Azimuthal diffusion of the large-scale-circulation plane, and absence of significant non-Boussinesq effects, in turbulent convection near the ultimate-state transition

We present measurements of the orientation $\theta_0$ and temperature amplitude $\delta$ of the large-scale circulation in a cylindrical sample of turbulent Rayleigh-Benard convection (RBC) with aspect ratio $\Gamma \equiv D/L = 1.00$ ($D$ and $L$ are the diameter and height respectively) and for the Prandtl number $Pr \simeq 0.8$. Results for $\theta_0$ revealed a preferred orientation with upflow in the West, consistent with a broken azimuthal invariance due to Earth's Coriolis force [see \cite{BA06b}]. They yielded the azimuthal diffusivity $D_\theta$ and a corresponding Reynolds number $Re_{\theta}$ for Rayleigh numbers over the range $2\times 10^{12} < Ra < 1.5\times 10^{14}$. In the classical state ($Ra < 2\times 10^{13}$) the results were consistent with the measurements by \cite{BA06a} for $Ra < 10^{11}$ and $Pr = 4.38$ which gave $Re_{\theta} \propto Ra^{0.28}$, and with the Prandtl-number dependence $Re_{\theta} \propto Pr^{-1.2}$ as found previously also for the velocity-fluctuation Reynolds number $Re_V$ \cite[]{HGBA15b}. At larger $Ra$ the data for $Re_{\theta}(Ra)$ revealed a transition to a new state, known as the "ultimate" state, which was first seen in the Nusselt number $Nu(Ra)$ and in $Re_V(Ra)$ at $Ra^*_1 \simeq 2\times 10^{13}$ and $Ra^*_2 \simeq 8\times 10^{13}$. In the ultimate state we found $Re_{\theta} \propto Ra^{0.40\pm 0.03}$. Recently \cite{SU15} claimed that non-Oberbeck-Boussinesq effects on the Nusselt and Reynolds numbers of turbulent RBC may have been interpreted erroneously as a transition to a new state. We demonstrate that their reasoning is incorrect and that the transition observed in the G\"ottingen experiments and discussed in the present paper is indeed to a new state of RBC referred to as "ultimate".Comment: 12 pages, 4 figures, to be pub. in JFM

Logarithmic temperature profiles of turbulent Rayleigh-B\'enard convection in the classical and ultimate state for a Prandtl number of 0.8

We report on experimental determinations of the temperature field in the interior (bulk) of turbulent Rayleigh-Benard convection for a cylindrical sample with aspect ratio (diameter over height) of 0.50, both in the classical and in the ultimate state. The Prandtl number was close to 0.8. We find a "logarithmic layer" in which the temperature varies as A*ln(z/L) + B with the distance z from the bottom plate of the sample. The amplitude A varies with radial position r. In the classical state these results are in good agreement with direct numerical simulations (DNS); in the ultimate state there are as yet no DNS. A close analogy between the temperature field in the classical state and the "Law of the Wall" for the time-averaged down-stream velocity in shear flow is discussed.Comment: 27 pages, 15 figure

Mean velocity and temperature profiles in turbulent Rayleigh-Bénard convection at low Prandtl numbers

We report a direct numerical simulation (DNS) study of the mean velocity and temperature profiles in turbulent Rayleigh-Bénard convection (RBC) at low Prandtl numbers (Pr). The numerical study is conducted in a vertical thin disk with Pr varied in the range 0.17 ≤ Pr ≤ 4.4 and the Rayleigh number (Ra) varied in the range 5 × 10^8 ≤ Ra ≤ 1 × 10^10. By varying Pr from 4.4 to 0.17, we find a sharp change of flow patterns for the large-scale circulation (LSC) from a rigid-body rotation to a near-wall turbulent jet. We numerically examine the mean velocity equation in the bulk region and find that the mean horizontal velocity profile u(z) can be determined by a balance equation between the mean convection and turbulent diffusion with a constant turbulent viscosity νt. This balance equation admits a self-similarity jet solution, which fits the DNS data well. In the boundary-layer region, we find that both the mean temperature profile T(z) and u(z) can be determined by a balance equation between the molecular diffusion and turbulent diffusion. Within the viscous boundary layer, both u(z) and T(z) can be solved analytically and the analytical results agree well with the DNS data. Our careful characterisation of the mean velocity and temperature profiles in low-Pr RBC provides a further understanding of the intricate interplay between the LSC, plume emission and boundary-layer dynamics, and pinpoints the physical mechanism for the emergence of a pronounced LSC in low-Pr RBC

Heat transport by turbulent Rayleigh-B\'enard convection for $\Pra\ \simeq 0.8and and 3\times 10^{12} \alt \Ra\ \alt 10^{15}:Aspectratio: Aspect ratio \Gamma = 0.50$

We report experimental results for heat-transport measurements, in the form of the Nusselt number \Nu, by turbulent Rayleigh-B\'enard convection in a cylindrical sample of aspect ratio $\Gamma \equiv D/L = 0.50$ ($D = 1.12$ m is the diameter and $L = 2.24$ m the height). The measurements were made using sulfur hexafluoride at pressures up to 19 bars as the fluid. They are for the Rayleigh-number range 3\times 10^{12} \alt \Ra \alt 10^{15} and for Prandtl numbers \Pra\ between 0.79 and 0.86. For \Ra < \Ra^*_1 \simeq 1.4\times 10^{13} we find \Nu = N_0 \Ra^{\gamma_{eff}} with $\gamma_{eff} = 0.312 \pm 0.002$, consistent with classical turbulent Rayleigh-B\'enard convection in a system with laminar boundary layers below the top and above the bottom plate. For \Ra^*_1 < \Ra < \Ra^*_2 (with \Ra^*_2 \simeq 5\times 10^{14}) $\gamma_{eff}$ gradually increases up to $0.37\pm 0.01$. We argue that above \Ra^*_2 the system is in the ultimate state of convection where the boundary layers, both thermal and kinetic, are also turbulent. Several previous measurements for $\Gamma = 0.50$ are re-examined and compared with the present results.Comment: 44 pages, 18 figures, submitted to NJ

Current Perspectives on Role of MSC in Renal Pathophysiology

In the course of the development and worsening of kidney disease, the treatments available are expensive and may cause adverse effects such as immune rejection, inadequate renal resources, or post-operative complications. Therefore, there is an urgent to develop more effective treatments. The advent of mesenchymal stem cells (MSCs) represents a new direction in this context. The current use of MSCs for the treatment of kidney disease has mostly involved experimental studies on animals and only a few clinical trials have been conducted. This review focused on the mechanisms of MSC involvement from different sources in the improvement of renal pathophysiology in recent years. These mechanisms include homing to damaged kidney tissue, and differentiating into or fusing with the innate cells of the kidney. The paracrine or endocrine action through secreting protective cytokines and/or releasing microvesicle from MSCs also plays a critical role in amelioration of kidney disease. With modern engineering technology like microRNA delivery and a combinational therapy approach such as reduction of renal fibrosis in obstructive nephropathy with MSCs and serelaxin, MSC may make great contribution to the improvement of renal pathophysiology. However, the therapeutic effects of MSC are still controversial and several problems remain unsolved. While it is too early to state that MSCs are useful for the treatment of renal diseases in clinic, it is thought that solutions to the existing problems will enable effective modulation of the biological characteristics of MSCs, thereby providing new and effective approaches for the treatment of renal diseases

The Effects of Electrical Acupuncture and Essential Amino Acid Supplementation on Sarcopenic Obesity in Male Older Adults: A Randomized Control Study

Objective: Aging which is accompanied by loss of skeletal muscle and increase of body fat in some adults older than 60 years does not only result in remarkable influences on daily life function but also increases the risk of cardiovascular events. This study used electrical acupuncture together with essential amino acid supplementation to treat sarcopenic obesity (SO) in male older adults. Methods: A total of 48 male participants with SO (>60 years old) were randomized to electrical acupuncture with oral essential amino acids (EA + AA) or oral essential amino acids alone (AA). Acupuncture points on the limbs were punctured and stimulated electrically once every 3 days for 12 weeks. All participants received essential amino acids orally, twice per day for 28 weeks. Body fat percentage (BFP) and appendicular skeletal muscle index (ASM/H2) was determined by bioelectrical impedance analysis. Results: Both groups exhibited significant changes in BFP after 12, 20, and 28 weeks compared with baseline values; for ASM/H2, there were significant differences to baseline values after 12, 20, and 28 weeks in the EA + AA group, but only after 28 weeks in the AA group. Between the two groups, there were significant differences in BFP after 12, 20, and 28 weeks, and in ASM/H2 after 20 and 28 weeks. Conclusion: Both methods decrease BFP and increase ASM/H2. In male older adults, electrical acupuncture with oral essential amino acids is more effective and can increase muscle mass in a shorter time than oral essential amino acids alone

Vertical Federated Learning

Vertical Federated Learning (VFL) is a federated learning setting where multiple parties with different features about the same set of users jointly train machine learning models without exposing their raw data or model parameters. Motivated by the rapid growth in VFL research and real-world applications, we provide a comprehensive review of the concept and algorithms of VFL, as well as current advances and challenges in various aspects, including effectiveness, efficiency, and privacy. We provide an exhaustive categorization for VFL settings and privacy-preserving protocols and comprehensively analyze the privacy attacks and defense strategies for each protocol. In the end, we propose a unified framework, termed VFLow, which considers the VFL problem under communication, computation, privacy, and effectiveness constraints. Finally, we review the most recent advances in industrial applications, highlighting open challenges and future directions for VFL