16 research outputs found
Argo data 1999-2019: two million temperature-salinity profiles and subsurface velocity observations from a global array of profiling floats.
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Wong, A. P. S., Wijffels, S. E., Riser, S. C., Pouliquen, S., Hosoda, S., Roemmich, D., Gilson, J., Johnson, G. C., Martini, K., Murphy, D. J., Scanderbeg, M., Bhaskar, T. V. S. U., Buck, J. J. H., Merceur, F., Carval, T., Maze, G., Cabanes, C., Andre, X., Poffa, N., Yashayaev, I., Barker, P. M., Guinehut, S., Belbeoch, M., Ignaszewski, M., Baringer, M. O., Schmid, C., Lyman, J. M., McTaggart, K. E., Purkey, S. G., Zilberman, N., Alkire, M. B., Swift, D., Owens, W. B., Jayne, S. R., Hersh, C., Robbins, P., West-Mack, D., Bahr, F., Yoshida, S., Sutton, P. J. H., Cancouet, R., Coatanoan, C., Dobbler, D., Juan, A. G., Gourrion, J., Kolodziejczyk, N., Bernard, V., Bourles, B., Claustre, H., D'Ortenzio, F., Le Reste, S., Le Traon, P., Rannou, J., Saout-Grit, C., Speich, S., Thierry, V., Verbrugge, N., Angel-Benavides, I. M., Klein, B., Notarstefano, G., Poulain, P., Velez-Belchi, P., Suga, T., Ando, K., Iwasaska, N., Kobayashi, T., Masuda, S., Oka, E., Sato, K., Nakamura, T., Sato, K., Takatsuki, Y., Yoshida, T., Cowley, R., Lovell, J. L., Oke, P. R., van Wijk, E. M., Carse, F., Donnelly, M., Gould, W. J., Gowers, K., King, B. A., Loch, S. G., Mowat, M., Turton, J., Rama Rao, E. P., Ravichandran, M., Freeland, H. J., Gaboury, I., Gilbert, D., Greenan, B. J. W., Ouellet, M., Ross, T., Tran, A., Dong, M., Liu, Z., Xu, J., Kang, K., Jo, H., Kim, S., & Park, H. Argo data 1999-2019: two million temperature-salinity profiles and subsurface velocity observations from a global array of profiling floats. Frontiers in Marine Science, 7, (2020): 700, doi:10.3389/fmars.2020.00700.In the past two decades, the Argo Program has collected, processed, and distributed over two million vertical profiles of temperature and salinity from the upper two kilometers of the global ocean. A similar number of subsurface velocity observations near 1,000 dbar have also been collected. This paper recounts the history of the global Argo Program, from its aspiration arising out of the World Ocean Circulation Experiment, to the development and implementation of its instrumentation and telecommunication systems, and the various technical problems encountered. We describe the Argo data system and its quality control procedures, and the gradual changes in the vertical resolution and spatial coverage of Argo data from 1999 to 2019. The accuracies of the float data have been assessed by comparison with high-quality shipboard measurements, and are concluded to be 0.002°C for temperature, 2.4 dbar for pressure, and 0.01 PSS-78 for salinity, after delayed-mode adjustments. Finally, the challenges faced by the vision of an expanding Argo Program beyond 2020 are discussed.AW, SR, and other scientists at the University of Washington (UW) were supported by the US Argo Program through the NOAA Grant NA15OAR4320063 to the Joint Institute for the Study of the Atmosphere and Ocean (JISAO) at the UW. SW and other scientists at the Woods Hole Oceanographic Institution (WHOI) were supported by the US Argo Program through the NOAA Grant NA19OAR4320074 (CINAR/WHOI Argo). The Scripps Institution of Oceanography's role in Argo was supported by the US Argo Program through the NOAA Grant NA15OAR4320071 (CIMEC). Euro-Argo scientists were supported by the Monitoring the Oceans and Climate Change with Argo (MOCCA) project, under the Grant Agreement EASME/EMFF/2015/1.2.1.1/SI2.709624 for the European Commission
Effect of the Higher Sampling Rate of Perturbation-and-Observation Control in Photovoltaic Systems Installed on Roofs and Cars
脳出血後遺症における塩酸テラゾシン(バソメット(R))の舌下投与時の血漿中薬物動態
雑誌掲載版脳出血後遺症の患者4例に塩酸テラゾシン0.5 mg錠の舌下投与を行った.1)塩酸テラゾシンは舌下投与により,速やかに吸収され,投与2時間後に最高血漿中濃度に達した.血漿中半減期はt1/2α 1.5時間,t1/2β 14.9時間であり,経口投与とほぼ同等であった.2)血圧は拡張期血圧の有意な下降が認められた.3)副作用,臨床検査値異常は特に認められなかっ
Chemical Synthesis of Homogeneous Human Glycosyl-interferon-β That Exhibits Potent Antitumor Activity in Vivo
Chemical synthesis of homogeneous human glycoproteins
exhibiting
bioactivity in vivo has been a challenging task. In an effort to overcome
this long-standing problem, we selected interferon-β and examined
its synthesis. The 166 residue polypeptide chain of interferon-β
was prepared by covalent condensation of two synthetic peptide segments
and a glycosylated synthetic peptide bearing a complex-type glycan
of biological origin. The peptides were covalently condensed by native
chemical ligation. Selective desulfurization followed by deprotection
of the two Cys(Acm) residues gave the target full-length polypeptide
chain of interferon-β bearing either a complex-type sialyl biantennary
oligosaccharide or its asialo form. Subsequent folding with concomitant
formation of the native disulfide bond afforded correctly folded homogeneous
glycosyl-interferon-β. The chemically synthesized sialyl interferon-β
exhibited potent antitumor activity in vivo
Endoscopic submucosal tunnel dissection versus conventional endoscopic submucosal dissection for early gastric cancers: outcomes of 799 consecutive cases in a single institution
Zonisamide(ZNS)の抗てんかん作用についての基礎的研究
雑誌掲載版カイニン酸誘発てんかんモデルを用いて基礎的な検討をおこなった。実験1では,ネコの急性実験で,脳波によるZNSの抗てんかん作用を検討するとともに,海馬の血流変化を熱勾配式組織血流計および電解式水素クリアランス法にて測定し,抗てんかん薬の基礎的な薬理作用について検討した。カイニン酸の扁桃核内注入により辺縁系発作重積を誘発し,ZNSを投与しその効果を検討した。ZNSの脳波上での抗てんかん作用は,辺縁系発作の皮質への伝播を抑制することを明らかにした。投与直後より背測海馬の局所脳血流量を2時間以上にわたって増加させた。実験2では,ラットの辺縁系発作に及ぼすZNSの影響について発作時脳波および行動の検討をおこない,辺縁系発作の抑制が認められたことよりZNSの発作抑制の有効性を確認し