Correlation coefficients and partial correlation coefficients between variables.

<p>Correlation coefficients and partial correlation coefficients between variables.</p

Relationship between pharmacokinetic parameters of paritaprevir and CEI 20 (A, D); FIB-4 index (B, E); and serum albumin concentration (C) in all patients and relationship between trough concentration of paritaprevir and CEI 20 in cirrhotic patients (F).

<p>Black triangle, patients without hyperbilirubinemia; open triangle, patients with hyperbilirubinemia. AUC_0–6h, area under the blood concentration–time curve 0–6 h; CEI 20, contrast enhancement index at 20 min; C_trough, trough concentration.</p

Multivariate regression analysis predicting hyperbilirubinemia.

<p>Multivariate regression analysis predicting hyperbilirubinemia.</p

ROC curve analysis of each baseline parameter and prediction of hyperbilirubinemia.

<p>ROC curve analysis of each baseline parameter and prediction of hyperbilirubinemia.</p

Individual time course of serum bilirubin concentration in seven patients treated with paritaprevir who developed hyperbilirubinemia (≥ 1.6 mg/dl).

<p>Black line, total bilirubin; gray dotted line, direct bilirubin.</p

Correlation coefficients and partial correlation coefficients between variables.

<p>Correlation coefficients and partial correlation coefficients between variables.</p

Time profile of plasma paritaprevir concentration 7 d after the start of treatment in each patient (trough concentration, concentration at 2 h, 4 h, and 6 h after dosing).

<p>Gray line, patients without hyperbilirubinemia (N = 20); black dotted line, patients with hyperbilirubinemia (N = 7).</p

Variables in patients without and with hyperbilirubinemia before and during treatment.

<p>Variables in patients without and with hyperbilirubinemia before and during treatment.</p