CD-CNN: A Partially Supervised Cross-Domain Deep Learning Model for Urban Resident Recognition

Driven by the wave of urbanization in recent decades, the research topic about migrant behavior analysis draws great attention from both academia and the government. Nevertheless, subject to the cost of data collection and the lack of modeling methods, most of existing studies use only questionnaire surveys with sparse samples and non-individual level statistical data to achieve coarse-grained studies of migrant behaviors. In this paper, a partially supervised cross-domain deep learning model named CD-CNN is proposed for migrant/native recognition using mobile phone signaling data as behavioral features and questionnaire survey data as incomplete labels. Specifically, CD-CNN features in decomposing the mobile data into location domain and communication domain, and adopts a joint learning framework that combines two convolutional neural networks with a feature balancing scheme. Moreover, CD-CNN employs a three-step algorithm for training, in which the co-training step is of great value to partially supervised cross-domain learning. Comparative experiments on the city Wuxi demonstrate the high predictive power of CD-CNN. Two interesting applications further highlight the ability of CD-CNN for in-depth migrant behavioral analysis.Comment: 8 pages, 5 figures, conferenc

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients with β-Thalassemia Major: A Meta-Analysis

Background. Endocrinopathies are common in patients with β-thalassemia major despite parenteral iron chelation therapy with deferoxamine. Prevalence of abnormal glucose metabolism in previous studies was controversial. The aim of this study was to discuss the prevalence of abnormal glucose metabolism in β-thalassemia major based on a meta-analysis. Methods. PubMed, ScienceDirect, Springerlink, Ovid, Web of Science, MEDLINE, Wanfang database, and Chinese National Knowledge Internet were searched for relevant articles. Two authors selected the articles according to the inclusion criteria and then extracted the data. The prevalence of diabetes mellitus (DM) in β-thalassemia major was defined as the primary outcome. The prevalence with the 95% confidence interval (95%CI) was used to evaluate the proportion of abnormal glucose metabolism and other endocrine disorders in patients with β-thalassemia major. Subgroup analyses were applied to explore the prevalence in different regions. Sensitivity analysis and publication bias assessment were also conducted. Results. A total of 44 studies with 16605 cases were included in this analysis. Diabetes mellitus was present in 6.54% (95% CI: 5.30%-7.78%). The fixed subgroup study revealed that the region with the highest prevalence was the Middle East (prevalence= 7.90%, 95% CI: 5.75%-10.05%). The accumulated meta-analysis revealed that the prevalence of DM in β-thalassemia major was relatively steady in each year. The prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and other endocrine disorders in β-thalassemia major was 17.21% (95% CI: 8.43%-26.00%), 12.46% (95% CI: 5.98%-18.94%), and 43.92% (95% CI: 37.94%-49.89%), respectively. Sensitivity analysis showed that the pooled results were robust; publication bias assessment revealed that there was no significant evidence that the pooled results were influenced by publication bias. Conclusion. High prevalence of endocrine disorders involving abnormal glucose metabolism was detected in β-thalassemia major. Treatment and prevention measurements may be necessary to prevent growth and endocrine problems

Design and chemical synthesis of eukaryotic chromosomes

We reviewed the design, building, testing and debugging technologies and methodologies for synthesizing designer eukaryotic chromosomes and forecasted their applications.</p