First detection of GeV emission from an ultraluminous infrared galaxy: Arp 220 as seen with the Fermi Large Area Telescope

Cosmic rays (CRs) in starburst galaxies produce high energy gamma-rays by colliding with the dense interstellar medium (ISM). Arp 220 is the nearest ultra luminous infrared galaxy (ULIRG) that has star-formation at extreme levels, so it has long been predicted to emit high-energy gamma-rays. However, no evidence of gamma-ray emission was found despite intense efforts of search. Here we report the discovery of high-energy gamma-ray emission above 200 MeV from Arp 220 at a confidence level of $\sim 6.3 \sigma$ using 7.5 years of \textsl {Fermi} Large Area Telescope observations. The gamma-ray emission shows no significant variability over the observation period and it is consistent with the quasi-linear scaling relation between the gamma-ray luminosity and total infrared luminosity for star-forming galaxies, suggesting that these gamma-rays arise from CR interactions. As the high density medium of Arp 220 makes it an ideal CR calorimeter, the gamma-ray luminosity can be used to measure the efficiency of powering CRs by supernova (SN) remnants given a known supernova rate in Arp 220. We find that this efficiency is about $4.2\pm2.6\%$ for CRs above 1 GeV.Comment: Accepted by ApJL, 6 pages, 3 figure

Evidence of a spectral break in the gamma-ray emission of the disk component of Large Magellanic Cloud: a hadronic origin?

It has been suggested that high-energy gamma-ray emission ($>100{\rm MeV}$) of nearby star-forming galaxies may be produced predominantly by cosmic rays colliding with the interstellar medium through neutral pion decay. The pion-decay mechanism predicts a unique spectral signature in the gamma-ray spectrum, characterized by a fast rising spectrum and a spectral break below a few hundreds of MeV. We here report the evidence of a spectral break around 500 MeV in the disk emission of Large Magellanic Cloud (LMC), which is found in the analysis of the gamma-ray data extending down to 60 MeV observed by {\it Fermi}-Large Area Telescope. The break is well consistent with the pion-decay model for the gamma-ray emission, although leptonic models, such as the electron bremsstrahlung emission, cannot be ruled out completely.Comment: 11 pages, 4 figures, Accepted by Ap

Detection of gamma-ray emission from the Coma cluster with Fermi Large Area Telescope and tentative evidence for an extended spatial structure

Many galaxy clusters have giant halos of non-thermal radio emission, indicating the presence of relativistic electrons in the clusters. Relativistic protons may also be accelerated by merger and/or accretion shocks in galaxy clusters. These cosmic-ray (CR) electrons and/or protons are expected to produce gamma-rays through inverse-Compton scatterings or inelastic $pp$ collisions respectively. Despite of intense efforts in searching for high-energy gamma-ray emission from galaxy clusters, conclusive evidence is still missing so far. Here we report the discovery of $\ge 200$ MeV gamma-ray emission from the Coma cluster direction with an unbinned likelihood analysis of the 9 years of {\it Fermi}-LAT Pass 8 data. The gamma-ray emission shows a spatial morphology roughly coincident with the giant radio halo, with an apparent excess at the southwest of the cluster. Using the test statistic analysis, we further find tentative evidence that the gamma-ray emission at the Coma center is spatially extended. The extended component has an integral energy flux of $\sim 2\times 10^{-12}{\rm \ erg\ cm^{-2}\ s^{-1}}$ in the energy range of 0.2 - 300 GeV and the spectrum is soft with a photon index of $\simeq-2.7$. Interpreting the gamma-ray emission as arising from CR proton interaction, we find that the volume-averaged value of the CR to thermal pressure ratio in the Coma cluster is about $\sim 2\%$. Our results show that galaxy clusters are likely a new type of GeV gamma-ray sources, and they are probably also giant reservoirs of CR protons.Comment: 10 pages, 10 figures, Accepted by Physical Review D, more spatial models for the gamma-ray emission are used, systematic checks on the results are adde

Implication of GRB 221009A: Can TeV Emission Come from the GRB Prompt Phase?

Recently, the B.O.A.T. ("brightest of all time") gamma-ray burst, dubbed GRB 221009A, was detected by various instruments. Unprecedentedly, the GRB presented very-high-energy (VHE, energy above 0.1 TeV) gamma-ray emission with energy extending above 10 TeV, as reported by the Large High Altitude Air Shower Observatory (LHAASO). We here demonstrate that the VHE and especially >10 TeV emission may originate from the internal hadronic dissipation of the GRB, without the need of invoking any exotic processes as suggested by some previous studies. We also discuss the constraints on the properties of the GRB ejecta from multiwavelength and multi-messenger observations, which favors a magnetically dominated GRB ejecta. The suggested Poynting-flux-dominated GRB ejecta in this work supports the Blandford & Znajek (BZ) mechanism as the possible central engine model of GRB.Comment: 13 pages, 7 figures, 3 tables, accepted versio

Modeling the broadband emission of Fermi/LAT GRB 090902B

GRB 090902B, detected by Fermi Large Array Telescope (Fermi/LAT), shows extend high-energy emission (>100 MeV) up to 10^3 s after the burst, which decays with time in a power-law as t^{-1.5}. It has been also observed by several follow-up low-energy instruments, including an early optical detection around 5000 s after the burst. The optical emission at early time decays faster than t^{-1.6}, which has been suspected to originate from the reverse shock. We here explore the models that can possibly explain the the broadband afterglow emission of GRB 090902B. We find that the reverse shock model for the early optical emission would overpredict the radio afterglow flux that is inconsistent with observations. A partially radiative blast wave model, which though is able to produce a sufficiently steep decay slope, can not explain the broadband data of GRB 090902B. The two-component jet model, which consists of a narrow and bright jet component in the core and a surrounding wider and less energetic jet component, is shown to be able to explain the broadband afterglow data, including the LAT high-energy data after ~50 s and low-energy (radio, optical and X-ray) afterglow data. The early-time high-energy emission detected by LAT before ~50 s is likely due to internal origin as that of the sub-MeV emission. The highest energy (33 GeV) photon of GRB090902B detected at 80 s can be marginally accommodated within the forward shock emission under the optimistic condition that electrons are accelerated by the Bohm diffusive shock.Comment: Accepted for publication in ApJ (minor changes, references updated), 11 pages (emulateapj style), 4 figure

Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice.

Rhein, a component derived from rhubarb, has been proven to possess anti-inflammatory properties. Here, we show that rhein mitigates obesity by promoting adipose tissue thermogenesis in diet-induced obese mice. We construct a macrophage-adipocyte co-culture system and demonstrate that rhein promotes adipocyte thermogenesis through inhibiting NLRP3 inflammasome activation in macrophages. Moreover, clues from acetylome analysis identify SIRT2 as a potential drug target of rhein. We further verify that rhein directly interacts with SIRT2 and inhibits NLRP3 inflammasome activation in a SIRT2-dependent way. Myeloid knockdown of SIRT2 abrogates adipose tissue thermogenesis and metabolic benefits in obese mice induced by rhein. Together, our findings elucidate that rhein inhibits NLRP3 inflammasome activation in macrophages by regulating SIRT2, and thus promotes white adipose tissue thermogenesis during obesity. These findings uncover the molecular mechanism underlying the anti-inflammatory and anti-obesity effects of rhein, and suggest that rhein may become a potential drug for treating obesity

Experimental evidence for Berry curvature multipoles in antiferromagnets

Berry curvature multipoles appearing in topological quantum materials have recently attracted much attention. Their presence can manifest in novel phenomena, such as nonlinear anomalous Hall effects (NLAHE). The notion of Berry curvature multipoles extends our understanding of Berry curvature effects on the material properties. Hence, research on this subject is of fundamental importance and may also enable future applications in energy harvesting and high-frequency technology. It was shown that a Berry curvature dipole can give rise to a 2nd order NLAHE in materials of low crystalline symmetry. Here, we demonstrate a fundamentally new mechanism for Berry curvature multipoles in antiferromagnets that are supported by the underlying magnetic symmetries. Carrying out electric transport measurements on the kagome antiferromagnet FeSn, we observe a 3rd order NLAHE, which appears as a transverse voltage response at the 3rd harmonic frequency when a longitudinal a.c. current drive is applied. Interestingly, this NLAHE is strongest at and above room temperature. We combine these measurements with a scaling law analysis, a symmetry analysis, model calculations, first-principle calculations, and magnetic Monte-Carlo simulations to show that the observed NLAHE is induced by a Berry curvature quadrupole appearing in the spin-canted state of FeSn. At a practical level, our study establishes NLAHE as a sensitive probe of antiferromagnetic phase transitions in other materials, such as moir\'e superlattices, two-dimensional van der Waal magnets, and quantum spin liquid candidates, that remain poorly understood to date. More broadly, Berry curvature multipole effects are predicted to exist for 90 magnetic point groups. Hence, our work opens a new research area to study a variety of topological magnetic materials through nonlinear measurement protocols

Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth

Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacological inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity and other diseases. Here we report a previously unknown mechanism of FASN regulation involving its acetylation by KAT8 and its deacetylation by HDAC3. FASN acetylation promoted its degradation via the ubiquitin-proteasome pathway. FASN acetylation enhanced its association with the E3 ubiquitin-ligase TRIM21. Acetylation destabilized FASN and resulted in decreased de novo lipogenesis and tumor cell growth. FASN acetylation was frequently reduced in human hepatocellular carcinoma samples, which correlated with increased HDAC3 expression and FASN protein levels. Our results suggest opportunities to target FASN acetylation as an anticancer strategy

Dual-comb spectroscopy over 100km open-air path

Satellite-based greenhouse gases (GHG) sensing technologies play a critical role in the study of global carbon emissions and climate change. However, none of the existing satellite-based GHG sensing technologies can achieve the measurement of broad bandwidth, high temporal-spatial resolution, and high sensitivity at the same time. Recently, dual-comb spectroscopy (DCS) has been proposed as a superior candidate technology for GHG sensing because it can measure broadband spectra with high temporal-spatial resolution and high sensitivity. The main barrier to DCS's display on satellites is its short measurement distance in open air achieved thus far. Prior research has not been able to implement DCS over 20 km of open-air path. Here, by developing a bistatic setup using time-frequency dissemination and high-power optical frequency combs, we have implemented DCS over a 113 km turbulent horizontal open-air path. Our experiment successfully measured GHG with 7 nm spectral bandwidth and a 10 kHz frequency and achieved a CO2 sensing precision of <2 ppm in 5 minutes and <0.6 ppm in 36 minutes. Our results represent a significant step towards advancing the implementation of DCS as a satellite-based technology and improving technologies for GHG monitoringComment: 24 pages, 6 figure

Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy

Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered. Fuzi, the lateral roots of Aconitum carmichaelii, shows unique efficacy in reviving Yang for resuscitation, which has been widely used in clinics. As a main cardiotonic component of Fuzi, mesaconine has been proven effective in various cardiomyopathy models. Here, we aimed to define a previously unrevealed cardioprotective mechanism of mesaconine-mediated restoration of obstructive mitophagy. The functional implications of mesaconine were evaluated in doxorubicin (DOX)-induced heart failure models. DOX-treated mice showed characteristic cardiac dysfunction, ectopic myocardial energy disorder, and impaired mitophagy in cardiomyocytes, which could be remarkably reversed by mesaconine. The cardioprotective effect of mesaconine was primarily attributed to its ability to promote the restoration of mitophagy in cardiomyocytes, as evidenced by elevated expression of PINK1, a key mediator of mitophagy induction. Silencing PINK1 or deactivating mitophagy could completely abolish the protective effects of mesaconine. Together, our findings suggest that the cardioprotective effects of mesaconine appear to be dependent on the activation of PINK1-induced mitophagy and that mesaconine may constitute a promising therapeutic agent for the treatment of heart failure