Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Purpose The aim of this study was to describe the characteristics of epilepsy in cerebral palsy (CP) patients and identify risk factors for epilepsy and drug-resistant epilepsy. Methods CP patients aged 18 years old or younger who visited the pediatric neurology department and/or rehabilitation department of a tertiary care hospital between January 2016 and December 2022 with a minimum follow-up period of 2 years were included. Demographic and clinical data, seizure characteristics, brain imaging, electroencephalography, and genetic evaluation results were reviewed retrospectively. Results Among 268 patients included in this study, 36.9% had epilepsy and 10.8% had drug-resistant epilepsy. Asphyxia (29.3%), hemorrhage, infarction, and brain infection (25.3%) were associated with epilepsy. Epileptic CP patients were more likely to experience neonatal seizures (18.2% vs. 4.1%, P<0.001) and febrile seizures (12.1% vs. 7.1%, P=0.02) than non-epilepsy CP patients. The most common cerebral subtype in patients with epilepsy was spastic quadriplegia (59.6%). Epilepsy patients were more severely impaired in gross motor function, with worse intellectual disability. Patients with macrocephaly or cerebral malformation were more likely to have drug resistance. Valproate (51.7% and 25.7%) and levetiracetam (41.4% and 25.7%) were the two most commonly used antiseizure medications, both in monotherapy and polytherapy. Conclusion A history of asphyxia, febrile seizure, neonatal seizure, spastic quadriplegia, more severely impaired gross motor function, and intellectual disability were found to be risk factors for epilepsy. Further research with prospective data collection to develop a model for predicting seizures or epilepsy in CP patients is needed

Large-scale filamentary structures around the Virgo cluster revisited

We revisit the filamentary structures of galaxies around the Virgo cluster, exploiting a larger dataset based on the HyperLeda database than previous studies. In particular, this includes a large number of low-luminosity galaxies, resulting in better sampled individual structures. We confirm seven known structures in the distance range 4~$h^{-1}$~Mpc~$<$ SGY~$<$ 16~$h^{-1}$ Mpc, now identified as filaments, where SGY is the axis of the supergalactic coordinate system roughly along the line of sight. The Hubble diagram of the filament galaxies suggests they are infalling toward the main-body of the Virgo cluster. We propose that the collinear distribution of giant elliptical galaxies along the fundamental axis of the Virgo cluster is smoothly connected to two of these filaments (Leo~II~A and B). Behind the Virgo cluster (16~$h^{-1}$~Mpc~$<$ SGY~$<$ 27~$h^{-1}$~Mpc), we also identify a new filament elongated toward the NGC 5353/4 group ("NGC 5353/4 filament") and confirm a sheet that includes galaxies from the W and M clouds of the Virgo cluster ("W-M sheet"). In the Hubble diagram, the NGC 5353/4 filament galaxies show infall toward the NGC 5353/4 group, whereas the W-M sheet galaxies do not show hints of gravitational influence from the Virgo cluster. The filamentary structures identified can now be used to better understand the generic role of filaments in the build-up of galaxy clusters at z~$\approx$~0.Comment: 8 pages, 4 figures, accepted for publication in Ap

Observations of cold extragalactic gas clouds at z=0.45z = 0.45 towards PKS 1610-771

We present results from MUSE observations of a 21-cm HI absorption system detected with the Australian Square Kilometre Array Pathfinder radio telescope at redshift $z = 0.4503$ towards the $z = 1.71$ quasar PKS 1610-771. We identify four galaxies (A, B, X and Y) at the same redshift as the 21-cm H I Damped Lyman-{\alpha} (DLA) absorption system, with impact parameters ranging from less than 10 kpc to almost 200 kpc from the quasar sightline. Ca II and Na I absorption is seen in the MUSE spectrum of the background QSO, with velocities coinciding with the initial HI 21-cm detection, but tracing less dense and warmer gas. This metal-line component aligns with the rotating ionised disc of galaxy B (impact parameter 18 kpc from the QSO) and appears to be co-rotating with the galaxy disc. In contrast, the 21-cm HI absorber is blueshifted relative to the galaxies nearest the absorber and has the opposite sign to the velocity field of galaxy B. Since galaxies A and B are separated by only 17 kpc on the sky and $70$ km s$^{-1}$ in velocity, it appears likely that the 21-cm detection traces extragalactic clouds of gas formed from their interaction. This system reveals that the cold 100 K neutral gas critical for star formation can be associated with complex structures beyond the galaxy disc, and is a first case study made in preparation for future large 21-cm absorption surveys like the ASKAP First Large Absorption Survey in HI.Comment: Accepted. 13 pages, 7 figure

FAST discovery of a fast neutral hydrogen outflow

In this letter, we report the discovery of a fast neutral hydrogen outflow in SDSS J145239.38+062738.0, a merging radio galaxy containing an optical type I active galactic nuclei (AGN). This discovery was made through observations conducted by the Five-hundred-meter Aperture Spherical radio Telescope (FAST) using redshifted 21-cm absorption. The outflow exhibits a blueshifted velocity likely up to $\sim-1000\,\rm km\,s^{-1}$ with respect to the systemic velocity of the host galaxy with an absorption strength of $\sim -0.6\,\rm mJy\,beam^{-1}$ corresponding to an optical depth of 0.002 at $v=-500\,\rm km\,s^{-1}$. The mass outflow rate ranges between $2.8\times10^{-2}$ and $3.6\, \rm M_\odot \, yr^{-1}$, implying an energy outflow rate ranging between $4.2\times10^{39}$ and $9.7\times10^{40}\rm\,erg\,s^{-1}$, assuming 100 K $<T_{\rm s}<$ 1000 K. Plausible drivers of the outflow include the star bursts, the AGN radiation, and the radio jet, the last of which is considered the most likely culprit according to the kinematics. By analysing the properties of the outflow, the AGN, and the jet, we find that if the HI outflow is driven by the AGN radiation, the AGN radiation seems not powerful enough to provide negative feedback whereas the radio jet shows the potential to provide negative feedback. Our observations contribute another example of a fast outflow detected in neutral hydrogen, as well as demonstrate the capability of FAST in detecting such outflows.Comment: Accepted by ApJ

Is the mechanism of synchronous cardiocerebral infarction (CCI) different from that of metachronous CCI?

Background Cardiocerebral infarction (CCI) is the simultaneous occurrence of acute ischemic stroke (AIS) and myocardial infarction (MI) at the same time (synchronous), or one after another (metachronous). This study aimed to investigate the differences in the underlying mechanisms between synchronous and metachronous CCI. Methods This study analyzed patients with AIS registered in the Clinical Research Collaboration for Stroke in Korea Prospective Registry at a single Stroke Center from January 2019 to December 2022. Patients with synchronous and metachronous CCI (MI within 72 hours after AIS) were included. Severity at admission and modified Rankin Scale scores 3 months after treatment were assessed. Results Among 3,319 AIS patients, 12 (0.36%) were diagnosed with acute CCI (male, 8; mean age, 69.6±14.0 years). Of these, six (0.18%) had synchronous CCI, while the other six had metachronous CCI. The synchronous CCI group exhibited lower neurological severity at admission than the metachronous CCI group (median National Institutes of Health Stroke Scale, 3.5 vs. 12.5). Among the 12 patients, seven (58%) had ST-elevation myocardial infarction (STEMI), with five (83%) of the synchronous CCI cases presenting as STEMI. Two cases of new-onset atrial fibrillation occurred exclusively in patients with synchronous CCI. Also, one case with synchronous CCI had a thrombus in the left ventricle. Conclusion Acute CCI is rare and manifests with varying degrees of severity. Our study suggests that AIS in synchronous CCI may be secondary to embolism caused by a preceding MI. In contrast, metachronous CCI exhibits diverse mechanisms, including secondary myocardial injury resulting from a preceding severe AIS

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo

Nutrient deprivation strategies have been proposed as an adjuvant therapy for cancer cells due to their increased metabolic demand. We examined the specific inhibitory effects of amino acid deprivation on the metastatic phenotypes of the human triple-negative breast cancer (TNBC) cell lines MDA-MB-231 and Hs 578T, as well as the orthotopic 4T1 mouse TNBC tumor model. Among the 10 essential amino acids tested, methionine deprivation elicited the strongest inhibitory effects on the migration and invasion of these cancer cells. Methionine deprivation reduced the phosphorylation of focal adhesion kinase, as well as the activity and mRNA expression of matrix metalloproteinases MMP-2 and MMP-9, two major markers of metastasis, while increasing the mRNA expression of tissue inhibitor of metalloproteinase 1 in MDA-MB-231 cells. Furthermore, methionine restriction downregulated the metastasis-related factor urokinase plasminogen activatior and upregulated plasminogen activator inhibitor 1 mRNA expression. Animals on the methionine-deprived diet showed lower lung metastasis rates compared to mice on the control diet. Taken together, these results suggest that methionine restriction could provide a potential nutritional strategy for more effective cancer therapy