Atorvastatin effectiveness in dyslipidemia correction among coronary heart disease and arterial hypertension patients with high risk of cardiovascular complications

Aim. To study the Russian atorvastatin generic (Liptonorm) effects on lipid metabolism in patients with coronary heart disease (CHD), essential arterial hypertension (EAH), and high risk of cardiovascular complications (CVC). Material and methods. In total, 30 patients (17 men, 13 women; mean age 52,37 years) with CHD (n=21), EAH (n=9), and high CVC risk were examined. Plasma levels of total cholesterol (TCH) were >5,2 mmol/l, low‑density lipoprotein CH, LDL‑CH ‑ >3,0 mmol/l. Lipid metabolism parameters and transaminase levels were measured at baseline, as well as after 2 and 4 weeks of Liptonorm treatment (10 mg/d). Results. After 4 weeks of the therapy, TCH and LDL‑CH levels were significantly reduced, by 22% from the baseline. Triglycerides (TG) concentration decreased to a lesser extent (8,8%); high‑density lipoprotein CH (HDL‑CH) and transaminase levels remained the same. Conclusion. Four‑week therapy with the Russian medication Liptonorm (10 mg/d) significantly reduced TCH, LDL‑CH levels, decreased TG concentration, without affecting HDL‑CH level. Liptonorm was safe, well tolerated, without any serious adverse effects. Patients ioetns regarded Lipronotm therapy regimen as “convenient”, that might increase their therapy compliance. Moreover, 90% of the patients regarded the medication price as “adequate” for their income levels

Carvedilol therapy effects on structural and electric remodeling in chronic heart failure

Aim. To assess the effects of combination therapy with ACE inhibitors and carvedilol on cardiac remodeling, cardiac arrhythmias, and quality of life (QoL) in patients with mild to moderate chronic heart failure (CHF).Material and methods. The study included 109 patients with mild to moderate CHF, developed in arterial hypertension, coronary heart disease, or their combination with diabetes mellitus and obesity. Initial carvedilol dose was 6,25-25 mg/d. At baseline, 3, 6, and 9 months later, physical examination, biochemical assay,  lectrocardiography,QoL and clinical outcome assessment were performed. Doppler echocardiography and 24-hour electrocardiogram (ECG) monitoring were performed at baseline and 6 months later.Results. CHF therapy, including the combination of ACE inhibitor and carvedilol, was associated with reduction in structural left ventricular (LV) remodeling, as well as with systolic and diastolic LV function normalization. According to 24-hour ECG monitoring data, the total number of supraventricular (including paired and grouped) and ventricular (including paired ectopic complexes) extrasystoles significantly decreased. Combination, carvedilol-including CHF therapy resulted in significant QoL and clinical prognosis improvement.Conclusion. In patients with mild to moderate CHF, carvedilol demonstrated its clinical effectiveness, including reduced structural and electric remodeling progression