Sanctuary on the Mississippi: St. Louis as a Way Station for Mormon Emigration

In the decades before the Civil War, St. Louis was considered by The Church of Jesus Christ of Latter-day Saints to be the most Mormon-friendly city outside Salt Lake City. Thomas Farmer and Fred Woods examine the ways Mormons used St. Louis as a way station to earn money and replenish resources, while at the same time contributing to its growth

A Study of Total and Reduced Glutathione with Oxygen Content and Capacity in the Blood of Pregnant and Non-Pregnant Women

Much speculation has been offered as to the exact nature and function of glutathione in circulating blood. It has often been considered as playing some part in cell respiration. A study has been made on total and reduced glutathione content of blood in the non-pregnant, in the pregnant during the labor and the parturition including cord blood, during the postpartum four-ten days, and in the toxemias of pregnancy. This offered an opportunity to study the relation between total and reduced glutathione in blood under conditions of varying oxygen content and capacity of systemic blood. The study also included a group of experiments in which blood (with and without fluorides) kept at -3°, 23°, and 38°C. for periods as long as seventy-two hours was analyzed at given intervals for total and reduced glutathione. Oxygen content of the blood was also determined simultaneously with glutathione on the specimen kept at 38°C

Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles

Background Whether racial/ethnic disparities in Alzheimer’s disease (AD) risk may be explained by ambient fine particles (PM2.5) has not been studied. Methods We conducted a prospective, population-based study on a cohort of Black (n=481) and White (n=6004) older women (aged 65-79) without dementia at enrollment (1995-98). Cox models accounting for competing risk were used to estimate the hazard ratio (HR) for racial/ethnic disparities in AD (1996-2010) defined by DSM-IV and the association with time-varying annual average PM2.5 (1999-2010) estimated by spatiotemporal model. Results Over an average follow-up of 8.3 (±3.5) years with 158 incident cases (21 in Black women), the racial disparities in AD risk (range of adjusted HRBlack women = 1.85-2.41) observed in various models could not be explained by geographic region, age, socioeconomic characteristics, lifestyle factors, cardiovascular risk factors, and hormone therapy assignment. Estimated PM2.5 exposure was higher in Black (14.38±2.21 µg/m 3) than in White (12.55±2.76 µg/m 3) women, and further adjustment for the association between PM2.5 and AD (adjusted HRPM2.5 = 1.18-1.28) slightly reduced the racial disparities by 2-6% (HRBlack women = 1.81-2.26). The observed association between PM2.5 and AD risk was ~2 times greater in Black (HRPM2.5 = 2.10-2.60) than in White (HRPM2.5 = 1.07-1.15) women (range of interaction Ps: Conclusions PM2.5 may contribute to racial/ethnic disparities in AD risk and its associated increase in AD risk was stronger amongst Black women

Lyman‐α imaging of the SO 2 distribution on Io

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94916/1/grl12620.pd

A novel pathogenic MLH1 missense mutation, c.112A > C, p.Asn38His, in six families with Lynch syndrome

<p>Abstract</p> <p>Background</p> <p>An unclassified variant (UV) in exon 1 of the <it>MLH1 </it>gene, c.112A > C, p.Asn38His, was found in six families who meet diagnostic criteria for Lynch syndrome. The pathogenicity of this variant was unknown. We aim to elucidate the pathogenicity of this <it>MLH1 </it>variant in order to counsel these families adequately and to enable predictive testing in healthy at-risk relatives.</p> <p>Methods</p> <p>We studied clinical data, microsatellite instability and immunohistochemical staining of MMR proteins, and performed genealogy, haplotype analysis and DNA testing of control samples.</p> <p>Results</p> <p>The UV showed co-segregation with the disease in all families. All investigated tumors showed a microsatellite instable pattern. Immunohistochemical data were variable among tested tumors. Three families had a common ancestor and all families originated from the same geographical area in The Netherlands. Haplotype analysis showed a common haplotype in all six families.</p> <p>Conclusions</p> <p>We conclude that the <it>MLH1 </it>variant is a pathogenic mutation and genealogy and haplotype analysis results strongly suggest that it is a Dutch founder mutation. Our findings imply that predictive testing can be offered to healthy family members. The immunohistochemical data of MMR protein expression show that interpreting these results in case of a missense mutation should be done with caution.</p