Ascomycotin A, a new citromycetin analogue produced by <i>Ascomycota</i> sp. Ind19F07 isolated from deep sea sediment

<div><p>A new citromycetin analogue, ascomycotin A (<b>1</b>), together with eight known compounds, wortmannilactone E (<b>2</b>), orcinol (<b>3</b>), orsellinic acid (<b>4</b>), isosclerone (<b>5</b>), (3<i>R</i>,4<i>S</i>)-( − )-4-hydroxymellein (<b>6</b>), diorcinol (<b>7</b>), chaetocyclinone B (<b>8</b>) and 2,5-dimethoxy-3,6-di(<i>p</i>-methoxypheny1)-1,4-benzoquinone (<b>9</b>), was isolated from the fungal strain <i>Ascomycota</i> sp. Ind19F07, which was isolated from the deep sea sediment of the Indian Ocean. The structures of the compounds were established by spectroscopic data including 1D and 2D NMR and HR-ESI-MS. Compounds (<b>1</b>–<b>9</b>) were evaluated for antibacterial activity.</p></div

New phenyl derivatives from endophytic fungus <i>Botryosphaeria</i> sp. SCSIO KcF6 derived of mangrove plant <i>Kandelia candel</i>

<div><p>Two new phenyl derivatives (<b>1</b> and <b>3</b>), along with two new natural products (<b>4</b> and <b>5</b>), and three known compounds (<b>2</b>, <b>6</b> and <b>7</b>), were isolated from an endophytic fungus <i>Botryosphaeria</i> sp. SCSIO KcF6. The structures of these compounds <b>1</b>–<b>7</b> were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds <b>1</b> and <b>3</b> were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound <b>3</b> exhibited a specific COX-2 inhibitory activity with the IC₅₀ value of 1.12 μM.</p></div