutrients on serum lipid profiles and blood pressure (BP) in patients with active rheumatoid arthritis (RA). In a randomized, double-blind, placebo-controlled trial, 87 patients with active RA were divided into four groups receiving one of the following daily supplements for three months: Group C: CLAs 2.5 g equivalent to 2 g mixture of cis 9-trans 11 and trans 10-cis12 CLAs in a rate of 50/50; Group E: vitamin E: 400 mg; Group CE: CLAs and vitamin E at above doses: Group P: placebo. After supplementation, SBP levels decreased significantly in the group C in comparison with groups E and P and mean arterial pressure reduced significantly in groups C and CE. There weren’t significant differences in the levels of prostaglandin E2 (PGE2), triglycerides, cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL/HDL, cholesterol/HDL, fasting blood sugar, C-reactive protein (CRP), arylestrase activity, platelet count and body mass index between groups. CRP dropped nonsignificantly in groups P, C, E and CE (19%, 24%, 55%, and 39%, respectively). Erythrocytes sedimentation rate levels decreased in groups C, E and CE (P ≤ 0.05, P ≤ 0.05, P ≤ 0.001, respectively). It is concluded that supplementation of CLAs decreased BP and vitamin E decreased CRP. Therefore cosupplementation of CLAs and vitamin E might be profitable for heart disease prevention in RA patients

Effect of Genistein and L-Carnitine and Their Combination on Gene Expression of Hepatocyte HMG-COA Reductase and LDL Receptor in Experimental Nephrotic Syndrome

Background: Nephrotic syndrome is a disorder that leads to hyperlipidemia. L-carnitine and genistein can effect on lipid metabolism and the syndrome. In the present study, we have delved into the separate and the twin-effects of L-carnitine and genistein on the gene expressions of HMG-COA reductase and LDL receptor in experimental nephrotic syndrome. Methods: In this controlled experimental study, 50 male Sprague–Dawley rats were randomly divided into five groups: NC (normal-control), PC (patient-control), LC (L-carnitine), G (genistein), LCG (L-carnitine-genistein). Adri-amycin was used for inducing nephrotic syndrome and the spot urine samples and urine protein-to-creatinine ratio were measured. Hepatocytic RNA was extracted and real-time PCR was used for HMG-COA Reductase and LDL receptor gene Expression measurement. Results: The final weight of the patients groups were lower than the NC group (P=0.001), and weight gain of the NC group was higher than the other groups (P<0.001). The proteinuria and urine protein-to-creatinine ratio showed sig-nificant differences between PC group and LC, G and LCG groups at week 7 (P<0.001). The expression of HMG-COA Reductase mRNA down regulated in LC, G and LCG groups in comparison with PC group (P<0.001). ΔCT of LDLr mRNA showed significant differences between the PC group and the other patient groups (P<0.001). Conclusion: This study shows a significant decreasing (P<0.001) and non-significant increasing trend in HMG-COA Reductase and LDLr gene expression, respectively, and synergistic effect of L-carnitine and genistein on these genes in experimental nephrotic syndrome

Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD

Objective: Adiponectin is a unique anti-atherogenic adipocytokine. Regulation of adiponectin secretion is dysfunctional in cardiovascular diseases. The current trial study assessed the effects of omega-3 fatty acids with or without vitamin E on adiponectin gene expression in peripheral blood mononuclear cells and serum adiponectin and adipocyte fatty acid-binding protein (A-FABP; also called ap2 and FABP4) levels in patients with coronary artery disease (CAD). Methods: This randomized, double-blind, placebo-controlled trial included 67 male patients with CAD. First of the four group of participants received 4 g/day omega-3 fatty acids plus 400 IU/day vitamin E (OE), second group 4 g/day omega-3 fatty acids plus vitamin E placebo (OP), or both omega-3 fatty acid and vitamin E placebos (PP) for 8 weeks. Adiponectin gene expression and serum adiponectin and FABP4 levels were evaluated. Results: The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. In the OP group, serum adiponectin levels did not change significantly. Consumption of omega-3 fatty acids with and without vitamin E had no significant effect on adiponectin gene expression. Conclusion: Omega-3 fatty acids with or without vitamin E improve adiponectin levels in patients, without any significant changes in adiponectin gene expression. This nutritional intervention may prevent complications in patients with CAD because of increased adiponectin levels. (Anatol J Cardiol 2015; 15: 981-9

Evaluating cytotoxic effects of recombinant fragaceatoxin C pore forming toxin against AML cell lines

Objective(s): Current therapeutic strategies for cancer are associated with side effects and lack of specificity in treatments. Biological therapies including monoclonal antibodies and immune effectors have been the subject of multiple research projects. Pore-forming proteins may become the other biological strategy to overcome the problems associated with current treatments. But detailed mechanisms of their action on target membranes remained to be elucidated. We aimed to study the cytotoxic effects of recombinant form of fragaceatoxin C on AML cell lines HL-60 and KG-1. Materials and Methods: We cloned the FraC gene in pET-28a (+) bacterial expression vector and the expressed recombinant FraC protein was purified by affinity chromatography. Then, cytotoxic effects of the recombinant protein were examined on two AML cell lines, HL-60 and KG-1. Effects of serum and calcium ion were explored by hemolysis assay in more details. Results: Our results showed that the recombinant C-terminal polyhistidine-tagged FraC protein has potent cytotoxic effects on both AML cell lines, with IC50=5.6, and 4.6 µg.ml-1 for HL-60 and KG-1 cells, respectively. Serum showed dose-dependent and also time-dependent inhibitory effects on the hemolytic and cytotoxic activities of the FraC protein. Pre-incubation of the toxin with different concentrations of calcium ion also inhibited hemolytic activity of FraC toxin.Conclusion: Results of the present study showed that FraC has potential anti-tumor effects. By detailed investigation of the inhibition mechanism of serum and calcium effects in the future, it can be possible to design target sites for clinical applications of the toxin

Development and psychometric properties of social exclusion questionnaire for Iranian divorced women

Background: Divorce, especially in women, could be assessed from socio-cultural perspective as well as psychological viewpoint. This assessment requires cultural adopted as well as valid and reliable questionnaire. This study aimed to develop and assess the psychometric properties of a questionnaire in order to address social consequences in Iranian divorced women.Methods: This was an exploratory mixed method study conducted during 2012 to 2014. According to the grounded theory approach in the first phase, social exclusion was extracted as a core of understanding process in participants. Based on, 47 preliminary generated items reliability and validity were assessed. In the second phase, the divorced women were recruited from a safe community center in Tehran through convenience sampling.Results: Exploratory factor analysis conducted on the questionnaires of 150 divorced women with mean age 41.76&plusmn;8.49 yr, in that, indicated five dimensions, discriminative marital status, economic dependence on marital status, exclusionary marital status, and traumatic marital status health risks and, frightening marital status that jointly accounted for the 64% of the variance observed. An expert panel approved the face and content validity of the developed tool. The Cronbach&rsquo;s alpha coefficient and the Intra-class Correlation Coefficient were found to be 0.70 and 0.85, respectively.Conclusion: The present study provided a valid and reliable measure as Social Exclusion Questionnaire in Iranian divorced women (SEQ-IDW) to address social post-divorce consequences, which might help to improve women&rsquo;s social health

Divorce from a divorcee woman's perspectives: A qualitative study

Introduction: Divorce is an unexpected change in marital life. This change affects physical and psychological health. Divorce is a complex phenomenon which can be conceptualized from different perspectives. Aim of the present study was to conceptualize divorce from Iranian women's perspectives. Method: A qualitative content analysis approach was employed. Using purposeful sampling, data collected from 26 women with divorce experience. In-depth semi-structured interviews and focus group discussions were used to gather information. Results: The findings suggest two main themes: "concept" and "process of experience". Each theme was divided into sub-themes as general vocabulary, especially lexical (experience), perceived conflict, versusbelief experience, and traumatic. Conclusion: Concept of divorce is driven from social believes. Divorce affects health. In fact, divorce not only is a socio-cultural issue, but also, a social health determinant. Thus, any program in women health promotion needs to consider divorcee women's perspective. We came to conclusion that, several factors make the meaning of divorce. Furthermore, these components are subject to a separated woman's perceived experiences, perceptions, social beliefs, and gender. Keywords: Divorce, Conceptualizing, Women health, women perspective, divorcee women, Qualitative Content analysi

Vitamin D suppresses cellular pathways of diabetes complication in liver

Objective(s): The aim of this study was to investigate the effect of vitamin D on glucose metabolism, as well as the expression of five key genes involved in the development of diabetes complications in liver tissue of diabetic rats. Materials and Methods: Twenty-four male Sprague–Dawley rats were randomly divided into three groups (8 rats in each group). The first group served as control and the other two groups received an intraperitoneal injection of 45 mg/kg streptozotocin to develop diabetes. Groups were treated for four weeks either with placebo or vitamin D (two injections of 20000 IU/kg). Thereafter, serum levels of glucose, insulin and HbA1c were assessed. Liver tissue was examined for the level of advanced glycation end products (AGEs) and the gene expression of AGE cellular receptor (AGER), glyoxalase-1 (GLO-1), aldose reductase (AR), O-linked N-acetylglucosamine transferase (OGT) and glutamine/ fructose-6-phosphate aminotransferase (GFAT). Results: Vitamin D injection resulted in a significant increase in plasma level of 25-hydroxycholecalciferol, which could improve hyperglycemia about 11% compared to placebo-receiving diabetic rats (P=0.005). Insulin level increased as a result of vitamin D treatment compared to control (3.31±0.65 vs. 2.15±0.79; P= 0.01). Serum HbA1c and liver AGE concentrations had a slight but insignificant reduction following vitamin D intake. Moreover, a significant decline was observed in gene expression of AGER and OGT in liver tissue (P=0.04 and PConclusion: Vitamin D might contribute in ameliorating diabetes complications not only by improving blood glucose and insulin levels, but also by suppressing AGER and OGT gene expression in the liver

Seroprevalence of Immunoglobulin G antibodies against pertussis toxin among asymptomatic medical students in the west of Iran: a cross sectional study

<p>Abstract</p> <p>Background</p> <p>Pertussis is a highly communicable, vaccine-preventable respiratory infection. Immune response against this disease can be induced by infection or vaccination. Protection after childhood vaccination is minimal after ten years. Our aim was to assess pertussis immunity state in a population of healthy young medical students.</p> <p>Methods</p> <p>In this seroepidemiological survey, blood samples were obtained from 163 first-year medical students in Hamedan University, Iran. Serum level of IgG against pertussis toxin (IgG-PT) was measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. For qualitative assessment, IgG-PT levels more than 24 unit (U)/ml were considered positive. Data was analysed qualitatively and quantitatively considering gender and age groups.</p> <p>Results</p> <p>There were 83 males and 80 females, with a mean age of 19.48 years, Prevalence of IgG-PT was 47.6% with mean level of 71.7 u/ml (95% confidence interval: 68.1–75.3). No statistically significant difference was observed with respect to sero-positivity of IgG-PT between males and females (45 cases (54%) vs. 34 cases (42%); P = 0.06). Mean IgG-PT levels in males and females were 84 U/ml and 58.8 U/ml, respectively (P = 0.91).</p> <p>Conclusion</p> <p>A considerable proportion of our study population with a positive history of childhood vaccination for pertussis was not serologically immune to pertussis. A booster dose of acellular pertussis vaccine may be indicated in Iranian, medical students regarding their serologic conditions and outstanding role in health care systems.</p