SLC26A9 as a Potential Modifier and Therapeutic Target in Cystic Fibrosis Lung Disease

SLC26A9 belongs to the solute carrier family 26 (SLC26), which comprises membrane proteins involved in ion transport mechanisms. On the basis of different preliminary findings, including the phenotype of SlC26A9-deficient mice and its possible role as a gene modifier of the human phenotype and treatment response, SLC26A9 has emerged as one of the most interesting alternative targets for the treatment of cystic fibrosis (CF). However, despite relevant clues, some open issues and controversies remain. The lack of specific pharmacological modulators, the elusive expression reported in the airways, and its complex relationships with CFTR and the CF phenotype prevent us from conclusively understanding the contribution of SLC26A9 in human lung physiology and its real potential as a therapeutic target in CF. In this review, we summarized the various studies dealing with SLC26A9 expression, molecular structure, and function as an anion channel or transporter; its interaction and functional relationships with CFTR; and its role as a gene modifier and tried to reconcile them in order to highlight the current understanding and the gap in knowledge regarding the contribution of SLC26A9 to human lung physiology and CF disease and treatment

Unintentional and intentional recognition rely on dissociable neurocognitive mechanisms

Distractibility can lead to accidents and academic failures, as well as memory problems. Recent evidence suggests that intentional recognition memory can be biased by unintentional recognition of distracting stimuli in the same environment. It is unknown whether unintentional and intentional recognition depend on the same underlying neurocognitive mechanisms. We assessed whether human participants’ recognition of previously seen (old) or not seen (new) target stimuli was affected by whether a to-be-ignored distractor was old or new. ERPs were recorded to investigate the neural correlates of this bias. The results showed that the old/new status of salient distractors had a biasing effect on target recognition accuracy. Both intentional and unintentional recognition elicited early ERP effects that are thought to reflect relatively automatic memory processes. However, only intentional recognition elicited the later ERP marker of conscious recollection, consistent with previous suggestions that recollection is under voluntary control. In contrast, unintentional recognition was associated with an enhanced late posterior negativity, which may reflect monitoring or evaluation of memory signals. The findings suggest that unintentional and intentional recognition involve dissociable memory processes

Labeling of Activity Recognition Datasets: Detection of Misbehaving Users

Automatic recognition of user’s activities by means of wearable devices is a key element of many e-health applications, ranging from rehabilitation to monitoring of elderly citizens. Activity recognition methods generally rely on the availability of annotated training sets, where the traces collected using sensors are labelled with the real activity carried out by the user. We propose a method useful to automatically identify misbehaving users, i.e. the users that introduce inaccuracies during the labeling phase. The method is semi-supervised and detects misbehaving users as anomalies with respect to accurate ones. Experimental results show that misbehaving users can be detected with more than 99% accuracy

Dashboard Executive Information System Pada Banjar Berbasis Web

Teknologi komputer selalu berkembang sampai pada saat ini. Komputer biasanya digunakan untuk mencari hiburan, membuat riset, dan melakukan pekerjaan. Saat ini hampir semua komputer digunakan oleh Perusahaan-Perusahaan dalam melakukan pekerjaannya. Pengguna komputer dalam melakukan pekerjaannya dibantu dengan perangkat lunak sehingga dapat menyelesaikan pekerjaan dengan cepat. Di dalam sebuah banjar ketersediaan informasi dan kemampuan dalam mengolah data secara efektif merupakan keperluan yang sangat penting dalam organisasi karena keberhasilan dari suatu organisasi tergantung pada tersedianya informasi yang dibutuhkan dan bagaimana cara-cara pemenuhan kebutuhan informasi tersebut. Pada beberapa banjar sekarang sudah menggunakan sistem yang terkomputerisasi tetapi masih sangat sederhana. Dashboard Information system merupakan sistem informasi yang menampilkan data secara visual. Dengan menggunakan dashboard diharapkan dapat mempermudah dan membantu penampilan data-data yang ada pada banjar

The Post-Traumatic Stress Disorder Checklist for DSM-5: Psychometric Properties of the Italian Version

Background: The present study aimed to investigate the psychometric properties of the Italian version of the PTSD Checklist for the DSM-V (PCL-5) in a group of adults who had experienced heterogenous traumatic events. Methods: Six hundred and one participants met the inclusion criteria and completed a set of questionnaires through an online survey. Before administering the survey, the PCL-5 was translated into Italian according to the back-translation method. The factorial structure of the PCL-5 was assessed through multiple confirmatory factor analyses. Gender measurement invariance and concurrent and criterion validity were also evaluated. Results: The instrument had a seven-factor structure and it worked in a similar manner for males and females. With regard to the concurrent validity, results showed that higher PCL-5 scores were associated with higher levels of depression and rumination and lower levels of life satisfaction. Regarding criterion validity, results revealed that PCL-5 scores were, on average, higher for females than for males, and the temporal distance from the traumatic event was negatively correlated with the total PCL-5 score. Conclusions: The findings indicated that the Italian version of the PCL-5 was able to provide valid and reliable scores for the assessment of PTSD symptoms in the Italian population

Aluminium-26 production in low- and intermediate-mass binary systems

Aluminium-26 is a radioactive isotope which can be synthesized within asymptotic giant branch (AGB) stars, primarily through hot bottom burning. Studies exploring $^{26}$Al production within AGB stars typically focus on single-stars; however, observations show that low- and intermediate-mass stars commonly exist in binaries. We use the binary population synthesis code binary_c to explore the impact of binary evolution on $^{26}$Al yields at solar metallicity both within individual AGB stars and a low/intermediate-mass stellar population. We find the key stellar structural condition achieving most $^{26}$Al overproduction is for stars to enter the thermally-pulsing AGB (TP-AGB) phase with small cores relative to their total masses, allowing those stars to spend abnormally long times on the TP-AGB compared to single-stars of identical mass. Our population with a binary fraction of 0.75 has an $^{26}$Al weighted population yield increase of $25\%$ compared to our population of only single-stars. Stellar-models calculated from the Mt Stromlo/Monash Stellar Structure Program, which we use to test our results from binary_c and closely examine the interior structure of the overproducing stars, support our binary_c results only when the stellar envelope gains mass after core-He depletion. Stars which gain mass before core-He depletion still overproduce $^{26}$Al, but to a lesser extent. This introduces some physical uncertainty into our conclusions as $55\%$ of our $^{26}$Al overproducing stars gain envelope mass through stellar wind accretion onto pre-AGB objects. Our work highlights the need to consider binary influence on the production of $^{26}$Al.Comment: 20 pages, 17 figures, and 6 tables. This article has been accepted for publication in MNRAS Published by Oxford University Press on behalf of the Royal Astronomical Societ

Sickness presenteeism: measurement and management challenges

Since work can be restorative to health, attending work when unwell should not be viewed as an inherently negative phenomenon. However, the functional benefits are likely to depend on the health condition, and the psychosocial quality of the work provided. The current study used a workforce survey to explore differences in the pattern of presenteeism and absenteeism by health condition, the association of psychosocial work factors with presenteeism compared to absenteeism, and their interaction to predict health. Findings indicate that instead of substituting absenteeism for presenteeism, the two tend to coincide, but the balance differs by health condition. Presenteeism is more likely to occur in poorer psychosocial environments, reinforcing the importance of ensuring work is designed and managed in ways that are beneficial rather than detrimental to health. The findings also highlight the methodological importance of differentiating between the act and impact of presenteeism in future research and practice