Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer’s and Parkinson’s disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer's disease and Parkinson's disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition

spacetelescope/tweakwcs: Maintenance release: Improved compatibility with numpy 2.0. Minor bug fixes and improvements

Algorithms for matching and aligning catalogs and for tweaking the WCS so as to minimize catalog mismatch error

spacetelescope/tweakwcs: Package setup infrastructure reorganization.

<p>Package setup infrastructure reorganization. Python 3.12 compatibility improvements.</p&gt

spacetelescope/tweakwcs: Do not use failed to align images in refcat expansion. Improved 2dhist.

<p>Images that fail to align to the reference catalog when <code>expand_refcat</code> enabled will no longer be added to the reference catalog. [#195]</p> <p>Improved algorithm for initial shift estimation used in catalog matching (<code>2dhist</code>) reduces both memory usage and often processing speed. [#196]</p&gt

spacetelescope/pysiaf: Update to PRDOPSSOC-063

<p>This release updates the default JWST SIAF used in this package to PRDOPSSOC-063.</p&gt

spacetelescope/gwcs: GWCS v 0.20.0

<p><strong>Changes in GWCS 0.20.0</strong></p> <ul> <li>Replace pkg_resources with importlib.metadata. [#478]</li> <li>Serialize and deserialize pixel_shape with asdf. [#480]</li> </ul&gt

spacetelescope/drizzlepac: Drizzlepac v3.6.2 release candidate 1

<h2>High-level Summary</h2> <p>Follow on to Release Candidate 0.</p> <h2>What's Changed</h2> <ul> <li>Update code to update WPFC2 chip gaps by @stsci-hack in https://github.com/spacetelescope/drizzlepac/pull/1551</li> <li>HlA-1059: Reference catalog weights corrected by @s-goldman in https://github.com/spacetelescope/drizzlepac/pull/1616</li> <li>HLA-1052: Updated WFPC2 drizzle parameters for HAP by @s-goldman in https://github.com/spacetelescope/drizzlepac/pull/1617</li> <li>Fixed bug in calculation of the measurements for each detected source by @mdlpstsci in https://github.com/spacetelescope/drizzlepac/pull/1614</li> <li>HLA-1048: Redesign of readthedocs documentation by @s-goldman in https://github.com/spacetelescope/drizzlepac/pull/1620</li> <li>Drizzlepac: Ensure the "best" WCS solution is found when using a set by @mdlpstsci in https://github.com/spacetelescope/drizzlepac/pull/1638</li> <li>Correctly fix the wcs preferential order REL > IMG, GAIA*3 > GAIA[2|1] by @mdlpstsci in https://github.com/spacetelescope/drizzlepac/pull/1645</li> <li>drop support for Python 3.8 by @zacharyburnett in https://github.com/spacetelescope/drizzlepac/pull/1541</li> <li>Removed version restriction on Matplotlib by @mdlpstsci in https://github.com/spacetelescope/drizzlepac/pull/1649</li> <li>Allow group specifications as integers or tuples by @mcara in https://github.com/spacetelescope/drizzlepac/pull/1612</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/spacetelescope/drizzlepac/compare/3.6.1...3.6.2rc1</p&gt

spacetelescope/drizzlepac: Drizzlepac v3.6.2 release candidate 3

<h2>High-level Summary</h2> <p>Follow on to Release Candidate 0, 1, and 2.</p> <h2>What's Changed</h2> <ul> <li>HLA-1150: MVM failure due to HAPProduct constructor mismatch by @s-goldman in https://github.com/spacetelescope/drizzlepac/pull/1693</li> </ul&gt