Development of a novel DDS for site-specific PEGylated proteins

Because of the shifted focus in life science research from genome analyses to genetic and protein function analyses, we now know functions of numerous proteins. These analyses, including those of newly identified proteins, are expected to contribute to the identification of proteins of therapeutic value in various diseases. Consequently, pharmacoproteomic-based drug discovery and development of protein therapies attracted a great deal of attention in recent years. Clinical applications of most of these proteins are, however, limited because of their unexpectedly low therapeutic effects, resulting from the proteolytic degradation in vivo followed by rapid removal from the circulatory system. Therefore, frequent administration of excessively high dose of a protein is required to observe its therapeutic effect in vivo. This often results in impaired homeostasis in vivo and leads to severe adverse effects. To overcome these problems, we have devised a method for chemical modification of proteins with polyethylene glycol (PEGylation) and other water-soluble polymers. In addition, we have established a method for creating functional mutant proteins (muteins) with desired properties, and developed a site-specific polymer-conjugation method to further improve their therapeutic potency. In this review, we are introducing our original protein-drug innovation system mentioned above

Identifying gravity waves launched by the Hunga Tonga-Hunga Ha‘apai volcanic eruption in mesosphere/lower thermosphere winds derived from CONDOR and the Nordic Meteor Radar Cluster

The Hunga Tonga-Hunga Ha‘apai volcano eruption was a unique event that caused many atmospheric phenomena around the globe. In this study, we investigate the atmospheric gravity waves in the mesosphere/lower thermosphere (MLT) launched by the volcanic explosion in the Pacific leveraging multistatic meteor radar observations from the Chilean Observation Network De Meteor Radars (CONDOR) and the Nordic Meteor Radar Cluster in Fennoscandia. MLT winds are computed using a recently developed 3DVAR+DIV algorithm. We found an eastward and a westward traveling gravity wave in the CONDOR zonal and meridional wind measurements, which arrived 12 hours and 48 hours after the eruption, and one in Nordic Meteor Radar Cluster that arrived 27.5 hours after the volcanic detonation. We obtained observed phase speeds for the eastward great circle path at both locations of about 250 m/s and 170–150 m/s for the opposite propagation direction. The intrinsic phase speed was estimated to be 200–212 m/s. Furthermore, we identified a potential lamb wave signature in the MLT winds using 5 minute resolved 3DVAR+DIV retrievals

Atmospheric Tomography Using the Nordic Meteor Radar Cluster And Chilean Observation Network de Meteor Radars: Network Details and 3D-Var Retrieval

Ground-based remote sensing of atmospheric parameters is often limited to single station observations by vertical profiles at a certain geographic location. This is a limiting factor for investigating gravity wave dynamics as the spatial information is often missing, e.g., horizontal wavelength, propagation direction or intrinsic frequency. In this study, we present a new retrieval algorithm for multistatic meteor radar networks to obtain tomographic 3-D wind fields within a pre-defined domain area. The algorithm is part of the Agile Software for Gravity wAve Regional Dynamics (ASGARD) and called 3D-Var, and based on the optimal estimation technique and Bayesian statistics. The performance of the 3D-Var retrieval is demonstrated using two meteor radar networks: the Nordic Meteor Radar Cluster and the Chilean Observation Network De Meteor Radars (CONDOR). The optimal estimation implementation provide statistically sound solutions and diagnostics from the averaging kernels and measurement response. We present initial scientific results such as body forces of breaking gravity waves leading to two counter-rotating vortices and horizontal wavelength spectra indicating a transition between the rotational k-3 and divergent k-5/3 mode at scales of 80–120 km. In addition, we performed a keogram analysis over extended periods to reflect the latitudinal and temporal impact of a minor sudden stratospheric warming in December 2019. Finally, we demonstrate the applicability of the 3D-Var algorithm to perform large-scale retrievals to derive meteorological wind maps covering a latitude region from Svalbard, north of the European Arctic mainland, to central Norway

Evolution of edge states in topological superfluids during the quantum phase transition

The quantum phase transition between topological and non-topological insulators or between fully gapped superfluids/superconductors can occur without closing the gap. We consider the evolution of the Majorana edge states on the surface of topological superconductor during transition to the topologically trivial superconductor on example of non-interacting Hamiltonian describing the spin-triplet superfluid 3He-B. In conventional situation when the gap is nullified at the transition, the spectrum of Majorana fermions shrinks and vanishes after the transition to the trivial state. If the topological transition occurs without the gap closing, the Majorana fermion spectrum disappears by escaping to ultraviolet, where Green's function approaches zero. This demonstrates the close connection between the topological transition without closing the gap and zeroes in the Green's function. Similar connection takes place in interacting systems where zeroes may occur due to interaction.Comment: 5 pages, 2 figures, JETP Letters style, version submitted to JETP Letter

Synthesis of Mesoporous Silica@Co–Al Layered Double Hydroxide Spheres: Layer-by-Layer Method and Their Effects on the Flame Retardancy of Epoxy Resins

Hierarchical mesoporous silica@Co–Al layered double hydroxide (m-SiO2@Co–Al LDH) spheres were prepared through a layer-by-layer assembly process, in order to integrate their excellent physical and chemical functionalities. TEM results depicted that, due to the electrostatic potential difference between m-SiO2 and Co–Al LDH, the synthetic m-SiO2@Co–Al LDH hybrids exhibited that m-SiO2 spheres were packaged by the Co–Al LDH nanosheets. Subsequently, the m-SiO2@Co–Al LDH spheres were incorporated into epoxy resin (EP) to prepare specimens for investigation of their flame-retardant performance. Cone results indicated that m-SiO2@Co–Al LDH incorporated obviously improved fire retardant of EP. A plausible mechanism of fire retardant was hypothesized based on the analyses of thermal conductivity, char residues, and pyrolysis fragments. Labyrinth effect of m-SiO2 and formation of graphitized carbon char catalyzed by Co–Al LDH play pivotal roles in the flame retardance enhancement

Flat bands in topological media

Topological media are systems whose properties are protected by topology and thus are robust to deformations of the system. In topological insulators and superconductors the bulk-surface and bulk-vortex correspondence gives rise to the gapless Weyl, Dirac or Majorana fermions on the surface of the system and inside vortex cores. Here we show that in gapless topological media, the bulk-surface and bulk-vortex correspondence is more effective: it produces topologically protected gapless fermions without dispersion -- the flat band. Fermion zero modes forming the flat band are localized on the surface of topological media with protected nodal lines and in the vortex core in systems with topologically protected Fermi points (Weyl points). Flat band has an extremely singular density of states, and we show that this property may give rise in particular to surface superconductivity which could exist even at room temperature.Comment: 9 pages, 5 figures, version to appear in JETP Letter

Identifying gravity waves launched by the Hunga Tonga–Hunga Ha′apai volcanic eruption in mesosphere/lower-thermosphere winds derived from CONDOR and the Nordic Meteor Radar Cluster

The Hunga Tonga–Hunga Ha′apai volcano eruption was a unique event that caused many atmospheric phenomena around the globe. In this study, we investigate the atmospheric gravity waves in the mesosphere/lower-thermosphere (MLT) launched by the volcanic explosion in the Pacific, leveraging multistatic meteor radar observations from the Chilean Observation Network De Meteor Radars (CONDOR) and the Nordic Meteor Radar Cluster in Fennoscandia. MLT winds are computed using a recently developed 3DVAR+DIV algorithm. We found eastward- and westward-traveling gravity waves in the CONDOR zonal and meridional wind measurements, which arrived 12 and 48 h after the eruption, and we found one in the Nordic Meteor Radar Cluster that arrived 27.5 h after the volcanic detonation. We obtained observed phase speeds for the eastward great circle path at both locations of about 250 m s−1, and they were 170–150 m s−1 for the opposite propagation direction. The intrinsic phase speed was estimated to be 200–212 m s−1. Furthermore, we identified a potential lamb wave signature in the MLT winds using 5 min resolved 3DVAR+DIV retrievals.</p