262 research outputs found

    Managing Learning and Turnover in Employee Staffing

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    We study the employee staffing problem in a service organization that uses employee service capacities to meet random, non-stationary service requirements. The employees experience learning and turnover on the job, and we develop a Markov Decision Process (MDP) model that explicitly represents the stochastic nature of these effects. Theoretical results are developed that show the optimal hiring policy is of a state-dependent "hire-up-to" type, similar to the inventory "order-up-to" policy. This holds for discounted-costs MDP's under both finite and infinite planning horizons. We also develop structural properties of the optimal policy to facilitate computation of the optimal hiring numbers. For two important special cases of the general model, we prove the optimality of a myopic policy under both stationary and stochastically increasing service requirements. Moreover, we show that in these two cases, when service requirements are k-periodic, it is sufficient to solve a k-period MDP problem with appropriate end-of-horizon cost function. When general, non-stationary service requirements are present, we prove the existence of a one-sided "smoothing effect" of the optimal hire-up-to-levels. Numerical results show that the use of state-dependent hire-up-to policies may offer significant cost savings over simpler hiring policies. In particular, our results show that when employee capacity increase due to learning is substantial and flexible incremental capacity (overtime) is tight, a fully state-dependent policy out-performs a policy that hires only on the basis of the total number of employees in the system. Our problem formulation and results suggest natural connections to the classic results in inventory literature. We also discuss many of the connections and distinctions in the paper.

    A Single-Server Queue with Markov Modulated Service Times

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    We study an M/MMPP/1 queuing system, where the arrival process is Poisson and service requirements are Markov modulated. When the Markov Chain modulating service times has two states, we show that the distribution of the number-in-system is a superposition of two matrix-geometric series and provide a simple algorithm for computing the rate and coefficient matrices. These results hold for both finite and infinite waiting space systems and extend results obtained in Neuts [5] and Naoumov [4]. Numerical comparisons between the performance of the M/MMPP/1 system and its M/G/1 analogue lead us to make the conjecture that the M/MMPP/1 system performs better if and only if the total switching probabilities between the two states satisfy a simple condition. We give an intuitive argument to support this conjecture.

    Managing Learning and Turnover in Employee Staffing

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    We study the employee staffing problem in a service organization that uses employee service capacity to meet random, nonstationary service requirements. The employees experience learning and turnover on the job, and we develop a Markov Decision Process (MDP) model which explicitly represents the stochastic nature of these effects. Theoretical results show that the optimal hiring policy is of a state-dependent “hire-up-to” type, similar to an inventory “order-up-to” policy. For two important special cases, a myopic policy is optimal. We also test a linear programming (LP) based heuristic, which uses average learning and turnover behavior, in stationary environments. In most cases, the LP-based policy performs quite well, within 1% of optimality. When flexible capacity—in the form of overtime or outsourcing—is expensive or not available, however, explicit modeling of stochastic learning and turnover effects may improve performance significantly

    Call-Routing Schemes for Call-Center Outsourcing

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    Companies may choose to outsource parts, but not all, of their call-center operations. In the course of studying contact centers in the telecommunications and financial services industries, we have observed the following (apparently) common scheme. A company classifies its customers as high- or low-value, serving the former with their “in house” operations and routing the latter to an outsourcer. Typically, the company imposes service-level constraints on the time each type of customer waits on hold. This paper considers four schemes for routing low-value calls between the client company and the outsourcer. These schemes vary in the complexity of their routing algorithms, as well as the sophistication of the telephone and information technology infrastructure they require of the two operations. For three of these schemes, we provide a direct characterization of system performance. For the fourth, most complex, scheme we provide performance bounds for the important special case in which the service requirements of high- and low-value callers are the same. These results allow us to systematically compare the performance of the various routing schemes. Our results suggest that, for clients with large outsourcing requirements, the simpler schemes that require little client-outsourcer coordination can perform very well

    Managing Response Time in a Call-Routing Problem with Service Failure

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    Photosynthetic Bacterium \u3cem\u3eRhodopseudomonas palustris\u3c/em\u3e GJ-22 Induces Systemic Resistance Against Viruses

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    Photosynthetic bacteria (PSB) have been extensively used in agriculture to promote plant growth and to improve crop quality. Their potential application in plant disease management, however, is largely overlooked. In this study, the PSB strain Rhodopseudomonas palustris GJ-22 was investigated for its ability to induce resistance against a plant virus while promoting plant growth. In the field, a foliar spray of GJ-22 suspension protected tobacco plants against tobacco mosaic virus (TMV). Under axenic conditions, GJ-22 colonized the plant phyllosphere and induced resistance against TMV. Additionally, GJ-22 produced two phytohormones, indole-3-acetic acid and 5-aminolevulinic acid, which promote growth and germination in tobacco. Furthermore, GJ-22-inoculated plants elevated their immune response under subsequent TMV infection. This research may give rise to a novel biological agent with a dual function in disease management while promoting plant growth

    Isolation of Rhp-PSP, a Member of YER057c/YjgF/UK114 Protein Family with Antiviral Properties, from the Photosynthetic Bacterium \u3cem\u3eRhodopseudomonas palustris\u3c/em\u3e Strain JSC-3b

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    Rhodopseudomonas palustris strain JSC-3b isolated from a water canal adjacent to a vegetable field produces a protein that was purified by bioactivity-guided fractionation based on ammonium sulfate precipitation, ion-exchange absorption and size exclusion. The protein was further identified as an endoribonuclease L-PSP (Liver-Perchloric acid-soluble protein) by shotgun mass spectrometry analysis and gene identification, and it is member of YER057c/YjgF/UK114 protein family. Herein, this protein is designated Rhp-PSP. Rhp-PSP exhibited significant inhibitory activities against tobacco mosaic virus (TMV) in vivo and in vitro. To our knowledge, this represents the first report on the antiviral activity of a protein of the YER057c/YjgF/UK114 family and also the first antiviral protein isolated from R. palustris. Our research provides insight into the potential of photosynthetic bacterial resources in biological control of plant virus diseases and sustainable agriculture

    The LAMOST Complete Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap I. The Spectroscopic Redshift Catalog

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    We present a spectroscopic redshift catalog from the LAMOST Complete Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap (SGC), which is designed to observe all sources (Galactic and extra-galactic) by using repeating observations with a limiting magnitude of r=18.1 magr=18.1~mag in two 20 deg220~deg^2 fields. The project is mainly focusing on the completeness of LAMOST ExtraGAlactic Surveys (LEGAS) in the SGC, the deficiencies of source selection methods and the basic performance parameters of LAMOST telescope. In both fields, more than 95% of galaxies have been observed. A post-processing has been applied to LAMOST 1D spectrum to remove the majority of remaining sky background residuals. More than 10,000 spectra have been visually inspected to measure the redshift by using combinations of different emission/absorption features with uncertainty of σz/(1+z)<0.001\sigma_{z}/(1+z)<0.001. In total, there are 1528 redshifts (623 absorption and 905 emission line galaxies) in Field A and 1570 redshifts (569 absorption and 1001 emission line galaxies) in Field B have been measured. The results show that it is possible to derive redshift from low SNR galaxies with our post-processing and visual inspection. Our analysis also indicates that up to 1/4 of the input targets for a typical extra-galactic spectroscopic survey might be unreliable. The multi-wavelength data analysis shows that the majority of mid-infrared-detected absorption (91.3%) and emission line galaxies (93.3%) can be well separated by an empirical criterion of W2W3=2.4W2-W3=2.4. Meanwhile, a fainter sequence paralleled to the main population of galaxies has been witnessed both in MrM_r/W2W3W2-W3 and MM_*/W2W3W2-W3 diagrams, which could be the population of luminous dwarf galaxies but contaminated by the edge-on/highly inclined galaxies (30%\sim30\%).Comment: 19 pages, 14 figures, 2 MRT, accepted by ApJ

    Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models

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    Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, which is characterized by chronic bronchitis, destruction of small airways, and enlargement/disorganization of alveoli. It is generally accepted that the neutrophilic airway inflammation observed in the lungs of COPD patients is intrinsically linked to the tissue destruction and alveolar airspace enlargement, leading to disease progression. Animal models play an important role in studying the underlying mechanisms of COPD as they address questions involving integrated whole body responses. This review aims to summarize the current animal models of COPD, focusing on their advantages and disadvantages on immune responses and neutrophilic inflammation. Also, we propose a potential new animal model of COPD, which may mimic the most characteristics of human COPD pathogenesis, including persistent moderate-to-high levels of neutrophilic inflammation
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