Tomographic PIV measurement of coherent dissipation scale structures

Movie files referred to in Appendix D (p.213) not included in e-thesis.Further understanding the small scale coherent structures which occur in high Reynolds number turbulence would be of enormous benefit. Therefore, the aim of the current project was to make well resolved three-dimensional flow measurements of the mixing flow between counter rotating impellers, using Tomographic Particle Image Velocimetry (TPIV). TPIV software was developed, with a novel approach permitting a significant reduction in processing time, and a series of numerical accuracy studies contributing to the fundamental understanding of this new technique. Basic flow characterisation determined the local isotropy, homogeneity and expected Reynolds number scaling. A favourable comparison between planar PIV and TPIV increased confidence in the latter, which was used to assess the dynamics and topology of the dissipation scale structures. In support of previous investigations similar topology, strain rate alignment, scale-invariance, and clustering behaviours are demonstrated. Correlated high enstrophy and dissipation regions occur in the periphery of larger structures, resulting in intermittency. Geometry characterisation indicates a predominance of tube-like structures, which are observed to form from larger ribbon-like structures through unsteady breakdown and vortex roll-up. Significant correlation between intermittent fields of dissipation and enstrophy describe the fine scales effects. These relationships should pave the way for more accurate models, capable of relating small scales and large scales during the prediction of dynamically important quantities.The author wishes to acknowledge funding from the Engineering and Physical Sciences Research Council through Grant No. GR/S78667/01 and a Cambridge University Doctoral Training Award

Theoretical studies of compressed xenon oxides, tin selenide thermoelectrics, and defects in graphene

Enormous advances in computing power in recent decades have made it possible to perform accurate numerical simulations of a wide range of systems in condensed matter physics. At the forefront of this progress has been density functional theory (DFT), a very popular approach to tackling the complexity of quantum-mechanical systems that very often strikes a good balance between accuracy and tractability in light of the finite computational resources available to researchers. This thesis describes work utilising DFT methods to tackle two distinct problems. Firstly, the theoretical prediction of stable and metastable periodic structures under specified conditions using the ab initio random structure searching (AIRSS) method, which involves a large scale exploration of the Born-Oppenheimer energy surface, and secondly the use of a vibrational self-consistent field (VSCF) approach to investigate the effects of nuclear motion and anharmonicity in crystal systems, which involves a local exploration of the Born-Oppenheimer energy surface. The AIRSS crystal structure prediction method is here applied to a study of defect structures in graphene. It is also applied to a study of the xenon-oxygen binary system under a range of geological pressures (83–200 GPa). Novel xenon oxide structures are predicted and characterised theoretically. This work was carried out in collaboration with an experimental study of the system at the lower end of the pressure range. The VSCF approach to investigating anharmonicity is here applied to the study of tin selenide (SnSe), a material that has recently been shown to demonstrate consider- able promise as a thermoelectric material. In this thesis, the effects of the anharmonic nuclear motion on the vibrational and electronic properties of SnSe are investigated quantitatively.Engineering and Physical Sciences Research Council (EPSRC) studentshi

Statistical Analysis for Hospital Length-of-Stay and Readmission Rate Study

Hospital readmission rate has become a major indicator of quality of care, with penalties given to hospitals that have high rates of readmission. At the same time, insurers are applying increasing pressure to improve efficiency and reduce costs, including decreasing hospital lengths of stay. We analyze these trends to determine if reducing lengths of stay (LOS) may actually worsen readmission rates. All records of patients admitted to the neurosurgical service at one hospital from October 2007 through June 2014 were aggregated and analyzed for several variables, including initial length of stay, readmission occurrence, and length of stay, admitting diagnosis, admission priority and discharge disposition. Any trends over time were also noted. 925 out of 9,409 patient encounters are readmissions. Readmission rate and average length of stay were found significantly negative correlated. Besides linear regression which directly connecting average length of stay and readmission rate, survival analysis methods with Cox proportional hazard ratio model were employed to determine which factors were associated with a higher risk of readmission. There was a clear increase in readmissions over the study period, but LOS remained relatively constant, suggesting that increasing medical complexity confounded efforts to decrease LOS and was responsible for increased readmission rates. This study can help providers avoid readmissions by focusing on effective management of comorbidities

Hospital Length of Stay and Readmission Rate for Neurosurgical Patients

BACKGROUND Hospital readmission rate has become a major indicator of quality of care, with penalties given to hospitals with high rates of readmission. At the same time, insurers are increasing pressure for greater efficiency and reduced costs, including decreasing hospital lengths of stay (LOS). OBJECTIVE To analyze the authors’ service to determine if there is a relationship between LOS and readmission rates. METHODS Records of patients admitted to the authors’ institution from October 2007 through June 2014 were analyzed for several data points, including initial LOS, readmission occurrence, admitting and secondary diagnoses, and discharge disposition. RESULTS Out of 9409 patient encounters, there were 925 readmissions. Average LOS was 6 d. Univariate analysis indicated a higher readmission rate with more diagnoses upon admission (P < .001) and an association between insurance type and readmission (P < .001), as well as decreasing average yearly LOS (P = .0045). Multivariate analysis indicated statistically significant associations between longer LOS (P = .03) and government insurance (P < .01). CONCLUSION A decreasing LOS over time has been associated with an increasing readmission rate at the population level. However, at the individual level, a prolonged LOS was associated with a higher risk of readmission. This was attributed to patient comorbidities. However, this increasing readmission rate may represent many factors including patients’ overall health status. Thus, the rate of readmission may represent a burden of illness rather than a valid metric for quality of care

Numerical investigation of azimuthal thermoacoustic instability in a gas turbine model combustor

Self-excited spinning mode azimuthal instability in an annular combustor with non-swirling flow is investigated using large eddy simulation (LES). Compressible Navier-Stoke equations are solved with a flamelet combustion model to describe the subgrid chemistry$-$turbulence interactions. Two flamelet models, with and without heat loss effects, are compared to elucidate the non-adiabatic wall effects on the thermoacoustic instability. The azimuthal modes are captured well by both models with only marginal differences in the computed frequencies and amplitudes. By comparing with the experimental measurements, the frequencies given by the LES are approximately 10\% higher and the amplitudes are well predicted. Further analysis of the experimental and LES data shows a similar dominant anti-clockwise spinning mode, under which a good agreement is observed for the phase-averaged heat release rate fluctuations. Dynamic mode decomposition (DMD) is applied to shed more light on this spinning mode. The LES and experimental DMD modes reconstructed for their azimuthal mode frequencies agree very well for the heat release fluctuations. The DMD mode structure for the acoustic pressure from the LES shows a considerable non-zero profile at the combustor outlet, which could be essential for azimuthal modes to establish in this annular combustor. Finally, a low-order modelling study was conducted using an acoustic network combined with the flame transfer function extracted from LES. The results show that the dominant mode is associated with the plenum showing a first longitudinal and azimuthal mixed mode structure. By tuning the plenum length to match the effective volume, the predicted frequency becomes very close to the measured value

Killer Heat in the United States: Climate Choices and the Future of Dangerously Hot Days

This UCS analysis provides a detailed view of how extreme heat events caused by dangerous combinations of temperature and humidity are likely to become more frequent and widespread in the United States over this century. It also describes the implications for everyday life in different regions of the country.We have analyzed where and how often in the contiguous United States the heat index—also known as the National Weather Service (NWS) "feels like" temperature—is expected to top 90°F, 100°F, or 105°F during future warm seasons (April through October). While there is no one standard definition of "extreme heat," in this report we refer to any individual days with conditions that exceed these thresholds as extreme heat days. We also analyzed the spread and frequency of heat conditions so extreme that the NWS formula cannot accurately calculate a corresponding heat index. The "feels like" temperatures in these cases are literally off the charts.We have conducted this analysis for three global climate scenarios associated with different levels of global heattrapping emissions and future warming. These scenarios reflect different levels of action to reduce global emissions, from effectively no action to rapid action. Even the scenario of rapid action to reduce emissions does not spare our communities a future of substantially increased extreme heat. For the greatest odds of securing a safe climate future for ourselves and the ecosystems we all depend on, we would need to take even more aggressive action, in the US and globally, than outlined in any of the scenarios used here. Our challenge is great, but the threat of not meeting it is far greater

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants

To estimate risk of NEC for ELBW infants as a function of preterm formula and maternal milk (MM) intake and calculate the impact of suboptimal feeding on NEC incidence and costs

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility