Theory of Josephson current on a lattice model of grain boundary in dd-wave superconductors

Identifying the origins of suppression of the critical current at grain boundaries of high-critical-temperature superconductors, such as cuprates and iron-based superconductors, is a crucial issue to be solved for future applications with polycrystalline materials. Although the dominant factor of current suppression might arise during material fabrication and/or processing, investigating it due to an internal phase change of the pair potential is an important issue in understanding the threshold of the critical current. In this paper, we study the Josephson current on a symmetric [001]-tilt grain boundary (GB) of a $d$-wave superconductor on a lattice model. In addition to the suppression of the maximum Josephson current associated with the internal phase change of the $d$-wave pair potential which has been predicted in continuum models, we find a unique phase interference effect due to folding of the Fermi surface in the lattice model. In particular, the resultant maximum Josephson current at low-tilting-angle regions tends to be suppressed more than that in preexisting theories. Because similar suppressions of the critical current at GBs have been reported in several experimental works, the present model can serve as a guide to clarify the complicated transport mechanism in GBs

Aspergillus oryzae MIBA316糖質分解酵素の精製と性質

Amylolytic enzyme was purified to electrophoretically homogeneous state from culture broth of Aspergillus oryzae MIBA316. This enzyme hydrolyzed preferentially amylopectin, starch and glycogen. Approaches to complete breakdown of starch to its components and their utilization in food processing were discussed

ヒト爪および唾液細胞内アルデヒド脱水素酵素遺伝子の同定

An individual genotype of aldehyde dehydrogenase 2 (ALDH2) was surveyed and detected when using nail clippings and saliva, respectively by the method consisting of DNA extraction, genomic DNA amplification by polymerase chain reaction, and gel electrophoresis of DNA fragment. Gene analysis using fingernail DNA was found to be effective in that they were easily to collect from human samples, in that they were kept storable at -80℃ until use, and in that DNA of the sample was very stable after repeated treatment of freezing and thawing

QTL/microarray approach using pathway information

<p>Abstract</p> <p>Background</p> <p>A combined quantitative trait loci (QTL) and microarray-based approach is commonly used to find differentially expressed genes which are then identified based on the known function of a gene in the biological process governing the trait of interest. However, a low cutoff value in individual gene analyses may result in many genes with moderate but meaningful changes in expression being missed.</p> <p>Results</p> <p>We modified a gene set analysis to identify intersection sets with significantly affected expression for which the changes in the individual gene sets are less significant. The gene expression profiles in liver tissues of four strains of mice from publicly available microarray sources were analyzed to detect trait-associated pathways using information on the QTL regions of blood concentrations of high density lipoproteins (HDL) cholesterol and insulin-like growth factor 1 (IGF-1). Several metabolic pathways related to HDL levels, including lipid metabolism, ABC transporters and cytochrome P450 pathways were detected for HDL QTL regions. Most of the pathways identified for the IGF-1 phenotype were signal transduction pathways associated with biological processes for IGF-1's regulation.</p> <p>Conclusion</p> <p>We have developed a method of identifying pathways associated with a quantitative trait using information on QTL. Our approach provides insights into genotype-phenotype relations at the level of biological pathways which may help to elucidate the genetic architecture underlying variation in phenotypic traits.</p

Novel 3-dimensional virtual hepatectomy simulation combined with real-time deformation

AIM: To develop a novel 3-dimensional (3D) virtual hepatectomy simulation software, Liversim, to visualize the real-time deformation of the liver.METHODS: We developed a novel real-time virtual hepatectomy simulation software program called Liversim. The software provides 4 basic functions: viewing 3D models from arbitrary directions, changing the colors and opacities of the models, deforming the models based on user interaction, and incising the liver parenchyma and intrahepatic vessels based on user operations. From April 2010 through 2013, 99 patients underwent virtual hepatectomies that used the conventional software program SYNAPSE VINCENT preoperatively. Between April 2012 and October 2013, 11 patients received virtual hepatectomies using the novel software program Liversim; these hepatectomies were performed both preoperatively and at the same that the actual hepatectomy was performed in an operating room. The perioperative outcomes were analyzed between the patients for whom SYNAPSE VINCENT was used and those for whom Liversim was used. Furthermore, medical students and surgical residents were asked to complete questionnaires regarding the new software.RESULTS: There were no obvious discrepancies (i.e., the emergence of branches in the portal vein or hepatic vein or the depth and direction of the resection line) between our simulation and the actual surgery during the resection process. The median operating time was 304 min (range, 110 to 846) in the VINCENT group and 397 min (range, 232 to 497) in the Liversim group (P = 0.30). The median amount of intraoperative bleeding was 510 mL (range, 18 to 5120) in the VINCENT group and 470 mL (range, 130 to 1600) in the Liversim group (P = 0.44). The median postoperative stay was 12 d (range, 6 to 100) in the VINCENT group and 13 d (range, 9 to 21) in the Liversim group (P = 0.36). There were no significant differences in the preoperative outcomes between the two groups. Liversim was not found to be clinically inferior to SYNAPSE VINCENT. Both students and surgical residents reported that the Liversim image was almost the same as the actual hepatectomy.CONCLUSION: Virtual hepatectomy with real-time deformation of the liver using Liversim is useful for the safe performance of hepatectomies and for surgical education