<div><p>Two new phenyl derivatives (<b>1</b> and <b>3</b>), along with two new natural products (<b>4</b> and <b>5</b>), and three known compounds (<b>2</b>, <b>6</b> and <b>7</b>), were isolated from an endophytic fungus <i>Botryosphaeria</i> sp. SCSIO KcF6. The structures of these compounds <b>1</b>–<b>7</b> were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds <b>1</b> and <b>3</b> were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound <b>3</b> exhibited a specific COX-2 inhibitory activity with the IC<sub>50</sub> value of 1.12 μM.</p></div
