Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-γ by flavonoids in mouse macrophages

AbstractPeroxisome proliferator-activated receptor (PPAR)γ transcription factor has been implicated in anti-inflammatory response. Of the compounds tested, apigenin, chrysin, and kaempferol significantly stimulated PPARγ transcriptional activity in a transient reporter assay. In addition, these three flavonoids strongly enhanced the inhibition of inducible cyclooxygenase and inducible nitric oxide synthase promoter activities in lipopolysaccharide-activated macrophages which contain the PPARγ expression plasmids. However, these three flavonoids exhibited weak PPARγ agonist activities in an in vitro competitive binding assay. Limited protease digestion of PPARγ suggested these three flavonoids produced a conformational change in PPARγ and the conformation differs in the receptor bound to BRL49653 versus these three flavonoids. These results suggested that these three flavonoids might act as allosteric effectors and were able to bind to PPARγ and activate it, but its binding site might be different from the natural ligand BRL49653

On the Successful Encapsulation of Water Droplets into Oil Droplets

Compound water-in-oil microdroplets can serve as microreactors in chemical and biological analyses. The inkjet printing is a useful technique to generate compound microdroplets by droplet impact. To understand the underlying physics during the droplet impact, a combined experimental and numerical study is carried out. The effect of spreading condition, impact velocity, and oil viscosity are investigated. The balance of the tripe-line among the three interfaces dominates primarily the stable morphology of the compound droplet. Reducing oil viscosity can reduce the required impact velocity. High impact velocity is necessary to reduce the side-slipping of the water droplet

Optical and HI properties of isolated galaxies in the 2MIG catalog. I. General relationships

We analyze empirical relationships between the optical, near infrared, and HI characteristics of isolated galaxies from the 2MIG Catalog covering the entire sky. Data on morphological types, K_S-, and B-magnitudes, linear diameters, HI masses, and rotational velocities are examined. The regression parameters, dispersions, and correlation coefficients are calculated for pairs of these characteristics. The resulting relationships can be used to test the hierarchical theory of galaxy formation through numerous mergers of cold dark matter.Comment: 18 pages, 11 figures, 5 table

Intakes of major food groups in China and UK: results from 100,000 adults in the China Kadoorie biobank and UK biobank

PURPOSE: Different populations may exhibit differences in dietary intakes, which may result in heterogeneities in diet-disease associations. We compared intakes of major food groups overall, by sex, and by socio-economic status (SES) (defined as both education and income), between participants in the China Kadoorie Biobank (CKB) and the UK Biobank (UKB). METHODS: Data were from ~ 25,000 CKB participants who completed a validated interviewer-administered computer-based questionnaire (2013-2014) and ~ 74,000 UKB participants who completed ≥ 3 web-based 24-h dietary assessments (2009-2012). Intakes of 12 major food groups and five beverages were harmonized and compared between the cohorts overall, by sex and by SES. Multivariable-adjusted linear regression examined the associations between dietary intakes and body mass index (BMI) in each cohort. RESULTS: CKB participants reported consuming more rice, eggs, vegetables, soya products, and less wheat, other staple foods (other than rice and wheat), fish, poultry, all dairy products, fruit, and beverages compared to UKB participants. Red meat intake was similar in both cohorts. Having a higher SES was generally associated with a higher consumption of foods and beverages in CKB, whereas in UKB dietary intakes differed more by education and income, with a positive association observed for meat and income in both UKB and CKB but an inverse association observed for education in UKB. Associations of dietary intakes with BMI varied between the two cohorts. CONCLUSION: The large differences in dietary intakes and their associations with SES and BMI could provide insight into the interpretation of potentially different diet-disease associations between CKB and UKB

Approximate techniques for dispersive shock waves in nonlinear media

Many optical and other nonlinear media are governed by dispersive, or diffractive, wave equations, for which initial jump discontinuities are resolved into a dispersive shock wave. The dispersive shock wave smooths the initial discontinuity and is a modulated wavetrain consisting of solitary waves at its leading edge and linear waves at its trailing edge. For integrable equations the dispersive shock wave solution can be found using Whitham modulation theory. For nonlinear wave equations which are hyperbolic outside the dispersive shock region, the amplitudes of the solitary waves at the leading edge and the linear waves at the trailing edge of the dispersive shock can be determined. In this paper an approximate method is presented for calculating the amplitude of the lead solitary waves of a dispersive shock for general nonlinear wave equations, even if these equations are not hyperbolic in the dispersionless limit. The approximate method is validated using known dispersive shock solutions and then applied to calculate approximate dispersive shock solutions for equations governing nonlinear optical media, such as nematic liquid crystals, thermal glasses and colloids. These approximate solutions are compared with numerical results and excellent comparisons are obtained

Relationship Between Soil Properties and Plant Diversity in a Desert Riparian Forest in the Lower Reaches of the Tarim River, Xinjiang, China

Based on data from soil characteristics of 217 soil samples collected from 31 soil profiles that were located at eight monitoring sections in the lower reaches of the Tarim River in southern Xinjiang, we analyzed the spatial distribution of soil properties using nonparametric tests and ANOVA. Plant species diversity was analyzed based on vegetation data that were collected over several years. In addition, the study also examined the relationship between plant species diversity and soil parameters by using grey correlation analysis. The results show a significant difference (p < 0.05) in soil organic matter, total N, and total K between the top layer (0-50cm) and the deep layers (>50cm). Along the different monitoring sections, going from the upper to the lower reaches at locations of 150m away from the right riverbank of the Tarim River, the plant species diversity index (Shannon-Weiner index) has the same trend as total N. Furthermore, plant communities change from compound communities to a single community corresponding to the changes in plant species diversity-namely, from the communities composed of trees (Populus euphratica Oliv.), shrubs (Tamarix spp), and herbs to a pure Tamarix community. Grey correlation analyses indicated that significant relationships exist between plant species diversity, soil organic matter, and total N at the 0-50cm soil layer

Agents of May Fourth. Jing Yinyu, Xu Zhongnian, and the Early Introduction of Modern Chinese Literature in France

Jing Yinyu (1901-1931?) and Xu Zhongnian (1904-1981) played a pivotal role in the dissemination of modern Chinese literature in France at the turn of the 1930s. Best known as Lu Xun’s first translator into a Western language and a friend of Romain Rolland’s, Jing compiled the Anthologie des conteurs chinois modernes in 1929. In his Anthologie de la littérature chinoise. Des origines à nos jours, published in 1932, Xu also devoted a section to recent literary developments. By analyzing the nature of the two projects, the translated corpora, and their paratexts, I will describe the features of Jing’s and Xu’s dissemination of May Fourth literature in France and scrutinize their artistic and ideological stance vis-à-vis the new literary scene. Ultimately, I will attempt to pinpoint in what terms the two scholars-cum-translators’ agency contributed to foreign readers’ awareness of the cultural, social and political experience of the May Fourth Movement

人乳头瘤病毒衣壳蛋白C末端结构臂具有免疫原性并参与病毒—宿主细胞的相互作用

文章简介宫颈癌是全球女性第二大常见恶性肿瘤,人乳头瘤病毒(HPV)是导致女性宫颈癌发生的主要原因。HPV型别众多,主要的高危型型别种类多达15种,且型别间免疫血清交叉保护能力极低,目前国际上已上市的预防性多价HPV疫苗均不能为接种者提供完全保护。长期以来,高分辨率HPV的病毒结构信息的缺乏限制了对HPV病毒的组装模式和感染机制的深入理解,进国家自然科学基金；美国国立卫生院(NIH)基金的资助

Delocalized single-photon Dicke states and the Leggett- Garg inequality in solid state systems

We show how to realize a single-photon Dicke state in a large one-dimensional array of two- level systems, and discuss how to test its quantum properties. Realization of single-photon Dicke states relies on the cooperative nature of the interaction between a field reservoir and an array of two-level-emitters. The resulting dynamics of the delocalized state can display Rabi-like oscillations when the number of two-level emitters exceeds several hundred. In this case the large array of emitters is essentially behaving like a mirror-less cavity. We outline how this might be realized using a multiple-quantum-well structure and discuss how the quantum nature of these oscillations could be tested with the Leggett-Garg inequality and its extensions.Comment: 29 pages, 5 figures, journal pape

ULK1/2所构成的信号节点除控制细胞自噬外还控制葡萄糖代谢通路

文章简介在细胞感受到环境中营养物质和生长因子的提供量发生改变后,代谢通路的重编程对于维持此时胞内的稳态是非常重要的过程。ULK1和ULK2是传递外界应激信号至自噬发生的重要整合因子。本项研究发现,在缺少氨基酸和生长因子时,ULK1/2能直接磷酸化多个糖酵解相关的酶,包括己糖激酶(HK)、国家自然科学基金重点项目；国家科技部(973课题)；国家基础科学人才培养基金等的经费支持